NCT04337983

Hemodynamic Characteristics of Patients With SARS-CoV-2

Hemodynamic Characteristics of Patients With SARS-CoV-2: PiCCOVID Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: Bicetre Hospital · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been declared a public health emergency of international concern. Hospitalized COVID-19-positive patients requiring ICU care is increasing along with the course of epidemic. A large number of these patients developed acute respiratory distress syndrome (ARDS) according to current data. However, the related hemodynamic characteristic has so far been rarely described.

Detailed description

The outbreak of COVID-19 is a worldwide concern. To our knowledge, the details of the hemodynamic characteristics of COVID-19 patients have not yet been well described. Besides, the cardiac injury was reported in about 7-17% of hospitalized patients with COVID-19 in previous Chinese publications and is much more common in patients admitted to ICU and non-survivors. However, no systematic assessment, including echocardiography evaluating the left ventricular function of these patients has been declared. In addition, extravascular lung water (EVLW) and pulmonary capillary permeability are two hall markers in ARDS patient's management, and transpulmonary thermodilution is a validated method to provide these values at the bedside. However, no study has reported the characteristic profile of these variables during ARDS caused by SARS-Cov2. A better knowledge of these characteristics would also be helpful in guiding their management.

Conditions

• Coronavirus
• SARS-CoV-2
• COVID-19
• Acute Respiratory Distress Syndrome
• Shock
• Acute Circulatory Failure
• Left Ventricular Dysfunction
• Fluid Overload

Interventions

Type	Name	Description
DEVICE	Transpulmonary thermodilution	Obtained by averaging the results of three thermodilution measurements. Each thermodilution is performed by injecting a bolus (15 mL) of cold saline (less than 10°C)
DEVICE	Echocardiography	Daily echocardiography evaluation

Timeline

• Start date: 2020-03-13
• Primary completion: 2020-10-30
• Completion: 2020-11-30
• First posted: 2020-04-08
• Last updated: 2021-09-14

Locations

1 site across 1 country: France