NCT03768232

Ventilator Induced Diaphragm Dysfunction in Pediatric Critically Ill Patients (VIDD)

Ventilator Induced Diaphragm Dysfunction in Pediatric Critically Ill Patients

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 80 (estimated)
• Sponsor: Bambino Gesù Hospital and Research Institute · Academic / Other
• Sex: All
• Age: 28 Days – 18 Years
• Healthy volunteers: Not accepted

Summary

evaluation of diaphragmatic disfunction eventually occurred in pediatric patient undergoing mechanical ventilation therapy

Detailed description

Physician will perform US diaphragm measurements within 36 hours of initiation of MV. Measurements will be repeated daily for the duration of MV for the first week, then every 48 hours and 24 hours after the extubation. Exposure to and duration of continuous NMBA infusion during the course of MV and use of CS will be recorded. Ventilator logs and arterial gas analysis will be checked at the time of each US measurement to ascertain ventilator settings and SBF for the 24 hours preceding each US measurement. Extubation success will be defined as no requirement for reintubation within 48 hours following extubation. The use of NIV immediately after extubation will be decided by the physician in charge according to the patient clinical history (presence of withdrawal syndrome, ect) and NOT according to DTF measurement.

Conditions

• Respiratory Failure
• Respiratory Distress Syndrome
• Mechanical Ventilation Complication

Interventions

Type	Name	Description
OTHER	ultrasound asessment	US diaphragm measurements within 36 hours of initiation of MV. Measurements will be repeated daily for the duration of MV for the first week, then every 48 hours and 24 hours after the extubation.

Timeline

• Start date: 2019-01-01
• Primary completion: 2020-01-01
• Completion: 2020-01-01
• First posted: 2018-12-07
• Last updated: 2018-12-07