NCT04257851

Is Theophylline More Effective Than Sumatriptan in the Treatment of Post-dural Puncture Headache

Is Theophylline More Effective Than Sumatriptan in the Treatment of Post-dural Puncture Headache: A Randomized Clinical Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Damanhour Teaching Hospital · Other Government
• Sex: All
• Age: 21 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Objectives: To compare the safety and efficacy of oral theophylline versus oral sumatriptan in the treatment of post-dural puncture headache (PDPH). Background: PDPH is the most frequent complication of procedures associated with dural puncture for spinal anesthesia or following accidental dural puncture during epidural anesthesia. Since invasive treatments have known complications, pharmacologic management may be preferable. Patients and Methods: This was a prospective, randomized, double-blind, phase four clinical trial; carried out on 60 patients presented with PDPH at our hospital. Patients were randomly allocated into two equal groups (30 patients each); group T, received oral theophylline, and group S, received oral sumatriptan.

Conditions

• Post-Dural Puncture Headache

Interventions

Type	Name	Description
DRUG	Theophylline Anhydrous Oral Tablet	Theophylline tablet (150 mg/12h)
DRUG	Sumatriptan Succinate Oral Tablet	Sumatriptan tablet (25 mg/12h)

Timeline

• Start date: 2020-02-15
• Primary completion: 2021-05-15
• Completion: 2021-05-15
• First posted: 2020-02-06
• Last updated: 2021-06-03

Locations

1 site across 1 country: Egypt