NCT05478382

Pregabalin is an Effective Treatment for Acute Postoperative Pain Following Spinal Surgery Without Major Side Effects

Efficacy and Side Effect Profile of Varying Dose of Pregabalin for the Treatment of Acute Postoperative Pain Following Spinal Surgery

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 132 (estimated)
• Sponsor: Ajou University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The objective of this study is to examine the efficacy and side effect of varying dose of pregabalin for the treatment of postoperative pain after spinal surgery.

Detailed description

Patients experience considerable postoperative pain after spine surgery. Because the spine is located at the center of the body and supports body weight, severe postoperative pain hinders upper body elevation and gait which can lead to various complications such as pulmonary deterioration or pressure sores. It is important to effectively control postoperative pain to prevent such complications. Gabanoids are widely used as preemptive multimodal analgesia while their effects and side effects are known to be dose dependent. The objective of this study is to examine the efficacy and side effect of varying dose of pregabalin for the treatment of postoperative pain after spinal surgery.

Conditions

• Postoperative Pain
• Pregabalin
• Spine Surgery
• Adverse Reaction to Pregabalin

Interventions

Type	Name	Description
DRUG	Pregabalin 25 MG	Patients are given 0 to 3 capsules per administration according to their allocated group.
DRUG	Placebo	Patients are given 0 to 3 capsules per administration according to their allocated group.

Timeline

• Start date: 2022-10-01
• Primary completion: 2025-12-31
• Completion: 2025-12-31
• First posted: 2022-07-28
• Last updated: 2022-07-28