| Not Yet Recruiting | Intraoperative Placement of Vancomycin-impregnated Calcium Sulfate Beads Conjugated With Analgesics to Improve NCT07201987 | Ganesh M. Shankar | Phase 2 |
| Enrolling By Invitation | Spine Registration Using 3D-Scanning NCT06267248 | Advanced Scanners Inc. | — |
| Not Yet Recruiting | ORI-Guided FiO₂ Titration in Prone Spine Surgery: Impact on Postoperative Atelectasis Assessed by Lung Ultraso NCT07375173 | Ankara Etlik City Hospital | N/A |
| Not Yet Recruiting | The MDK Study: Using a Combination of Methadone-dexmedetomidine-ketamine for Postoperative Pain Control in Pat NCT07365800 | University of Missouri-Columbia | Phase 4 |
| Recruiting | An Open, Parallel-group, Randomized, Medical Device Study to Assess the Usability and Performance of Surgify H NCT06827795 | Surgify Medical Oy | N/A |
| Recruiting | Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery NCT07344467 | Tanta University | N/A |
| Recruiting | Effect of Magnesium on Neuromonitoring NCT06975072 | University of California, San Francisco | Phase 4 |
| Completed | Product Surveillance Registry; Ear, Nose &Amp; Throat - NIM Vital Cohort NCT06637995 | Medtronic | — |
| Recruiting | Minimum Effective Dose of Incisional Local Infiltration Betamethasone for the Prevention of Pain After Spinal NCT06785350 | Beijing Tiantan Hospital | N/A |
| Recruiting | Irrisept Solution for Instrumented Spine Surgery NCT06439953 | Rhode Island Hospital | N/A |
| Completed | Hemodynamic Effects of Fentanyl Vs Dexmedetomidine in Spine Surgery NCT07238101 | Universitas Sumatera Utara | Phase 4 |
| Withdrawn | 3rd-year Post-surgical Evaluation of Adjacent Segment Disc Degeneration Onset in Lumbar Spine (Spinal Fusion v NCT05561322 | Centre Hospitalier Universitaire de Nīmes | — |
| Enrolling By Invitation | Influence of Pre-operative Back Muscle Exercise on Post-operative Outcomes After Spine Surgery NCT06808022 | University of California, San Diego | N/A |
| Completed | Propofol-Fentanyl-Dexmedetomidine and Propofol-Fentanyl-Sevoflurane Anesthesia for Major Spine Surgery Under S NCT06210061 | Ain Shams University | N/A |
| Withdrawn | Postoperative Oral Methadone After Major Spine Surgery; Safety, Feasibility and Efficacy in Prevention of Prog NCT05693675 | The University of Texas Health Science Center, Houston | Phase 2 / Phase 3 |
| Unknown | Fusion Status After ACDF NCT05986006 | Rothman Institute Orthopaedics | N/A |
| Enrolling By Invitation | Sugammadex vs Neostigmine/Glycopyrrolate on Urinary Retention After Spine Surgery NCT05887375 | University of Missouri-Columbia | Phase 4 |
| Unknown | Lidocaine Infusion With ANI Monitoring in Spine Surgery. NCT05103215 | Kaohsiung Medical University Chung-Ho Memorial Hospital | Phase 4 |
| Unknown | Pregabalin is an Effective Treatment for Acute Postoperative Pain Following Spinal Surgery Without Major Side NCT05478382 | Ajou University School of Medicine | Phase 4 |
| Terminated | Effects of Continuous ESP Catheters on Recovery, Pain and Opioid Consumption After Multilevel Spine Surgery NCT05494125 | Hospital for Special Surgery, New York | N/A |
| Completed | Use of Surgify Safety Burr in Hard Tissue Cutting, Head and Spine Area NCT05269836 | Surgify Medical Oy | — |
| Terminated | Evaluation of an Enhanced Recovery Protocol After Minimally Invasive Lumbar Surgery. NCT05015036 | GCS Ramsay Santé pour l'Enseignement et la Recherche | — |
| Unknown | Incidence , Risk Factors and Outcomes of Haemodynamic Instability and Cardiac Arrest During Spine Surgery NCT05131854 | Zagazig University | — |
| Unknown | Changes of Intra Abdominal Pressure During Surgeries in Prone Position as a Marker of Renal Damage NCT05626868 | Medical University of Warsaw | — |
| Unknown | Randomized Trial of Intraoperative IV Versus Preoperative Oral Acetaminophen During Ambulatory Lumbar Discecto NCT04574778 | Rothman Institute Orthopaedics | Phase 3 |
| Completed | Combined IV and Topical TXA in Major Spine Surgery NCT04797156 | Icahn School of Medicine at Mount Sinai | EARLY_Phase 1 |
| Unknown | Effect of TIVA With Magnesium Sulfate on IONM in Patients Undergoing Spine Surgery NCT04716439 | King Khalid University Hospital | — |
| Completed | Effect of Protein Supplement on Paraspinal Muscles in Spine Surgery NCT04300517 | Shahid Beheshti University | N/A |
| Completed | Intravenous Methocarbamol for Acute Pain After Spine Surgery NCT06659965 | The University of Texas Health Science Center, Houston | — |
| Completed | Erectus Nerve Block for Lumbar Spine Surgery NCT04473508 | Centre Hospitalier Universitaire de Nīmes | Phase 3 |
| Completed | Trial of Protein Supplement on Vertebral Fusion in Posterior Spine Fusion Surgery NCT04091841 | Shahid Beheshti University | N/A |
| Completed | Scheme of Limb Warming Blanket Combined With Dexmedetomidine NCT05857410 | Jincheng General Hospital | N/A |
| Enrolling By Invitation | Tranexamic Acid Infusion During Elective Spine Surgery NCT04312880 | Albany Medical College | Phase 4 |
| Completed | Evaluation of Open-Label Conditioned Placebo Analgesia for Postoperative Opioid Reduction Following Spinal Fus NCT04574388 | Brigham and Women's Hospital | N/A |
| Completed | Use of CADISS Medical Device to Facilitate Dissection of Epidural Fibrosis in Revision Spine Surgery NCT05016739 | AuXin Surgery SA | N/A |
| Completed | Pregabalin Effects on Hypotensive Anesthesia During Spine Surgery. NCT03301025 | Mansoura University | N/A |
| Completed | Speed of Recovery of Reversal of Neuromuscular Blockade in Geriatric Patients Undergoing Spine Surgery NCT03112993 | University of Missouri-Columbia | Phase 4 |
| Completed | Enhanced Recovery After Spine Surgery NCT02949518 | Hospital for Special Surgery, New York | N/A |
| Completed | Transverse Abdominis Plane Block for Anterior Approach Spine Surgery NCT02884440 | Rennes University Hospital | Phase 2 |
| Terminated | Effectiveness of ROTEM-based Coagulation Surveillance on Reducing Blood Product Utilization During Complex Spi NCT02758184 | Duke University | N/A |
| Completed | Comprehensive Spinal Alignment Planning Study NCT02606695 | NuVasive | — |
| Unknown | "Efficacy of Hybrid Systems ("Topping Off") Versus Rigid Spinal Fusion in Lumbar Fusion Surgery: A Dual-center NCT02551302 | University of Cologne | N/A |
| Completed | Performance of Flexible Self-adherent Absorbent Dressing Coated With a Soft Silicone Layer After Hip -,Knee- A NCT02771015 | University of Cologne | N/A |
| Terminated | Mindfulness Meditation for Spine Surgery Pain NCT02104349 | Icahn School of Medicine at Mount Sinai | N/A |
| Completed | Radiological and Clinical Efficacy of a Hybrid Spinal Implant ("Topping Off"): a Mono-center, Prospective Clin NCT03404232 | University Hospital, Aachen | N/A |
| Completed | Risk Factors Associated With Infection After Spine Surgery NCT05740865 | Xuanwu Hospital, Beijing | — |
| Completed | Prophylactic Application of an Incisional Wound Vac to Prevent Wound Complications in Obese Spine Surgery Pati NCT02926924 | University of Michigan | N/A |
| Completed | Establishment of Optimal Transfusion Threshold During Spine Surgery NCT00967109 | Rigshospitalet, Denmark | N/A |
| Terminated | Motor Evoked Potentials and SedLine NCT00805844 | University of California, San Francisco | — |
| Completed | Perioperative Intravenous Lidocaine or Epidural Anesthesia on Outcomes in Complex Spine Surgery NCT00840996 | The Cleveland Clinic | N/A |
| Completed | Influence of Dexmedetomidine on the Evoked Potentials During Spine Surgery NCT00494832 | University of Washington | N/A |
| Completed | Does Pre-operative Carbohydrate Loading Reduce Insulin Resistance and Improve Outcomes in Elective Surgical Pa NCT00618592 | Unity Health Toronto | N/A |
| Completed | Laryngeal Mask Use in Knee-chest Position in Lumbar Surgery in Neurosurgical Patients NCT02162368 | Fundacion Clinic per a la Recerca Biomédica | — |
| Terminated | Intraocular Pressure During Prone Spinal Surgery NCT00176722 | University of Medicine and Dentistry of New Jersey | — |
| Terminated | Direct Stimulation Of Spinal Nerve Roots To Determine Sensory And Motor Innervation Patterns NCT00696501 | Lahey Clinic | — |
| Completed | Use of Spinal Sealant System During Spinal Surgery NCT00458354 | M.D. Anderson Cancer Center | Phase 3 |
| Completed | Preoperative Prevention and Early Rehabilitation for Patients Undergoing Elective Spine Surgery NCT00459966 | Rigshospitalet, Denmark | N/A |
| Completed | Safety of Tranexamic Acid in Reducing Bleeding in Adults Undergoing Spinal Surgery NCT00444470 | University Health Network, Toronto | Phase 3 |