NCT03376568

Investigation of Clinical Feature and Brain Function in Narcoleptic Patients

Feature of Polysomnography and Cerebral Metabolism and Function in Narcolepsy With/Without RBD and Control Subject

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Tang-Du Hospital · Academic / Other
• Sex: All
• Age: 10 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This study evaluates the PSG and cerebral metabolism and functions in narcolepsy with/without RBD

Detailed description

Polysomnographic (PSG) work-up one night to record nocturnal sleep condition in narcolepsy with /without RBD and control subjects including sleep macrostructure, occurrence of sleep onset rapid eye movement period(SOREMP), sleep stages distribution, and sleep arousle and leg movement and apnea hyponea index would be calculated. Functional magnetic resonance imaging (fMRI) has been used in human to nonivasiverlyn investigate the neural mechanisms. This technique also apply to measures the variations in brain perfusion, structure and morphology in narcolepsy patients by assessing the blood oxygen level-dependent (BOLD) signal diffusion tensor imaging (DTI and voxel-based morphometry(VBM) This study compare the feature of PSG and fMRI between narcolepsy with RBD, narcolepsy without RBD, control subject to evaluates the PSG and cerebral metabolism and functions in narcolepsy with/without RBD.

Conditions

• Narcolepsy
• REM Sleep Behavior Disorder

Timeline

• Start date: 2016-01-28
• Primary completion: 2017-12-30
• Completion: 2019-12-30
• First posted: 2017-12-18
• Last updated: 2017-12-18

Locations

1 site across 1 country: China