NCT07165938

Genetics of Neonatal Encephalopathy and Related Disorders

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: Boston Children's Hospital · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Investigators at Boston Children's Hospital are conducting research in order to better understand the genetic factors which may contribute to neonatal encephalopathy (NE) and related disorders. These findings may help explain the broad spectrum of clinical features and outcomes seen in individuals with a history of NE.

Detailed description

Neonatal encephalopathy (NE) is a disorder of term newborns involving dysfunction of the central nervous system and can impact one's health throughout the lifespan. While NE can be caused by a number of exposures or external factors, in some cases there is no cause identified or the severity of the condition cannot fully be explained by external factors. In these cases, there is increasing evidence to suggest underlying genetic factors may contribute to NE. The investigators' research effort is focused on identifying genetic changes (known as "DNA variants") that cause or contribute to NE. By doing so the investigators hope to improve diagnosis and management of NE. We have two specific aims: Aim 1: To identify genetic causes of and contributors to NE and related disorders. Aim 2: To correlate genetic findings with clinical features.

Conditions

• Neonatal Encephalopathy
• Hypoxic Ischaemic Encephalopathy (HIE)

Timeline

• Start date: 2026-02-04
• Primary completion: 2035-09-01
• Completion: 2035-09-01
• First posted: 2025-09-10
• Last updated: 2026-03-11

Locations

1 site across 1 country: United States