| Recruiting | Pediatric Safety Follow-up Study of Prior Treatment With Romosozumab for Osteogenesis Imperfecta NCT07366086 | Amgen | Phase 3 |
| Not Yet Recruiting | Mesenchymal Cell Therapy in Osteogenesis Imperfecta (OI) NCT05559801 | Emory University | Phase 1 / Phase 2 |
| Recruiting | REMS25: Study on the Use of REMS Technology in Diseases Commonly Associated With Reduced Bone Mineral Density NCT07412782 | Meyer Children's Hospital IRCCS | N/A |
| Not Yet Recruiting | Pediatric Arthropathy Beyond Inflammation: Clinical Spectrum and Diagnostic Approach at Assiut University Chil NCT07173010 | Assiut University | — |
| Recruiting | Prospective Observational Cohort Study of Cardiac Structure and Function in Children and Adults With Osteogene NCT07287241 | Istituto Ortopedico Rizzoli | — |
| Active Not Recruiting | Setrusumab in Pediatric Japanese Subjects With Osteogenesis Imperfecta NCT06636071 | Ultragenyx Pharmaceutical Inc | Phase 3 |
| Completed | Post-market Observational Study on JTIN Telescopic Nail in Osteogenesis Imperfecta Pediatric Patients NCT05612139 | Orthofix s.r.l. | — |
| Completed | Ready to Sail: Evaluating Sailing's Feasibility as Ergotherapy NCT06397443 | Istituto Ortopedico Rizzoli | N/A |
| Recruiting | Study to Evaluate Efficacy and Safety of Romosozumab Compared With Bisphosphonates in Children and Adolescents NCT05972551 | Amgen | Phase 3 |
| Recruiting | Adapted Physical Activity Program (APA) for Effort Rehabilitation of Children and Teenagers With Osteogenesis NCT05927389 | University Hospital, Toulouse | N/A |
| Not Yet Recruiting | Site Preservation After Tooth Extraction NCT05258019 | Nanfang Hospital, Southern Medical University | — |
| Completed | A First-in-Human Study Evaluating AGA2115 in Adult Healthy Volunteers NCT06086613 | Angitia Incorporated Limited | Phase 1 |
| Unknown | Study of Osteogenesis Imperfecta Tendon NCT06065111 | Université Catholique de Louvain | — |
| Unknown | Management of Combined Fracture Neck of Femur and Femoral Deformity in Osteogenesis Imperfecta Patient NCT05878548 | Assiut University | N/A |
| Active Not Recruiting | Setrusumab vs Bisphosphonates in Pediatric Subjects With Osteogenesis Imperfecta NCT05768854 | Ultragenyx Pharmaceutical Inc | Phase 3 |
| Unknown | Osteogenesis Imperfecta and Balance NCT06010134 | South Valley University | N/A |
| Active Not Recruiting | Increasing Knowledge on Osteogenesis Imperfecta by Collecting Epidemiological Data NCT06193642 | Istituto Ortopedico Rizzoli | N/A |
| Recruiting | Audio-vestibular Evaluation of Children and Young Adults With Osteogenesis Imperfecta NCT05419960 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | e-Health Care Method for Patients With Osteogenesis Imperfecta (Tele OI) NCT06555536 | Paulo Humberto Mem Martendal Vallandro Costa | N/A |
| Terminated | Single Ascending Dose Study of SAR439459 in Adults With Osteogenesis Imperfecta (OI) NCT05231668 | Sanofi | Phase 1 |
| Active Not Recruiting | Clear Aligners for the Treatment of Dental Malocclusion in OI NCT04815564 | Baylor College of Medicine | N/A |
| Active Not Recruiting | Cardiopulmonary Outcomes in Osteogenesis Imperfecta: BBD7708 NCT05317637 | Baylor College of Medicine | — |
| Completed | Tranexamic Acid During Telescoping Nail Application In Osteogenesis Imperfecta NCT05321199 | Assiut University | N/A |
| Terminated | Long-term Extension Study of Setrusumab in Adults With Type I, III, or IV Osteogenesis Imperfecta NCT05312697 | Ultragenyx Pharmaceutical Inc | Phase 2 |
| Active Not Recruiting | Setrusumab vs Placebo for Osteogenesis Imperfecta NCT05125809 | Ultragenyx Pharmaceutical Inc | Phase 2 / Phase 3 |
| Completed | Resilience and Coping in a Rare Skeletal Disease Population to Face Coronavirus (COVID-19) Outbreak Distress: NCT04844697 | Istituto Ortopedico Rizzoli | — |
| Completed | Study to Evaluate Romosozumab in Children and Adolescents With Osteogenesis Imperfecta NCT04545554 | Amgen | Phase 1 |
| Unknown | Results of Telescoping Nail In OI; a Case Series NCT04694144 | Assiut University | — |
| Completed | Osteogenesis Imperfecta Blood Pressure Study NCT04169568 | Nemours Children's Clinic | — |
| Completed | Evaluation of the Benefits of Adaptive Physical Activity in Children and Adolescents With Osteogenesis Imperfe NCT04119388 | Hospices Civils de Lyon | N/A |
| Recruiting | Effects of Bisphosphonates on OI-Related Hearing Loss NCT04152551 | Hospital for Special Surgery, New York | Phase 4 |
| Completed | Epigenetic Regulation of Osteogenesis Imperfecta Severity : miROI Study NCT04009733 | Hospices Civils de Lyon | N/A |
| Active Not Recruiting | Boost Brittle Bones Before Birth NCT03706482 | Karolinska Institutet | Phase 1 / Phase 2 |
| Completed | Experimental Evaluation of Back Braces for the Treatment of Spinal Deformity Produced With 3D Printing Technol NCT04282408 | IRCCS Eugenio Medea | N/A |
| Unknown | Boost to Brittle Bones - Stem Cell Transplantation for Treatment of Brittle Bones NCT04623606 | Christian Medical College, Vellore, India | Phase 1 / Phase 2 |
| Completed | Natural History of the Collagen-Related Disorder Osteogenesis Imperfecta and Genotype Phenotype Correlation NCT03575221 | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | — |
| Completed | Safety of Fresolimumab in the Treatment of Osteogenesis Imperfecta NCT03064074 | Baylor College of Medicine | Phase 1 |
| Withdrawn | An Exploratory Study of BPS804 Treatment in Adult Patients With Type I, III or IV Osteogenesis Imperfecta NCT03216486 | Ultragenyx Pharmaceutical Inc | Phase 2 |
| Completed | Pregnancy in Osteogenesis Imperfecta (OI) Registry NCT03072303 | University of South Florida | — |
| Completed | Do Bisphosphonates Alter the Skeletal Response to Mechanical Stimulation in Children With Osteogenesis Imperfe NCT03208582 | Sheffield Children's NHS Foundation Trust | Phase 2 |
| Completed | Treatment of Osteogenesis Imperfecta With Parathyroid Hormone and Zoledronic Acid NCT03735537 | University of Edinburgh | Phase 4 |
| Active Not Recruiting | Dental Malocclusion and Craniofacial Development in OI NCT02934451 | Baylor College of Medicine | — |
| Completed | Osteogenesis Imperfecta (OI) Quality of Life Survey Pilot Project 2 NCT02793063 | University of South Florida | — |
| Completed | High Resolution Thermal Imaging to Identify Vertebral Fractures in Children and Young People With Osteogenesis NCT04231916 | Sheffield Children's NHS Foundation Trust | N/A |
| Active Not Recruiting | Urinary Biomarkers of OI Pathobiology NCT02531087 | Baylor College of Medicine | — |
| Terminated | Multicenter,Single-arm Study to Evaluate Efficacy, Safety, & Pharmacokinetics of Denosumab in Children w/ OI NCT02352753 | Amgen | Phase 3 |
| Recruiting | BBD Longitudinal Study of Osteogenesis Imperfecta NCT02432625 | Baylor College of Medicine | — |
| Completed | NGS Strategy Effectiveness in Molecular Diagnosis NCT03557567 | Istituto Ortopedico Rizzoli | — |
| Completed | Mesenchymal Stem Cell Based Therapy for the Treatment of Osteogenesis Imperfecta NCT02172885 | Hospital de Cruces | Phase 1 |
| Terminated | Effects of a Physical Rehabilitation Program Using the Nintendo Wii on Children With Osteogenesis Imperfecta ( NCT02542540 | Centre Hospitalier Universitaire de Saint Etienne | N/A |
| Recruiting | Registry of Osteogenesis Imperfecta NCT04115774 | Luca Sangiorgi | — |
| Completed | Translational Therapy in Patients With Osteogenesis Imperfecta - A Pilot Trial on Treatment With the Rankl-Ant NCT01799798 | University of Cologne | Phase 2 |
| Terminated | The Effect of Treatment With Teriparatide and Zoledronic Acid in Patients With Osteogenesis Imperfecta NCT01679080 | University of Aarhus | Phase 2 |
| Completed | Effect of High-Dose Vitamin D on Bone Density in Osteogenesis Imperfecta NCT01713231 | Louis-Nicolas Veilleux Ph.D. | Phase 4 |
| Completed | Nutritional Interventional in Pediatric Patients With Osteogenesis Imperfecta NCT03841188 | Hospital de Clinicas de Porto Alegre | N/A |
| Completed | Whole Body Vibration Training in Children With Osteogenesis Imperfecta and Limited Mobility NCT03029312 | Birmingham Women's and Children's NHS Foundation Trust | N/A |
| Unknown | Development of a Non-invasive Assessment of Human Bone Quality Using Spatially Offset Raman Spectroscopy NCT02814591 | University College, London | — |
| Completed | Safety, Pharmacokinetics and Pharmacodynamics of BPS804 in Osteogenesis Imperfecta NCT01417091 | Ultragenyx Pharmaceutical Inc | Phase 2 |
| Completed | An Efficacy and Safety Trial of Intravenous Zoledronic Acid in Infants Less Than One Year of Age, With Severe NCT00982124 | Shriners Hospitals for Children | Phase 3 |
| Completed | Prevention of Post Operative Bone Loss in Children NCT00655681 | University of New Mexico | N/A |
| Completed | Efficacy and Safety of Alendronate in Chinese Children or Adolescents With Osteogenesis Imperfecta NCT02303873 | Peking Union Medical College Hospital | Phase 4 |
| Completed | Study of Teriparatide (FORTEO) to Treat Adults With Osteogenesis Imperfecta NCT00131469 | Oregon Health and Science University | Phase 4 |
| Completed | Safety and Efficacy of Risedronate in the Treatment of Osteogenesis Imperfecta in Children NCT00106028 | Warner Chilcott | Phase 3 |
| Completed | Zoledronic Acid in Children (1 -17 Years) With Severe Osteogenesis Imperfecta NCT00131118 | Novartis Pharmaceuticals | Phase 2 |
| Completed | Evaluation and Treatment of Patients With Connective Tissue Disease NCT00076830 | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | — |
| Completed | Marrow Mesenchymal Cell Therapy for Osteogenesis Imperfecta: A Pilot Study NCT00187018 | St. Jude Children's Research Hospital | N/A |
| Completed | Bisphosphonate Treatment of Osteogenesis Imperfecta NCT00063479 | Novartis Pharmaceuticals | Phase 2 |
| Completed | Pamidronate to Treat Osteogenesis Imperfecta in Children NCT00005901 | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Phase 3 |
| Completed | Bisphosphonate Therapy for Osteogenesis Imperfecta NCT00159419 | Indiana University School of Medicine | Phase 4 |
| Completed | Evaluation and Intervention for the Effects of Osteogenesis Imperfecta NCT00001594 | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | — |
| Completed | Treatment of Severe Osteogenesis Imperfecta by Allogeneic Bone Marrow Transplantation NCT00705120 | St. Jude Children's Research Hospital | Phase 1 |
| Completed | Growth Hormone Therapy in Osteogenesis Imperfecta NCT00001305 | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Phase 3 |