| Withdrawn | Cell-Based Therapy for White Matter Repair in Periventricular Leukomalacia NCT06985303 | MGAM LLC | EARLY_Phase 1 |
| Recruiting | Genetics of Neonatal Encephalopathy and Related Disorders NCT07165938 | Boston Children's Hospital | — |
| Not Yet Recruiting | Nephroprotection Following Perinatal Asphyxia: Randomized Controlled Trial NCT07088328 | Alexandria University | N/A |
| Not Yet Recruiting | Dexmedetomidine Versus Morphine During Cooling Therapy in Neonates NCT06985290 | Ipsita Goswami | Phase 2 |
| Recruiting | Intranasal Breast Milk Therapy in HIE NCT06746532 | Semmelweis University | EARLY_Phase 1 |
| Recruiting | Feasibility and Safety of Intranasally Administered Breast Milk in HIE NCT06747260 | Semmelweis University | EARLY_Phase 1 |
| Withdrawn | Remote EEG Device for Identification of Risk for Neonatal Seizures NCT05239585 | Mayo Clinic | N/A |
| Recruiting | Treatment of Neonatal Encephalopathy With Oral Sildenafil Suspension to Repair Brain Injury Secondary to Birth NCT06098833 | Pia Wintermark | Phase 2 |
| Recruiting | Cooling in Mild Encephalopathy NCT05889507 | Imperial College London | Phase 3 |
| Active Not Recruiting | Assessment of Diastolic Function During the Transitional Period and Infancy Using Serial Echocardiography NCT06200519 | University College Cork | — |
| Not Yet Recruiting | The Long-term Consequences of Neonatal Encephalopathy in the Hypothermia Era NCT05756296 | McGill University Health Centre/Research Institute of the McGill University Health Centre | — |
| Recruiting | Assess Safety and Efficacy of Sovateltide in Hypoxic-ischemic Encephalopathy NCT05514340 | Pharmazz, Inc. | Phase 2 |
| Active Not Recruiting | Investigating Cerebral Oxygenation in the Newborn NCT05588960 | University of Edinburgh | — |
| Completed | Neonatal Electrical Activity at Different Altitude Levels NCT05966714 | Children's Hospital of Fudan University | — |
| Recruiting | Natural History Study of Patients with HPDL Mutations NCT05848271 | University of California, San Diego | — |
| Recruiting | A Dose Escalation Study of Levetiracetam in the Treatment of Neonatal Seizures NCT05610085 | University of California, San Diego | Phase 2 |
| Completed | Enteral Feeding and Splanchnic NIRS Values in Infants With Neonatal Encephalopathy (NE) NCT05471336 | NYU Langone Health | N/A |
| Completed | Passive Cooling Versus Blanket-Roll III on The Myocardial Function of Asphyxiated Neonates NCT05652738 | Alexandria University | N/A |
| Completed | Telemedicine to Reduce Disparities in the Identification and Treatment of Neonatal Encephalopathy NCT05155111 | MaineHealth | N/A |
| Unknown | Neonatal Neurological Examination to Detect Infants at Risk NCT05772416 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Unknown | Darbepoetin in Neonatal Encephalopathy Trial NCT04432662 | Imperial College London | Phase 2 |
| Unknown | Neonate Cerebral Activity in Immediate Post Partum NCT04225975 | Centre Hospitalier Universitaire, Amiens | N/A |
| Unknown | Follow-up of Inflammatory Responses and Multiorgan Outcomes FoLlowing Neonatal Brain injurY NCT04816331 | University of Dublin, Trinity College | — |
| Unknown | TIME Study: Therapeutic Hypothermia for Infants With Mild Encephalopathy NCT04176471 | Stanford University | N/A |
| Unknown | Prevention of Epilepsy by Reducing Neonatal Encephalopathy NCT04054453 | Thayyil, Sudhin | N/A |
| Recruiting | Healthy Little Eyes NCT05971446 | University of Wisconsin, Madison | — |
| Unknown | Optimising the Duration of Cooling in Mild Encephalopathy NCT03409770 | Thayyil, Sudhin | N/A |
| Unknown | Evaluating the NeoTree in Malawi and Zimbabwe NCT05127070 | University College, London | — |
| Active Not Recruiting | Transcutaneous Carbon Dioxide Monitoring in Neonates Receiving Therapeutic Hypothermia for Neonatal Encephalop NCT04603547 | Brigham and Women's Hospital | — |
| Unknown | Inflammation and Metabolic Acidosis at Birth (AGAIN: AutophaGy AcIdosis Newborn) NCT03897101 | University Hospital of Ferrara | — |
| Completed | The Impact of Holding on Stress and Bonding in Mother-Infant Pairs During Therapeutic Hypothermia NCT03837717 | MaineHealth | N/A |
| Unknown | Video-Debriefing for Improved Competence Among Skilled Birth Attendants in Lira District-Northern Uganda NCT03703622 | Makerere University | N/A |
| Completed | Telemedicine to Improve Use of Therapeutic Hypothermia in Rural Settings NCT03706417 | MaineHealth | N/A |
| Completed | Mild Encephalopathy in the Newborn Treated With Darbepoetin NCT03071861 | University of New Mexico | Phase 2 |
| Completed | OMT to Improve Feeding After Hypothermia NCT03380013 | MaineHealth | N/A |
| Unknown | Heart Beat Variability in Neonatal Encephalopathy NCT03179553 | Imperial College London | — |
| Completed | Pacifier Activated Device and Mother's Voice in Infants at High-risk for Cerebral Palsy NCT03230032 | Nationwide Children's Hospital | N/A |
| Completed | High-dose Erythropoietin for Asphyxia and Encephalopathy NCT02811263 | University of California, San Francisco | Phase 3 |
| Completed | Uterine Activity in Moderate-Severe Neonatal Encephalopathy: A Case Control Study NCT03122808 | The Rotunda Hospital | — |
| Completed | Sildenafil Administration to Treat Neonatal Encephalopathy NCT02812433 | McGill University Health Centre/Research Institute of the McGill University Health Centre | Phase 1 |
| Recruiting | Neonatal Neurologic Intensive Care Network of China NCT02544100 | Children's Hospital of Fudan University | — |
| Completed | Hypothermia for Encephalopathy in Low and Middle-Income Countries Trial NCT02387385 | Thayyil, Sudhin | N/A |
| Recruiting | Perinatal Brain Injury: Potential of Innovative NIRS to Optimize Hypothermia NCT02793999 | Boston Children's Hospital | — |
| Completed | Autologous Cord Blood Cell Therapy for Neonatal Encephalopathy NCT02256618 | Neonatal Encephalopathy Consortium, Japan | Phase 1 |
| Completed | Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes in Newborn Brain Injury (NEATO) NCT01913340 | University of California, San Francisco | Phase 1 / Phase 2 |
| Completed | Hypothermia for Encephalopathy in Low Income Countries-Feasibilty NCT01760629 | Thayyil, Sudhin | N/A |
| Completed | Magnetic Resonance Biomarkers in Neonatal Encephalopathy NCT01309711 | Imperial College London | — |
| Completed | CoolCap Followup Study-Coordination of Participating Centers NCT00581581 | University of Rochester | — |