NCT01151579

Effect of Nebulized Bronchodilators on Heart Rate

Prospective Trial of Effect of Nebulized Bronchodilators on Heart Rate and Arrhythmias in Critically Ill Adult Patients

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 89 (actual)
• Sponsor: Fahim Khorfan, MD · Industry
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to determine adverse events rates of nebulized albuterol versus levalbuterol among adult critically ill patients and determine if a differential exists in adverse events between the two drugs.

Detailed description

A randomized, single-blind, cross-over, prospective study was conducted in seventy critically ill adult patients with acute air flow obstruction. Patients were randomized to nebulized albuterol alternating with levalbuterol every 4 to 6 hours. Group A received albuterol 2.5 mg alternating with levalbuterol 0.63 mg. Group B received albuterol 2.5 mg alternating with levalbuterol 1.25 mg. All patients received nebulized ipratropium bromide 500 micrograms with each treatment. Heart rate and cardiac rhythm were continuously recorded before and 15 minutes after finishing each treatment. Any new rhythm abnormalities between treatments were also recorded.

Conditions

• COPD
• Sepsis
• Shock

Interventions

Type	Name	Description
DRUG	Levalbuterol	inhaled Levalbuterol 0.625 mg inhaled Levalbuterol 2.5 mg
DRUG	Albuterol	Nebulized albuterol 2.5mg

Timeline

• Start date: 2008-12-01
• Primary completion: 2009-11-01
• Completion: 2009-11-01
• First posted: 2010-06-28
• Last updated: 2015-10-23
• Results posted: 2015-10-23

Locations

1 site across 1 country: United States