Trials / Terminated
TerminatedNCT02661828
Tapering Off Antidepressants
A Comparison of Two Antidepressant Tapering Regimens
- Status
- Terminated
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 2 (actual)
- Sponsor
- Emory University · Academic / Other
- Sex
- All
- Age
- 18 Years – 75 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to compare two ways to stop taking an antidepressant medication and determine whether a faster or slower taper is better tolerated.
Detailed description
As abrupt cessation of antidepressant medication can cause distressing symptoms (including and not limited to worsened mood, irritability/agitation, anxiety, dizziness, confusion, and headache), the aim of this study is to compare the tolerance of two tapering regimens with the hypothesis that tapering the antidepressant dose over the course of two weeks will yield less discontinuation symptoms than a one week taper regimen. Additionally, it is suspected that discontinuing medications that inhibit the serotonin transporter , such as selective serotonin reuptake inhibitors (SSRI) and serotonin norepinephrine reuptake inhibitors (SNRI) will have a greater difference in the frequency of discontinuation symptoms between the two and one-week tapering regimens versus antidepressants that don't inhibit serotonin transporter. Demographic and clinical features will also be identified that may predict discontinuation symptoms with the hypothesis that patients on SSRIs and SNRIs may experience more discontinuation symptoms versus patients on non-SSRI/SNRI medications. Whether or not the treatment duration is positively associated with the number of discontinuation symptoms will also be determined.
Conditions
- Major Depressive Disorder
- Anxiety Disorder
- Obsessive Compulsive Disorder
- Post-Traumatic Stress Disorder
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Two-Week Antidepressant Taper Regimen | Days 1-7: 50% of baseline antidepressant dose taken; Days 8-14: 25% of baseline antidepressant dose taken; Day 15: Stop antidepressant. |
| OTHER | One-Week Antidepressant Taper Regimen | Days 1-3: 50% of baseline antidepressant dose taken; Days 4-7: 25% of baseline antidepressant dose taken; Day 8: Stop antidepressant. |
Timeline
- Start date
- 2016-01-01
- Primary completion
- 2017-03-17
- Completion
- 2017-03-17
- First posted
- 2016-01-25
- Last updated
- 2018-09-25
- Results posted
- 2018-09-25
Locations
3 sites across 1 country: United States
Source: ClinicalTrials.gov record NCT02661828. Inclusion in this directory is not an endorsement.