| Not Yet Recruiting | Retinoblastoma Consolidation in Egyptians NCT07530458 | Assiut University | — |
| Recruiting | Detailed Phenotypic and Genotype Study to Correlate RB1 Mutations Relating to Primary Ocular Tumors and Second NCT06725173 | University of Washington | — |
| Recruiting | High-dose Topotecan for Retinoblastoma With Recurrent or Refractory Vitreous Seed NCT06972602 | Eye & ENT Hospital of Fudan University | EARLY_Phase 1 |
| Recruiting | Retinoblastoma Phase II Expanded Access Clinical Trial NCT06679634 | Targeted Therapy Technologies, LLC | Phase 2 |
| Recruiting | Targeting NUDT21 siRNA Drugs for Patients With Refractory Retinoblastoma NCT06424301 | Eye & ENT Hospital of Fudan University | EARLY_Phase 1 |
| Recruiting | Trilateral Retinoblastoma: Incidence and Outcomes NCT06367530 | Amsterdam UMC, location VUmc | — |
| Enrolling By Invitation | Cognitive Functioning and Health Related Quality of Life in Retinoblastoma Survivors NCT06227962 | Amsterdam University Medical Center | — |
| Recruiting | GPC2 CAR T Cells for Relapsed or Refractory Neuroblastoma and Metastatic Retinoblastoma NCT05650749 | Stephan Grupp MD PhD | Phase 1 |
| Unknown | Treatment of Intraocular Retinoblastoma NCT05028270 | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | — |
| Withdrawn | Photoscreening for Retinoblastoma NCT04344652 | Phoenix Children's Hospital | N/A |
| Unknown | A Clinical Study on the Efficacy and Safety of VEC Intravenous Chemotherapy Combined With Conbercept Intravitr NCT04990271 | Chengdu Kanghong Biotech Co., Ltd. | Phase 2 |
| Unknown | Topotecan Episcleral Plaque for Treatment of Retinoblastoma NCT04156347 | Targeted Therapy Technologies, LLC | Phase 1 |
| Recruiting | Ocular Conservative Treatment for Retinoblastoma : Efficacy of the New Management Strategies and Visual Outcom NCT04681417 | Institut Curie | Phase 2 / Phase 3 |
| Recruiting | Topotecan and Melphalan for Retinoblastoma NCT04799002 | Sun Yat-sen University | Phase 3 |
| Unknown | Effect of Anesthetic Drugs on Neurocognitive Function in Children With Retinoblastoma Requiring Multiple Anest NCT04700514 | Seoul National University Hospital | N/A |
| Recruiting | Therapeutic Recommendations For The Treatment Of Children With A Retinoblastoma NCT04425434 | French Africa Pediatric Oncology Group | — |
| Recruiting | Adjuvant Chemotherapy for High-risk Postenucleation Retinoblastoma NCT05080010 | Sun Yat-sen University | Phase 3 |
| Unknown | Nitroglycerin for Intra-arterial Chemotherapy in Pediatric Retinoblastoma. NCT04564521 | Seoul National University Hospital | N/A |
| Completed | Intra-arterial Chemotherapy for Retinoblastoma NCT04342572 | Washington University School of Medicine | Phase 1 |
| Active Not Recruiting | B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults NCT04483778 | Seattle Children's Hospital | Phase 1 |
| Completed | Topotecan Episcleral Plaque for Treatment of Retinoblastoma NCT04428879 | The Hospital for Sick Children | Phase 1 |
| Unknown | Autonomic Reflexes During Intra-arterial Chemotherapy for Retinoblastoma NCT04451304 | Federal University of São Paulo | — |
| Unknown | Deep Learning in Retinoblastoma Detection and Monitoring. NCT05308043 | Beijing Tongren Hospital | — |
| Completed | Mobile Health Case Management System for Reducing Pediatric Treatment Abandonment NCT03677128 | Duke University | N/A |
| Active Not Recruiting | EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults NCT03618381 | Seattle Children's Hospital | Phase 1 |
| Recruiting | Studying Health Outcomes After Treatment in Patients With Retinoblastoma NCT03932786 | Vanderbilt-Ingram Cancer Center | — |
| Completed | New Strategies to Detect Cancers in Carriers of Mutations in RB1 NCT04164134 | Amsterdam UMC, location VUmc | — |
| Enrolling By Invitation | Early Check: Expanded Screening in Newborns NCT03655223 | RTI International | — |
| Recruiting | Determining Whether Multiple Anesthesia Exposures Affect Cognitive Function for Retinoblastoma Patients NCT03546387 | Memorial Sloan Kettering Cancer Center | — |
| Terminated | Determination of the Sensitivity and Specificity of a Smartphone Application to Detect Retinoblastoma NCT03016156 | St. Jude Children's Research Hospital | N/A |
| Unknown | RCT of Ballon Technique VS Selective Ophthalmic Artery Infusion For the Retinoblastoma Patients NCT03439397 | Guangzhou Women and Children's Medical Center | N/A |
| Recruiting | Can Pretreatment MRI be Used to Predict Intra-arterial Chemotherapy Response in Retinoblastoma? NCT03267459 | Fondation Ophtalmologique Adolphe de Rothschild | — |
| Unknown | Severe and Transient Hypoxemia During Selective Intra-arterial Chemotherapy for Retinoblastoma in Children: Ev NCT03559894 | Christian Kern | — |
| Recruiting | Familial Investigations of Childhood Cancer Predisposition NCT03050268 | St. Jude Children's Research Hospital | — |
| Recruiting | RB Liquid Biopsy Biorepository NCT04959097 | Children's Hospital Los Angeles | — |
| Completed | Intravitreal Carboplatin for the Treatment of Participants With Recurrent or Refractory Intraocular Retinoblas NCT02792036 | St. Jude Children's Research Hospital | Phase 1 |
| Unknown | G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tum NCT02933333 | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | Phase 4 |
| Completed | Superselective Intra-arterial Chemotherapy Treatment for Retinoblastoma- 5 Year Results From Turkey NCT03935074 | Istanbul University - Cerrahpasa | — |
| Withdrawn | Performance of a Photoscreener for Vision Screening in a Haitian Pediatric Population NCT02655432 | Université de Montréal | — |
| Terminated | PCI Imaging System in Pediatric Ophthalmology NCT02617862 | Brenda Gallie | N/A |
| Completed | Simvastatin With Topotecan and Cyclophosphamide in Relapsed and/or Refractory Pediatric Solid and CNS Tumors NCT02390843 | Emory University | Phase 1 |
| Completed | Feasibility of Generating Pluripotent Stem Cells From Patients With Familial Retinoblastoma NCT02193724 | St. Jude Children's Research Hospital | — |
| Unknown | SPT Screening in Irradiated Hereditary Retinoblastoma Survivors NCT02329002 | Amsterdam UMC, location VUmc | — |
| Terminated | Alternating Systemic Chemotherapy and Intra-Arterial Melphalan (IAM) Chemotherapy in Children With Intra-Ocula NCT02116959 | University of California, San Francisco | Phase 1 |
| Completed | Cardio-respiratory Events During Ophthalmic Artery Chemotherapy for Retinoblastoma Under a Deep Anesthesia NCT02764398 | Fondation Ophtalmologique Adolphe de Rothschild | — |
| Completed | Morphological Analysis of the Pineal Gland in Pediatric Retinoblastoma Patients Using Magnetic Resonance Imagi NCT01884194 | Charite University, Berlin, Germany | — |
| Active Not Recruiting | Adjuvant Chemotherapy for High-risk Retinoblastoma After Enucleation NCT01906814 | Sun Yat-sen University | Phase 3 |
| Terminated | Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With NCT01987596 | Barbara Ann Karmanos Cancer Institute | Phase 3 |
| Unknown | Efficacy Study of Lucentis in the Treatment of Retinoblastoma NCT01899066 | Sun Yat-sen University | Phase 2 |
| Active Not Recruiting | Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma NCT01783535 | St. Jude Children's Research Hospital | Phase 2 |
| Completed | Attention to Retinoblastoma Diagnosed in the Trauma Setting NCT03764930 | Sun Yat-sen University | — |
| Completed | Anti-Angiogenic Therapy Post Transplant (ASCR) for Pediatric Solid Tumors NCT01661400 | Washington University School of Medicine | Phase 1 |
| Completed | Evaluation of MRI of the Pineal Gland in Retinoblastoma NCT06367569 | Amsterdam UMC, location VUmc | — |
| Terminated | Cancer Biology of Retinoblastoma NCT01642823 | Stanford University | — |
| Terminated | Intravitreal Injections of Melphalan for Retinoblastoma NCT01558960 | Hadassah Medical Organization | N/A |
| Terminated | Phase II Study Temozolomide for Retinoblastoma Metastatic to the Central Nervous System for Patients From Guat NCT01857752 | Stanford University | Phase 2 |
| Active Not Recruiting | Conservative Treatments of Retinoblastoma NCT02866136 | Institut Curie | Phase 2 |
| Completed | Auto Transplant for High Risk or Relapsed Solid or CNS Tumors NCT01505569 | Masonic Cancer Center, University of Minnesota | N/A |
| Terminated | A Study of Intra-Ophthalmic Artery Topotecan Infusion for the Treatment of Retinoblastoma NCT01466855 | Children's Hospital Medical Center, Cincinnati | EARLY_Phase 1 |
| Unknown | Intra-arterial Chemotherapy for Children With Retinoblastoma NCT00906113 | Hadassah Medical Organization | Phase 1 / Phase 2 |
| Completed | Aflac ST0901 CHOANOME - Sirolimus in Solid Tumors NCT01331135 | Emory University | Phase 1 |
| Terminated | Intra-arterial Chemotherapy for the Treatment of Intraocular Retinoblastoma NCT01293539 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Phase 2 |
| Completed | Use of Racotumomab in Patients With Pediatric Tumors Expressing N-glycolylated Gangliosides NCT01598454 | Laboratorio Elea Phoenix S.A. | Phase 1 |
| Completed | Photodynamic Therapy With Visudyne for Human Retinoblastoma: A Preliminary Study NCT04429139 | Sun Yat-sen University | N/A |
| Withdrawn | Intra-arterial Chemotherapy for Advanced Intraocular Retinoblastoma NCT01151748 | Stanford University | Phase 2 |
| Withdrawn | Pilot Study of Topotecan/Vincristine With Subconjunctival Carboplatin for Patients With Bilateral Retinoblasto NCT00980551 | Children's Hospital Medical Center, Cincinnati | N/A |
| Recruiting | Comprehensive Omics Analysis of Pediatric and Adult Solid Tumors and Establishment of a Repository for Related NCT01109394 | National Cancer Institute (NCI) | — |
| Active Not Recruiting | Adjuvant Treatment in Extensive Unilateral Retinoblastoma Primary Enucleated (RB SFCE 2009) NCT02870907 | Institut Curie | Phase 2 |
| Terminated | Intra-arterial Chemotherapy With Melphalan for the Treatment of Retinoblastoma (RTB) in Advanced Intraocular S NCT01393769 | Hospital Sant Joan de Deu | Phase 2 |
| Completed | Seneca Valley Virus-001 and Cyclophosphamide in Treating Young Patients With Relapsed or Refractory Neuroblast NCT01048892 | Children's Oncology Group | Phase 1 |
| Completed | CEV With/Without Periocular Carboplatin Chemotherapy for Extraocular Retinoblastoma NCT02319486 | Sun Yat-sen University | Phase 4 |
| Completed | A Study of the Effectiveness of a Local Injection of Chemotherapy for Retinoblastoma NCT00857519 | Wills Eye | N/A |
| Active Not Recruiting | Retinoblastoma Survivor Study: Assessment of General Health and Quality of Life NCT00639301 | Memorial Sloan Kettering Cancer Center | — |
| Completed | Molecular Analysis of Retinoblastoma NCT00718783 | St. Jude Children's Research Hospital | — |
| Completed | Collecting and Storing Tissue From Young Patients With Cancer NCT00898755 | Children's Oncology Group | — |
| Completed | Phase I Trial of Periocular Topotecan in Retinoblastoma NCT00460876 | Hospital JP Garrahan | Phase 1 |
| Terminated | Proton Beam Radiation Therapy for Intraocular and Periocular Retinoblastoma NCT00432445 | M.D. Anderson Cancer Center | Phase 2 |
| Completed | Intra-arterial Chemotherapy(Chemosurgery) for Retinoblastoma NCT00901238 | Weill Medical College of Cornell University | Phase 1 / Phase 2 |
| Completed | Efficacy of Prophylactic Itraconazole in High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transpl NCT00336531 | Samsung Medical Center | Phase 4 |
| Unknown | Quality of Life in Children Cured of Retinoblastoma NCT00278031 | Hadassah Medical Organization | — |
| Completed | Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal NCT00445965 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Unknown | Carboplatin Periocular Injection for Retinoblastoma NCT02137928 | Sun Yat-sen University | Phase 3 |
| Unknown | Chemotherapy With or Without Radiation Therapy or Observation in Treating Young Patients With Advanced Retinob NCT00360750 | Children's Cancer and Leukaemia Group | N/A |
| Terminated | MT2004-30: Tomotherapy for Solid Tumors NCT00623077 | Masonic Cancer Center, University of Minnesota | Phase 1 |
| Completed | Study of Treatment for Patients With Cancer of the Eye -Retinoblastoma NCT00186888 | St. Jude Children's Research Hospital | Phase 3 |
| Active Not Recruiting | Combination Chemotherapy and Cyclosporine Followed by Focal Therapy for Bilateral Retinoblastoma NCT00110110 | The Hospital for Sick Children | Phase 2 |
| Completed | Research on the Environment and Children's Health: Retinoblastoma NCT00582049 | Memorial Sloan Kettering Cancer Center | — |
| Completed | Chemotherapy and Stem Cell Transplantation in Treating Children With Central Nervous System Cancer NCT00053118 | Roswell Park Cancer Institute | Phase 1 |
| Completed | Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors NCT00024258 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Completed | Busulfan in Treating Children and Adolescents With Refractory CNS Cancer NCT00006246 | Pediatric Brain Tumor Consortium | Phase 1 |
| Completed | Rebeccamycin Analogue in Treating Children With Solid Tumors or Non-Hodgkin's Lymphoma NCT00006102 | National Cancer Institute (NCI) | Phase 2 |
| Terminated | Amifostine to Protect From Side Effects of PSCT in Treating Patients With Solid Tumors NCT00003926 | Masonic Cancer Center, University of Minnesota | Phase 1 |
| Completed | Combination Chemotherapy, Radiation Therapy, and Bone Marrow Transplantation in Treating Patients With Retinob NCT00004006 | St. Jude Children's Research Hospital | Phase 2 |
| Withdrawn | Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Brain NCT00003273 | NYU Langone Health | Phase 2 |
| Completed | High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors NCT00003173 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Completed | Monoclonal Antibody Therapy in Treating Patients With Leptomeningeal Cancer NCT00003022 | Memorial Sloan Kettering Cancer Center | Phase 1 |
| Completed | Chemotherapy Treatment for Children With Intraocular Germ-Line Retinoblastoma NCT00179920 | Ann & Robert H Lurie Children's Hospital of Chicago | Phase 2 |
| Completed | Carboplatin Plus Vincristine in Treating Children With Retinoblastoma NCT00002794 | St. Jude Children's Research Hospital | Phase 2 |
| Completed | Chemotherapy in Treating Patients With Retinoblastoma NCT00002675 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Completed | Retinoblastoma Biomarker Study NCT00342797 | National Cancer Institute (NCI) | — |
| Completed | Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Rare Cancer NCT00002515 | Memorial Sloan Kettering Cancer Center | Phase 2 |