| Not Yet Recruiting | Comparison of Post-Dural Puncture Headache After Spinal Anesthesia Using Median Versus Paramedian Approach NCT07436403 | Mayo Hospital Lahore | N/A |
| Not Yet Recruiting | Optic Nerve Sheath Diameter for Predicting Post-Dural Puncture Headache in Cesarean Section Patients NCT07497945 | Kocaeli University | — |
| Recruiting | Efficacy of Sphenopalatine Block Compared to Blood Patch in the Management of Post-dural Puncture Headaches NCT07354464 | University Hospital, Clermont-Ferrand | Phase 3 |
| Completed | Optic Nerve Sheath Diameter in Postspinal Headache NCT06957899 | Konya City Hospital | — |
| Recruiting | Evaluation of Post-dural Puncture Headache in Female Patients Undergoing Obstetric and Non-obstetric Surgery NCT06992063 | Duzce University | — |
| Not Yet Recruiting | Comparison of Nebulized Neostigmine/Atropine Versus Lignocaine in Treating Acute Post-dural Puncture Headache NCT06824025 | Minia University | EARLY_Phase 1 |
| Not Yet Recruiting | Prophylactic Intravenous Injection of Neostigmine Plus Atropine Versus Ketorolac on Post-dural Puncture Headac NCT06729047 | Assiut University | Phase 1 / Phase 2 |
| Recruiting | Theophylline, Versus Sumatriptan and Gabapentin in The Treatment of Post-Dural Puncture Headache NCT07515456 | Tanta University | N/A |
| Completed | Sphenopalatine Ganglion Block for Post-Dural Puncture Headache NCT07494383 | ISSSTE Hospital Regional "Gral. Ignacio Zaragoza" | N/A |
| Not Yet Recruiting | Intrathecal Catheter Placement Versus Resiting Epidural Catheter After Dural Puncture in Obstetric Patients NCT05977361 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Unknown | Comparison of the Effect of Aminophylline, Magnesium Sulphate and Placebo in Prevention of Post Dural Puncture NCT06272916 | Assiut University | — |
| Recruiting | Pathophysiological Mechanisms and Implication of Treatment in Postural Puncture Headache NCT06253754 | Umeå University | — |
| Recruiting | Contribution of Ondansetron to Preventing Post-Dural Puncture Headaches Following Spinal Anesthesia NCT06444737 | Mongi Slim Hospital | N/A |
| Completed | Nebulized Dexmedetomidine Versus Oral Sumatriptan in Treatment of Post Dural Puncture Headache in Cesarean Sec NCT06514040 | Fayoum University Hospital | N/A |
| Completed | Effect of Nebulized Dexmedetomidine on Post-dural Puncture Headache NCT06470854 | Tanta University | N/A |
| Completed | Comparison of Acetaminophen With Aminophylline and Aminophylline With Dexamethasone for Prophylaxis of PDPH in NCT07528118 | Sargodha Medical College | Phase 2 |
| Active Not Recruiting | Factors Associated With the Onset of Chronic Headaches in Patients Who Received a Blood Patch in Post Partum NCT05888324 | Assistance Publique - Hôpitaux de Paris | — |
| Recruiting | Effect of Altitude on Postdural Puncture Headache After Caesarean Delivery NCT05804448 | B.P. Koirala Institute of Health Sciences | — |
| Unknown | Trans-nasal Sphenopalatine Ganglion Block Versus Ultrasound-guided Bilateral Greater and Lesser Occipital Nerv NCT06705244 | Ain Shams University | N/A |
| Unknown | Effects of MET on PPDH, Neck Pain and Disability After Cesarean Section NCT05834140 | Riphah International University | N/A |
| Unknown | Different Approaches of Spinal Anesthesia in Patients Undergoing Cesarean Section NCT05637645 | Bahawal Victoria Hospital Bahawalpur | N/A |
| Completed | Effect of Intrathecal Neostigmine on Post-dural Puncture Headache. NCT05289323 | Alexandria University | Phase 4 |
| Completed | Effects of Preoperative Coffee Consumption in Cesarean Sections Under Spinal Anesthesia NCT05262933 | TC Erciyes University | — |
| Unknown | Sphenopalatine Block Versus Greater Occipital Nerve Block in PDPH NCT05235256 | Ain Shams University | N/A |
| Completed | The Effect of Ganglion Sphenopalatine Block (GSP-block) Follow-Up NCT05301387 | University Hospital Bispebjerg and Frederiksberg | — |
| Recruiting | Neostigmine and Glycopyrrolate for the Treatment of Headache After Dural Puncture NCT05116930 | Mayo Clinic | Phase 2 |
| Unknown | Comparing the Effects of Ondansetron Versus Dexamethasone on the Incidence of Post-dural Puncture Headache (PD NCT05202574 | Minia University | Phase 2 |
| Completed | Bilateral Sphenopalatine Ganglion Block With or Without Bilateral Greater Occipital Nerve Block for Treatment NCT04844229 | Zagazig University | N/A |
| Completed | A Study to Test Performance of Needle Placements for Neuraxial Procedures Using Tactile Imaging vs Control NCT04796935 | IntuiTap Medical, Inc | N/A |
| Completed | Sphenopalatine Ganglion Block for Management of Post- Dural Puncture Headache in Obstetric Patients NCT04793490 | Ain Shams University | N/A |
| Completed | Long-term Complications of Unintentional Dural Puncture During Labour Epidurals and Epidural Blood Patch. NCT04696627 | Samuel Lunenfeld Research Institute, Mount Sinai Hospital | — |
| Unknown | Sphenopalatine Ganglion Block for Post-Dural Puncture Headache in Orthopedic Patients NCT04657952 | Tanta University | Phase 4 |
| Completed | SGB in Management of Patients With PDPH Using TCD NCT04401878 | Zagazig University | N/A |
| Completed | Effectiveness of Nebulized Dexmedetomidine for Treatment of Obstetric Post-Dural Puncture Headache NCT04327726 | Zagazig University | N/A |
| Completed | Is Theophylline More Effective Than Sumatriptan in the Treatment of Post-dural Puncture Headache NCT04257851 | Damanhour Teaching Hospital | Phase 4 |
| Completed | Association Between Chronic Headache and Back Pain With Childbirth NCT04091321 | Stanford University | — |
| Terminated | Effectiveness of Sphenopalatine Ganglion Block for Post-Dural Puncture Headache NCT03430531 | Milton S. Hershey Medical Center | Phase 2 |
| Completed | Pregabalin Versus Hydrocortisone for Postdural Puncture Headache After Spinal for Cesarean NCT03910088 | Cairo University | Phase 4 |
| Completed | Is Aminophylline More Effective Than Neostigmine/Atropine Mixture in the Treatment of Post-dural Puncture Head NCT03997006 | Damanhour Teaching Hospital | Phase 4 |
| Completed | Intrathecal Neostigmine for Prevention of PDPH NCT03587441 | Fayoum University Hospital | Phase 4 |
| Withdrawn | RCT of SPG Blocks for Post-dural Headache NCT03560349 | University of Utah | Phase 2 |
| Completed | Long Term Outcomes Following a Post Dural Puncture Headache NCT03550586 | Rabin Medical Center | — |
| Completed | Two Fluid Strategies for Prevention of Post-dural Puncture Headache NCT03475784 | Cairo University | Phase 3 |
| Unknown | The Sphenopalatine Ganglion Block for Post-dural Puncture Headache NCT03385772 | Brigham and Women's Hospital | N/A |
| Completed | Different Approaches for the Management of Post-dural Puncture Headache NCT05253014 | Bahaa Mohammed Refaie | N/A |
| Completed | Long Term Outcomes After Accidental Dural Puncture ADP Study NCT03080779 | University Hospitals, Leicester | — |
| Completed | Non-Luer Butterfly Needle With One-way Valve for the Epidural Blood Patch: Does it Alter Blood Clotting? NCT03420352 | University Hospitals, Leicester | N/A |
| Terminated | Sphenopalatine Block or Epidural Bloodpatch for Post Dural Puncture Headache: Randomized Controlled Trial NCT02984618 | Brasilia University Hospital | N/A |
| Terminated | Evaluation of the Effectiveness and Tolerance of Tetracosactide Synacthen® in the Treatment of Post Dural Punc NCT02813655 | Hospices Civils de Lyon | Phase 2 |
| Terminated | The Influence of Needle Diameter on Post Dural Puncture Headache NCT02827058 | Helse Nord-Trøndelag HF | N/A |
| Completed | EPiMAP Obstetrics: European Practices in the Management of Accidental Dural Puncture in Obstetrics NCT02362828 | European Society of Anaesthesiology | — |
| Terminated | Maintaining a Prone Position After Use of an Epidural Blood Patch for the Treatment of Post-dural Puncture Hea NCT02427009 | Centre Hospitalier Universitaire de Nīmes | N/A |
| Completed | Aminophylline for Patients With Post-Dural Puncture Headache NCT02522013 | The First Affiliated Hospital of Zhengzhou University | Phase 3 |
| Completed | Long-term Effects of Accidental Dural Puncture in Patients Having Had an Epidural Blood Patch (LEAP) NCT02149680 | Örebro University, Sweden | — |
| Completed | Post-dural Puncture Headache - Needles and Biomarkers in CSF NCT02384031 | Nordlandssykehuset HF | N/A |
| Unknown | Bedside Sedation for the Prevention of Post Dural Puncture Headache NCT01503788 | Tel-Aviv Sourasky Medical Center | Phase 2 |
| Withdrawn | Post Dural Puncture Headache After Accidental Dural Puncture NCT01448590 | Sunnybrook Health Sciences Centre | — |
| Completed | Effect of Small Versus Large Epidural Needles on Postdural Puncture Headache Study NCT00370604 | Sunnybrook Health Sciences Centre | N/A |
| Withdrawn | Caffeine Versus Placebo for Spinal Headaches NCT00809627 | United States Naval Medical Center, Portsmouth | N/A |
| Completed | The Occurrence of Post Dural Puncture Headache After Epidural Blood Patch NCT03080610 | Siriraj Hospital | — |