NCT01775592

Plasmodium Falciparum Artemisinin Resistance Vietnam

Monitoring the Efficacy of Dihydroartemisinin - Piperaquine in Patients With Uncomplicated Falciparum Malaria in Traleng Commune, Central Vietnam

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 95 (actual)
• Sponsor: National Institute of Malariology, Parasitology and Entomology, Vietnam · Other Government
• Sex: All
• Age: 2 Months
• Healthy volunteers: Not accepted

Summary

Resistance of Plasmodium falciparum toward Artemisinins, the most important drug for the successful treatment of malaria, has been confirmed in Cambodia. There are few reports from neighbouring countries about delayed parasite rates. The investigators therefore aim to assess parasite clearance in malaria patients in central Vietnam when treated according to national standard guidelines.

Detailed description

General objective To evaluate the efficacy of DHA-PPQ in patients with uncomplicated falciparum malaria in a rural area of Central Vietnam, and to assess the in vitro susceptibility of P.falciparum isolates to DHA and PPQ. Specific objectives 1. To measure the parasite clearance time in falciparum malaria patients treated with DHA-PPQ. 2. To determine the efficacy of DHA-PPQ at day 42 post-treatment. 3. To assess the in vitro susceptibility of P.falciparum isolates towards DHA and PPQ in Quang Nam Province. 4. To compare genetic profiles of P.falciparum isolates with delayed and those with normal clearance times in order to identify potential markers of resistance;

Conditions

• Plasmodium Falciparum

Interventions

Type	Name	Description
DRUG	Arterakin (DHA-PPQ)

Timeline

• Start date: 2012-09-01
• Primary completion: 2013-01-01
• Completion: 2013-01-01
• First posted: 2013-01-25
• Last updated: 2013-01-28

Locations

1 site across 1 country: Vietnam