| Not Yet Recruiting | An Exploratory Study of the Potential for Rational Immune System Manipulation to Prevent Emergence of Synuclei NCT06996652 | Yale University | Phase 2 |
| Not Yet Recruiting | Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic NCT06644573 | Nyree Penn | Phase 1 |
| Recruiting | Unmet Needs Among Patients With Isolated REM Sleep Behavior Disorder (iRBD) and Their Significant Others NCT07498452 | Universita di Verona | — |
| Recruiting | The Impact of Light, Electrical, and Magnetic Neuroregulation Interventions on Sleep-wake Disorders NCT06797284 | Second Affiliated Hospital of Soochow University | N/A |
| Recruiting | IMPACT 360 for Parkinson's Disease NCT07443293 | University of British Columbia | Phase 2 |
| Recruiting | Artificial Intelligence in Molecular Imaging: Predicting Parkinson's Risk in REM Sleep Behavior Disorder NCT06629207 | Insel Gruppe AG, University Hospital Bern | N/A |
| Recruiting | Behavioral Treatment for Nightmares in REM Sleep Behavior Disorder NCT06441864 | University of Utah | N/A |
| Recruiting | The COSP-RBD Study: Concussions and Contact Sports in RBD vs Controls NCT06270290 | Guy's and St Thomas' NHS Foundation Trust | — |
| Recruiting | Identification of Prodromal Neurodegeneration in Serotonergic-Induced REM Sleep Behavior Disorder NCT06467461 | University of Minnesota | N/A |
| Recruiting | Slow-SPEED-NL: Slowing Parkinson's Early Through Exercise Dosage-Netherlands NCT06193252 | Radboud University Medical Center | N/A |
| Unknown | DREAMER - IsolateD REM Sleep Without Atonia as a Risk Factor for REM Sleep Behavior disordER NCT06140511 | Oasi Research Institute-IRCCS | — |
| Active Not Recruiting | Effect of PXS-4728A on Microglia Activation in Participants With Isolated Rapid Eye Movement Sleep Behaviour D NCT05904717 | Syntara | Phase 2 |
| Recruiting | Implementing a National Biobank of PD With WGS and Functional Assessment of Polygenic Inheritance by iPSC Tech NCT05721911 | IRCCS San Raffaele | — |
| Enrolling By Invitation | MIBG in Aging and Neurologic Disorders NCT05514106 | Mayo Clinic | Phase 4 |
| Withdrawn | Efficacy and Safety of Rasagiline in Prodromal Parkinson's Disease NCT05611372 | Second Affiliated Hospital, School of Medicine, Zhejiang University | Phase 2 / Phase 3 |
| Active Not Recruiting | Terazosin and Parkinson's Disease Extension Study NCT05109364 | Cedars-Sinai Medical Center | Phase 2 |
| Recruiting | North American Prodromal Synucleinopathy Consortium Stage 2 NCT05826457 | Washington University School of Medicine | — |
| Recruiting | Intestinal Immunity in Neurologic Disease NCT06329453 | Yale University | — |
| Recruiting | Neuroplasticity in RBD NCT05471960 | University of Minnesota | N/A |
| Suspended | Effects of Tablet Computer-based Cognitive Training in Patients With Idiopathic REM Sleep Behavior Disorder NCT05256836 | Seoul National University Hospital | N/A |
| Recruiting | Gut Microbiota in the Progression of Alpha-synucleinopathies NCT05353868 | Chinese University of Hong Kong | — |
| Recruiting | Prodromal Markers in Recurrent Dream Enactment Behaviors Without REM Sleep Without Atonia NCT05353881 | Chinese University of Hong Kong | — |
| Active Not Recruiting | Terazosin Effect on Cardiac Changes in Early Parkinson's Disease NCT04386317 | Cedars-Sinai Medical Center | Phase 2 |
| Recruiting | PREdictive Risk Factors of Conversion Into Idiopathic RBD. Italian Study NCT05262543 | University of Cagliari | — |
| Withdrawn | A Study of Efficacy and Safety of Idebenone Vs. Placebo in Prodromal Parkinson Disease NCT04152655 | Second Affiliated Hospital, School of Medicine, Zhejiang University | Phase 2 / Phase 3 |
| Active Not Recruiting | Cardiac Changes in Early Parkinson's Disease: A Follow up Study NCT04218968 | Cedars-Sinai Medical Center | Phase 2 |
| Completed | Treatment of REM Sleep Behavior Disorder (RBD) With Sodium Oxybate NCT04006925 | Stanford University | Phase 4 |
| Unknown | French Validation of a Severity Scale in REM Sleep Behavior Disorder (SEV-TCSP) NCT04071899 | University Hospital, Clermont-Ferrand | — |
| Unknown | Search for Biomarkers of Neurodegenerative Diseases in Idiopathic REM Sleep Behavior Disorder NCT04048603 | Chinese University of Hong Kong | — |
| Active Not Recruiting | Adrenergic Blockers for Cardiac Changes in Early Parkinson's Disease (Protocol 53136) NCT03775096 | Michele Tagliati, MD | Phase 2 |
| Completed | Parkinson's Disease Biomarker Study NCT06812702 | Ronald Postuma | — |
| Completed | Progression of Prodromal Markers of α-synucleinopathy Neurodegeneration in the FDRs of Patients With RBD NCT03671772 | Chinese University of Hong Kong | — |
| Enrolling By Invitation | North American Prodromal Synucleinopathy Consortium NCT03623672 | Washington University School of Medicine | — |
| Completed | Quantitative Mapping of Substantia Nigra Iron in Parkinson's Disease (Stages I-IV, REM Sleep Behavior Disorder NCT03675282 | Weill Medical College of Cornell University | Phase 1 / Phase 2 |
| Completed | Gut Microbiota Across Early Stages of Synucleinopathy: From High-risk Relatives, REM Sleep Behavior Disorder t NCT03645226 | Chinese University of Hong Kong | — |
| Completed | Efficacy and Safety of Melatonin and Clonazepam for IRBD NCT03255642 | Kyung Hee University Hospital at Gangdong | N/A |
| Completed | Striatal Dopamine Transmission in Individuals With Isolated Rapid Eye Movement Sleep With Atonia: a Search for NCT03353207 | Chinese University of Hong Kong | — |
| Completed | Prodromal Markers of First-degree Relatives of Patients With Psychiatric Disorders Comorbid With RBD NCT03595475 | Chinese University of Hong Kong | — |
| Unknown | Detecting Parkinson's Disease Through Speech Analysis NCT03133611 | Czech Technical University in Prague | N/A |
| Unknown | Evolution of RBD in PD NCT03047408 | University Hospital, Clermont-Ferrand | N/A |
| Terminated | Open-label Study of Nelotanserin in Lewy Body Dementia With Visual Hallucinations or REM Sleep Behavior Disord NCT02871427 | Axovant Sciences Ltd. | Phase 2 |
| Unknown | Efficacy and Safety of Melatonin PR and Clonazepam in Patients With REM Sleep Behavior Disorder in Parkinson D NCT02789592 | Seoul National University Hospital | Phase 2 |
| Completed | Study Evaluating Nelotanserin for Treatment of REM Sleep Behavior Disorder in Subjects With Dementia (DLB or P NCT02708186 | Axovant Sciences Ltd. | Phase 2 |
| Completed | Retinal Abnormalities as Biomarker of Disease Progression and Early Diagnosis of Parkinson Disease NCT02640339 | NYU Langone Health | — |
| Unknown | Investigation of Clinical Feature and Brain Function in Narcoleptic Patients NCT03376568 | Tang-Du Hospital | — |
| Unknown | Effect of Slow-release Melatonin (Circadin®) Therapy on Idiopathic RBD: a Pilot Study NCT02836743 | Seoul National University Hospital | Phase 4 |
| Completed | Exploration of the Reward System by Functional MRI in Parkinson's Disease Patients With and Without REM Sleep NCT02824341 | University Hospital, Clermont-Ferrand | N/A |
| Unknown | Ultra High Field Magnetic Resonance Imaging as a Biomarker for Premotor Parkinson's Disease NCT03288909 | Oregon Health and Science University | — |
| Completed | Effect of Clonazepam on REM Sleep Behavior Disorder in Patients With Parkinsonism NCT02312908 | Seoul National University Hospital | Phase 2 |
| Unknown | Establish a National Registry of REM Sleep Behavior Disorder NCT03671798 | Chinese University of Hong Kong | — |
| Unknown | Familial Aggregation and Biomarkers in REM Sleep Behaviour Disorder. NCT03660982 | Chinese University of Hong Kong | — |
| Terminated | Gait and REM Sleep Behavior Disorder NCT02554331 | University Hospital, Montpellier | N/A |
| Completed | Brain Imaging in the Idiopathic REM Sleep Behavior Disorder (ALICE) NCT03072940 | Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil | — |
| Completed | Prospective Neuroimaging Investigation of Idiopathic REM Sleep Behavior Disorder NCT02984137 | Seoul National University Hospital | N/A |
| Unknown | Understanding the Natural History of REM Sleep Behavior Disorder NCT01674998 | The Parkinson's Institute | — |
| Completed | MRI Study of Brain Activity in Healthy Adults and Individuals With Parkinsonism and Rapid Eye Movement Disorde NCT01547481 | University of Alabama at Birmingham | — |
| Enrolling By Invitation | DaTSCAN Imaging in Aging and Neurodegenerative Disease NCT01453127 | Mayo Clinic | Phase 4 |
| Recruiting | Natural History Study of Synucleinopathies NCT01799915 | NYU Langone Health | — |
| Completed | Study to Determine Whether Ramelteon Helps People With REM Sleep Behavior Disorder NCT01401413 | Sleep Medicine Centers of WNY | Phase 4 |