| Recruiting | Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total NCT07292298 | University of Colorado, Denver | Phase 2 |
| Not Yet Recruiting | Use of a Novel Camera to Check the Bowel After Polyp or Tumour Removal NCT07341126 | University of Edinburgh | — |
| Not Yet Recruiting | ctDNA-Informed Management of Early-Stage Rectal Cancer NCT07209215 | University of California, Davis | Phase 2 |
| Not Yet Recruiting | Advanced Endoscopic Resections for Rectal Neoplasms NCT07410767 | Jagiellonian University | — |
| Not Yet Recruiting | Reporting of Tumour Deposits in Colorectal Cancer by Radiology and Pathology NCT07345273 | Imperial College London | — |
| Not Yet Recruiting | Family Communications After Genetic Testing NCT07143487 | Alliance for Clinical Trials in Oncology | N/A |
| Recruiting | Upfront Trastuzumab-Deruxtecan Plus Capecitabine and Bevacizumab for Patients With HER-2 Positive Metastatic C NCT07407465 | Gruppo Oncologico del Nord-Ovest | Phase 2 |
| Not Yet Recruiting | Involve-site Radiotherapy Combined With Chemotherapy and Immunotherapy as Neoadjuvant Treatment for Locally Ad NCT07161115 | Longhao Li | Phase 2 |
| Recruiting | SCRT Followed by CAPOX + Bev ± PD-1 Inhibitor for TNT in LARC NCT07198165 | Ruijin Hospital | Phase 2 |
| Recruiting | A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Canc NCT06997497 | Merck Sharp & Dohme LLC | Phase 3 |
| Recruiting | FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery NCT06780787 | City of Hope Medical Center | Phase 2 |
| Recruiting | SCRT + mFOLFOX6 + PD-1 Antibody + Targeted Therapy for HIgh-Risk pMMR/MSS Rectal Cancer NCT06908031 | Sixth Affiliated Hospital, Sun Yat-sen University | Phase 2 |
| Not Yet Recruiting | Short-Course Radiotherapy Combined with Intracavitary Brachytherapy Followed by Pucotenlimab, Bevacizumab, Oxa NCT06872606 | Sir Run Run Shaw Hospital | Phase 2 |
| Not Yet Recruiting | A Phase ll Study of Neoadjuvant Short-course Radiotherapy Followed by Ivonescimab and Chemotherapy in pMMR/MSS NCT06919510 | Sun Yat-sen University | Phase 2 |
| Recruiting | Dose Escalated Radiotherapy for Rectal Cancers Using MR-guided Radiotherapy NCT06854679 | Royal Marsden NHS Foundation Trust | N/A |
| Not Yet Recruiting | Efficacy and Safety of Adjunctive Use of Rifaximin In Preventing Radiotherapy-induced Diarrhea in Cancer Patie NCT06783153 | Mansoura University | Phase 1 / Phase 2 |
| Recruiting | Asian Watch-and-Wait Database (AWWD) NCT06631443 | Tata Memorial Centre | — |
| Terminated | First-in-Human Study of ATX-559, an Oral Inhibitor of DHX9, in Patients With Advanced or Metastatic Solid Tumo NCT06625515 | Accent Therapeutics | Phase 1 |
| Recruiting | ProLARS Trial: Prospective Longitudinal Follow-up of Low Anterior Resection Syndrome (LARS) and COREFO Score A NCT07339904 | University Hospital, Antwerp | N/A |
| Not Yet Recruiting | Effect of Pelvic Rehabilitation After Low Anterior Resection for Cancer Rectum. - A Randomised Controlled Tria NCT06524362 | GEM Hospital & Research Center | N/A |
| Recruiting | Trial Utilizing Metronidazole to Optimize the Microbiome of Rectal Adenocarcinoma Undergoing Neoadjuvant Thera NCT06569368 | M.D. Anderson Cancer Center | Phase 2 |
| Recruiting | Nordic ORgan Preservation Pilot Approach Nonrandomised Single-Arm Trial for Non-Operative Management of Rectal NCT06328361 | Tampere University Hospital | N/A |
| Recruiting | A Global, Integrated, Personalized, Stage-related, Multimodal Therapeutic Approach for Rectal Adenocarcinoma B NCT06952101 | Fondazione del Piemonte per l'Oncologia | N/A |
| Recruiting | Active Surveillance and Chemotherapy Before Surgery in Treating Participants With Stage II-III Rectal Cancer NCT03594630 | M.D. Anderson Cancer Center | EARLY_Phase 1 |
| Recruiting | The Efficacy and Safety of Short-course Radiation Combined With Adebrelimab and CAPEOX Neo-adjuvant Therapy fo NCT06266832 | Sir Run Run Shaw Hospital | Phase 2 |
| Completed | Optimization of Adaptive Text Messages for Cancer Survivors (OATS II) NCT05746195 | University of California, San Francisco | N/A |
| Recruiting | Factors Affecting the Results of Treatment of Patients With Colorectal Cancer NCT06050447 | Immanuel Kant Baltic Federal University | — |
| Unknown | Predicting the Efficacy and Prognosis of Rectal Cancer Patients Based on ctDNA-MRD Technology NCT05969938 | WeiWei Xiao | — |
| Recruiting | Evaluating Novel Therapies in ctDNA Positive GI Cancers NCT05482516 | Georgetown University | Phase 3 |
| Recruiting | A Study of Tucatinib and Trastuzumab in People With Rectal Cancer NCT05672524 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Active Not Recruiting | Adaptive Radiation for Locally Advanced Rectal Adenocarcinoma NCT05108428 | H. Lee Moffitt Cancer Center and Research Institute | EARLY_Phase 1 |
| Recruiting | ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation NCT05059444 | Guardant Health, Inc. | — |
| Recruiting | Establishing a ctDNA Biomarker to Improve Organ Preserving Strategies in Patients With Rectal Cancer NCT05081024 | OHSU Knight Cancer Institute | — |
| Withdrawn | Neoadjuvant Therapy for Localized Rectal Adenocarcinoma NCT04418895 | UNC Lineberger Comprehensive Cancer Center | Phase 2 |
| Active Not Recruiting | Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer NCT04963283 | University of Colorado, Denver | Phase 2 |
| Recruiting | MRI-Guided Adaptive Radiation Therapy for Organ Preservation in Rectal Cancer NCT04808323 | Medical College of Wisconsin | Phase 1 |
| Completed | The Safety and Feasibility of MONOFIX on Fascial Closure of Mid-line Wound After Minimally Invasive Colorectal NCT05872334 | Samsung Medical Center | N/A |
| Unknown | Role of Neoadjuvent Radiotherapy in Locally Advanced Cancer Rectum NCT04814784 | Amany sayed Abass | — |
| Terminated | Testing the Addition of a Radiation Sensitizing Drug, IPdR, to the Usual Chemotherapy Treatment (Capecitabine) NCT04406857 | National Cancer Institute (NCI) | Phase 1 |
| Recruiting | Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer NCT04703101 | Jonsson Comprehensive Cancer Center | Phase 1 |
| Unknown | A Trial of Durvalumab (MEDI 4736) in Combination With Extended Neoadjuvant Regimens in Rectal Cancer NCT04621370 | Liz-Anne Lewsley | Phase 2 |
| Recruiting | Monitoring Treatment Response With On-board DWI During Neo-adjuvant Chemo-radiation for Rectal Cancer Using Ma NCT03961776 | Institut Paoli-Calmettes | — |
| Completed | Assessing the Additional Neoplasia Yield of Computer-aided Colonoscopy in a Screening Setting NCT04441580 | Fondazione Poliambulanza Istituto Ospedaliero | N/A |
| Active Not Recruiting | Mechanical Bowel Preparation and Oral Antibiotics Versus Mechanical Bowel Preparation Only Prior Rectal Surger NCT04281667 | Helsinki University Central Hospital | Phase 4 |
| Recruiting | Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors NCT04165772 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Active Not Recruiting | TAS-102 With Concurrent Radiation for the Treatment of Untreated Resectable Stage II-III Rectal Cancer NCT04104139 | OHSU Knight Cancer Institute | Phase 1 |
| Unknown | Optimisation of Radiotherapy in Rectal Cancer (ORREC) NCT04090450 | University of Manchester | — |
| Terminated | Talimogene Laherparepvec, Chemotherapy, and Radiation Therapy Before Surgery in Treating Patients With Locally NCT03300544 | National Cancer Institute (NCI) | Phase 1 |
| Completed | Peptide-based Immunization for Colon- and and Pancreas-carcinoma NCT03871790 | CENTOGENE GmbH Rostock | — |
| Active Not Recruiting | Chimney Trial of Parastomal Hernia Prevention NCT03799939 | University of Oulu | N/A |
| Unknown | Chemo-radiotherapy as Main Treatment Strategy for Rectal Cancer. Can we Provide a More Precise and Effective T NCT03619668 | Aalborg University Hospital | — |
| Terminated | Prestoma-Trial for Parastomal Hernia Prevention NCT03527784 | University of Oulu | N/A |
| Completed | M7824 in Patients With Metastatic Colorectal Cancer or With Advanced Solid Tumors With Microsatellite Instabil NCT03436563 | M.D. Anderson Cancer Center | Phase 1 / Phase 2 |
| Completed | Audit of Surgery for Colorectal Cancer NCT04349384 | Institut National d'Oncologie, Morocco | — |
| Completed | TAS-102 and Radiation Therapy in Treating Patients With Rectal Cancer That Is Locally Recurrent, Metastatic, o NCT03297710 | Mayo Clinic | Phase 1 |
| Completed | S1613, Trastuzumab and Pertuzumab or Cetuximab and Irinotecan Hydrochloride in Treating Patients With Locally NCT03365882 | SWOG Cancer Research Network | Phase 2 |
| Completed | Veliparib, Pembrolizumab, and Combination Chemotherapy in Treating Patient With Locally Advanced Rectal Cancer NCT02921256 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Capecitabine and Lenvatinib With External Radiation in Rectal Adenocarcinoma NCT02935309 | H. Lee Moffitt Cancer Center and Research Institute | Phase 1 |
| Active Not Recruiting | ExIST Study of LY2157299 (Galunisertib) in Rectal Cancer NCT02688712 | Providence Health & Services | Phase 2 |
| Completed | Nintedanib and Capecitabine in Treating Patients With Refractory Metastatic Colorectal Cancer NCT02393755 | Roswell Park Cancer Institute | Phase 1 / Phase 2 |
| Completed | Lower or Standard Dose Regorafenib in Treating Patients With Refractory Metastatic Colorectal Cancer NCT02368886 | Academic and Community Cancer Research United | Phase 2 |
| Terminated | Pelvic Radiotherapy With Concurrent Neoadjuvant FOLFOX for Patients With Newly Diagnosed Rectal Adenocarcinoma NCT02319304 | University of Maryland, Baltimore | Phase 2 |
| Withdrawn | Regorafenib in Reducing Recurrence in Patients With Non-metastatic Rectal Cancer Who Have Completed Curative-I NCT02287727 | Roswell Park Cancer Institute | Phase 2 |
| Terminated | Prospective Validation Study for the Proprietary Rectal and Anal Cancer Protein Expression Assays NCT02407561 | Castle Biosciences Incorporated | — |
| Completed | Phase I Study of Neoadjuvant Radiotherapy With 5-Fluorouracil for Rectal Cancer NCT02270606 | Virginia Commonwealth University | Phase 1 |
| Unknown | Neo-adjuvant Chemoradiotherapy Using Infusional Gemcitabine Followed by Surgery for Locally Advanced Rectal Ca NCT02919878 | King Faisal Specialist Hospital & Research Center | Phase 2 |
| Completed | GRECCAR 8: Primary Tumor Resection in Rectal Cancer With Unresectable Metastasis NCT02314182 | Hospices Civils de Lyon | Phase 3 |
| Terminated | Evaluation of Rectal Cancer Treatment Response Using PET/MRI NCT02233595 | University of California, San Francisco | — |
| Recruiting | Evaluation of Quality of Life and Utilities Following Surgical Treatment of Stage I-IV Rectal Cancer NCT02107105 | M.D. Anderson Cancer Center | — |
| Completed | Immunoscore in Rectal Cancer NCT02017509 | Providence Health & Services | — |
| Terminated | Evaluation of Rectal Tumor Margin Using Confocal Endomicroscopy and Comparison to Histopathology NCT01887509 | IHU Strasbourg | N/A |
| Completed | A Phase I Study of Bavituximab, Capecitabine, and Radiation for the Treatment of Rectal Adenocarcinoma NCT01634685 | University of Texas Southwestern Medical Center | Phase 1 |
| Active Not Recruiting | Young-Onset Colorectal Cancer NCT02863107 | M.D. Anderson Cancer Center | — |
| Completed | Neoadjuvant Chemoradiation With Bevacizumab for Chinese Rectal Cancer Patients NCT01554059 | Sixth Affiliated Hospital, Sun Yat-sen University | Phase 2 |
| Completed | Interest of Saline MR Peritoneography for Pre-operative Assessment of Rectal Cancer NCT01497457 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | N/A |
| Unknown | Extralevator Versus Standard Abdominoperineal Resection For Rectal Adenocarcinoma NCT01702116 | Stony Brook University | N/A |
| Terminated | Prospective Pilot Study of Multimodal Radiological Evaluation Feasibility During Chemoradiotherapy of Rectal A NCT01619696 | University Hospital, Toulouse | Phase 2 |
| Completed | Proteomic Approach Using Matrix-assisted Laser Desorption/Ionization Tandem Time-of-flight (MALDI-TOF/TOF) of NCT00855946 | University Hospital, Bordeaux | — |
| Completed | Bevacizumab, Radiation Therapy, and Combination Chemotherapy in Treating Patients Who Are Undergoing Surgery f NCT00321685 | National Cancer Institute (NCI) | Phase 2 |
| Unknown | Avoiding Surgery in Rectal Cancer After Pre-Operative Therapy NCT01047969 | Royal Marsden NHS Foundation Trust | Phase 2 |
| Completed | Factors Predicting Recurrence in Rectal Cancer After Surgery NCT03899870 | ammar houssem | — |
| Withdrawn | Pan FGFR Kinase Inhibitor BGJ398 and Combination Chemotherapy in Treating Patients With Untreated Metastatic P NCT02575508 | Roswell Park Cancer Institute | Phase 1 / Phase 2 |