| Recruiting | Serological Testing and Treatment for Plasmodium Vivax Malaria: a Trial in Ethiopia and Madagascar NCT06923592 | London School of Hygiene and Tropical Medicine | Phase 3 |
| Active Not Recruiting | Targeted Antimalarial Drug Administration for Seasonal Migrant Populations in Amhara Region, Ethiopia NCT06516042 | PATH | Phase 3 |
| Completed | Clinical Practices for Treating Severe Malaria Caused by P. Falciparum NCT07027722 | Centre Hospitalier de Saint-Denis | — |
| Terminated | A Study of the Plasmodium Falciparum Malaria Vaccine Candidate Pfs48/45 in Matrix-M Adjuvant in the UK NCT05400746 | University of Oxford | EARLY_Phase 1 |
| Completed | Efficacy of Artesunate-amodiaquine and Artemether-lumefantrine for Treatment of Plasmodium Falciparum Malaria NCT06300970 | Centers for Disease Control and Prevention | Phase 4 |
| Completed | A Study of Blood-stage Controlled Human Plasmodium Falciparum Malaria Infection in Tanzania NCT04788862 | University of Oxford | N/A |
| Completed | Study of Malaria Vaccine RTS,S/AS01E in Plasmodium Falciparum-infected and Uninfected Adults Pre-treated With NCT04661579 | PATH | Phase 2 |
| Terminated | The Malaria Heart Disease Study NCT04445103 | University Hospital, Gentofte, Copenhagen | — |
| Withdrawn | A Clinical Trial to Evaluate Plasmodium Falciparum 7G8 and NF54 Challenge Strains (PfSPZ) in a Head-to-head Co NCT04203186 | U.S. Army Medical Research and Development Command | N/A |
| Completed | Comparison of Arterolane-piperaquine Versus Arterolane-piperaquine+Mefloquine Versus Artemether-lumefantrine i NCT03452475 | University of Oxford | Phase 3 |
| Completed | Clinical Performance of the HRP2 HS-RDT for Malaria Diagnosis in Pregnant Women NCT03172221 | Foundation for Innovative New Diagnostics, Switzerland | — |
| Completed | ELISA Validation of Hypersensitive Rapid Diagnostic Test Results for Detection of P. Falciparum NCT03132402 | University of Oxford | — |
| Completed | Safety and Protective Efficacy of Pb(PfCS@UIS4) NCT03138096 | Radboud University Medical Center | Phase 1 / Phase 2 |
| Completed | Prevalence Survey of Plasmodium Falciparum Antimalarial Drug Resistance Markers NCT02895568 | University of Oxford | — |
| Completed | Safety and Protective Efficacy of BCG Vaccination Against Controlled Human Malaria Infection NCT02692963 | Radboud University Medical Center | Phase 2 |
| Completed | Safety and Immunogenicity of Direct Venous Inoculation of a Radiation-attenuated PfSPZ Vaccine in Equatoguinea NCT02418962 | Sanaria Inc. | Phase 1 |
| Completed | Dihydroartemisinin-piperaquine With Low Dose Primaquine to Reduce Malaria Transmission NCT02259426 | London School of Hygiene and Tropical Medicine | Phase 3 |
| Completed | A Phase Ia Clinical Trial to Assess the Safety and Immunogenicity of New Plasmodium Falciparum Malaria Vaccine NCT02181088 | University of Oxford | Phase 1 |
| Completed | Efficacy and Safety of a Single Low-dose Primaquine for the Clearance of Gametocytes NCT02090036 | Muhimbili University of Health and Allied Sciences | Phase 4 |
| Completed | Safety, Tolerability, Pharmacokinetics and Efficacy of ARCO NCT01930331 | Ifakara Health Institute | Phase 4 |
| Completed | Low Dose Primaquine for Clearance of Gametocytes NCT01935882 | London School of Hygiene and Tropical Medicine | Phase 2 / Phase 3 |
| Completed | Plasmodium Falciparum Artemisinin Resistance Vietnam NCT01775592 | National Institute of Malariology, Parasitology and Entomology, Vietnam | Phase 4 |
| Completed | Controlled Human Malaria Infection (CHMI) After Immunization With Cryopreserved Plasmodium Falciparum Sporozoi NCT01728701 | Sanaria Inc. | Phase 1 |
| Completed | Immunization With Plasmodium Falciparum Sporozoites Under Chloroquine Versus Mefloquine Prophylaxis NCT01422954 | Radboud University Medical Center | N/A |
| Completed | Optimisation of Controlled Human Malaria Infection Using Sporozoites Administered by Needle and Syringe NCT01465048 | University of Oxford | N/A |
| Completed | Pilot Study to Estimate the Burden and Distribution of Plasmodium Falciparum Malaria in Kalifabougou, Mali in NCT01160562 | National Institute of Allergy and Infectious Diseases (NIAID) | — |
| Completed | Comparison of Three Plasmodium Falciparum Isolates in an Experimental Human Malaria Infection NCT01002833 | Radboud University Medical Center | N/A |
| Completed | Effect of Bednets and a Water Purification Device on HIV Disease Progression Among ART naïve Patients in Kenya NCT00914225 | University of Washington | — |
| Completed | Clinical Trial of the PfSPZ Vaccine NCT01001650 | Sanaria Inc. | Phase 1 |
| Completed | NMRC-M3V-Ad-PfCA Vaccine - Clinical Trial 1 NCT00392015 | U.S. Army Medical Research and Development Command | Phase 1 / Phase 2 |
| Completed | Antimalarial Treatments for Clearing Low Density P. Falciparum and Its Impact on Malaria Transmission NCT00646126 | Tropical Medicine Research Institute | Phase 3 |
| Completed | Safety, Immunogenicity of RTS,S/AS02A, and RTS,S/AS01B Malaria Vaccines in Malaria-experienced Adults. NCT00197054 | U.S. Army Medical Research and Development Command | Phase 2 |
| Completed | PpPfs25/ISA51 and ScPvs25/ISA51 Vaccines for Malaria NCT00295581 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 1 |