NCT02814591

Development of a Non-invasive Assessment of Human Bone Quality Using Spatially Offset Raman Spectroscopy

Development of a Novel, Safe Method for the Non-invasive Assessment of Human Bone Quality, In Vivo, Using Spatially Offset Raman Spectroscopy

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 245 (estimated)
• Sponsor: University College, London · Academic / Other
• Sex: All
• Age: 0 Years
• Healthy volunteers: Accepted

Summary

In this study spatially offset Raman spectroscopy (SORS), which allows the collection of Raman spectra through turbid media, is being applied to collect Raman spectra of bone. The principal aim to find ways to use Raman spectroscopy to assess bone quality in vivo.

Conditions

• Osteoarthritis
• Osteoporosis
• Osteogenesis Imperfecta
• Rickets / Osteomalacia
• Bone Infection

Interventions

Type	Name	Description
DEVICE	spatially offset Raman spectrometer (SORS)	Raman spectra will be collected non-invasively from patients using a lower power 830 nm laser. A probe is brought into gentle contact with the patients skin and measurements taken. The laser power has a pre-defined safe threshold of 30 mW into a 3.5 mm diameter aperture. Built in device safety features prevent this threshold from being exceeded. The probe that comes into patient contact is suitable for disinfecting.

Timeline

• Start date: 2011-10-01
• Primary completion: 2024-06-01
• Completion: 2025-06-01
• First posted: 2016-06-28
• Last updated: 2022-11-23