Trials / Completed
CompletedNCT04103996
Incidence, Risk Factors and Outcomes of Diaphragm Dysfunction After Lung Transplantation
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 15 (actual)
- Sponsor
- University Health Network, Toronto · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The study is designed to characterize the changes in diaphragm function after lung transplantation.
Detailed description
Diaphragm dysfunction (DD) is a well-known complication after lung transplantation. Patients with an injured and dysfunctional diaphragm have greater difficulty weaning from mechanical ventilation post-transplant - they become too weak to breathe. However, little is known about the pre-transplant predictive factors associated with diaphragm dysfunction . We have developed a new technique employing beside ultrasound to measure diaphragm thickness. This allows us to observe changes in diaphragm muscle structure and function. The goal of the study is to determine whether pre-transplant diaphragm thickness and function are associated with diaphragmatic dysfunction after lung transplantation. This will help us to confirm the best way to avoid diaphragm injury and to understanding the meaning of diaphragm ultrasound images.
Conditions
- Diaphragm Injury
- Lung Transplant; Complications, Mechanical
- Respiratory Failure
- Mechanical Ventilation Complication
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Ultrasound | Sonographic measurements (diaphragm, abdominal muscle, and quadriceps thickness) will be acquired when listed for lung transplantation. Sonographic measurements will be recorded on a daily basis for up to 1 week after transplantation (while the patient remains intubated). |
| DIAGNOSTIC_TEST | Respiratory function measurements | Maximal expiratory pressure (MEP) and maximal inspiratory pressure (MIP) will be acquired after listing for lung transplantation. After transplant, MIP will be recorded once patients are eligible for a trial of spontaneous breathing and weekly thereafter. MEP will also be recorded at ICU discharge. |
Timeline
- Start date
- 2020-02-10
- Primary completion
- 2021-12-31
- Completion
- 2021-12-31
- First posted
- 2019-09-26
- Last updated
- 2024-12-11
Locations
1 site across 1 country: Canada
Source: ClinicalTrials.gov record NCT04103996. Inclusion in this directory is not an endorsement.