| Active Not Recruiting | Dalargin for Prevention of Organ Disfunction in High-Risk Abdominal Surgery NCT07404358 | Botkin Hospital | Phase 3 |
| Active Not Recruiting | Actualities in Procedural Sedation: Remimazolam NCT07362173 | Iuliu Hatieganu University of Medicine and Pharmacy | Phase 4 |
| Not Yet Recruiting | Polish Nationwide Register of Hospitalized Patients in Cardiac Intensive Care Units NCT06371677 | Medical University of Warsaw | — |
| Recruiting | Feasibility Pilot Study to Evaluate the Safety and Performance of the MEX-CD1 Medical Device in ACLF NCT06340269 | Mexbrain | N/A |
| Completed | Incidence of Acute Kidney Injury and Risk Factors in Newborns With Congenital Diaphragmatic Hernia NCT06050525 | Karolinska Institutet | — |
| Unknown | Evaluation of the Effectiveness of Extracorporeal Methods for Removing Mediators of Systemic Inflammation NCT05182723 | Petrovsky National Research Centre of Surgery | N/A |
| Unknown | Feasibility Study of MicroKine Dx System in Critically-ill Pediatric Patients. NCT04295278 | PreDxion Bio, Inc. | — |
| Unknown | Innovative Technologies for the Treatment of Pulmonary and Heart Failure NCT05090930 | National Research Center for Cardiac Surgery, Kazakhstan | N/A |
| Unknown | Observational Trial on Cytokine Adsorption in Sepsis NCT04306419 | RWTH Aachen University | — |
| Not Yet Recruiting | Exosome of Mesenchymal Stem Cells for Multiple Organ Dysfuntion Syndrome After Surgical Repaire of Acute Type NCT04356300 | Fujian Medical University | N/A |
| Recruiting | Impact of Metabolite Supplementation to Restore Mitochondrial Dysfunction During Septic Shock: a Preclinical S NCT04288635 | University Hospital, Angers | — |
| Completed | Clinical Use of Stem Cells for the Treatment of Covid-19 NCT04392778 | SBÜ Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi | Phase 1 / Phase 2 |
| Unknown | Early Haemadsorption in Major Burns NCT04195126 | University of Pecs | N/A |
| Recruiting | Burden, Mortality and Supply Costs in Intensive Care Unit Patients NCT04094428 | University of Ulm | — |
| Terminated | Early Metabolic Resuscitation for Septic Shock NCT03895853 | M.D. Anderson Cancer Center | Phase 2 |
| Unknown | The Blood Pressure Analysis on Critically Ill Patients NCT03827369 | Taoyuan General Hospital | — |
| Completed | Facilitating Communication Study NCT03721952 | University of Washington | N/A |
| Withdrawn | Efficacy of Coenzyme Q10 Supplementation on Multi-Organ Dysfunction in Severely Burned Patients NCT03968640 | American Burn Association | Phase 3 |
| Completed | Benefit of Clarithromycin in Patients With Severe Infections Through Modulation of the Immune System NCT03345992 | Hellenic Institute for the Study of Sepsis | Phase 3 |
| Unknown | Dynamic Monitoring of Circulating microRNA Changes in Patients With or Without Multiple Organ Failure NCT03059524 | University of Electronic Science and Technology of China | — |
| Completed | Trial of Enteral Glutamine on Clinical Outcomes in Critically Ill Patients NCT02998931 | Shahid Beheshti University | Phase 3 |
| Unknown | TPE in Septic Patients and Influence on Organ Failure NCT02906345 | University of Rostock | N/A |
| Unknown | Timing of Acute Palliative Care Consultation in Critically Ill Patients NCT02858778 | Wayne State University | N/A |
| Completed | Impact of Human Blood Serum From Critically Ill Patients on Human Colon Neuronal Networks. NCT02706314 | University of Rostock | — |
| Unknown | The Pharmacokinetics of Fentanyl in Intensive Care Patients NCT02587273 | Oslo University Hospital | Phase 4 |
| Completed | Prevention of Severe Acute Respiratory Failure in Patients With PROOFCheck NCT02488174 | Albert Einstein College of Medicine | N/A |
| Completed | Intestinal-Specific Organ Function Assessment (iSOFA Study) NCT02613000 | University of Tartu | — |
| Unknown | Microcirculatory Alteration and Biomarkers: New Approach for Early Assessment of Septic Multi-organ Dysfunctio NCT02426645 | Prof. Dr. Marc-H. Dahlke, Ph. D. | — |
| Completed | Pharmacokinetics of Two Different High-dose Regimens of Intravenous Vitamin C in Critically Ill Patients NCT02455180 | Amsterdam UMC, location VUmc | Phase 4 |
| Unknown | Use of Extracorporeal Treatment With the Cytosorb-Adsorber for the Reduction of SIRS in Heart Surgery Patients NCT02265419 | University of Rostock | N/A |
| Unknown | Using Human Menstrual Blood Cells to Treat Acute Lung Injury Caused by H7N9 Bird Flu Virus Infection NCT02095444 | S-Evans Biosciences Co., Ltd. | Phase 1 / Phase 2 |
| Completed | Supplemental Parenteral Nutrition in Critically Ill Adults: A Pilot Randomised Controlled Trial NCT01847534 | Australian and New Zealand Intensive Care Research Centre | Phase 2 / Phase 3 |
| Completed | A Validation of a Genomics Based Prognostic in Severe Trauma NCT01810328 | University of Florida | N/A |
| Completed | LDH as a Biochemical Biomarker to Predict Organ Failure in the Emergency Department Setting NCT01937676 | Karolinska Institutet | — |
| Unknown | Application of Biomarkers Change to Predict Outcome of Patient With Severe Sepsis NCT02871895 | Chang Gung Memorial Hospital | — |
| Unknown | Application of Stimulated Immune Response Change to Predict Outcome of Patient With Severe Sepsis NCT02887274 | Chang Gung Memorial Hospital | — |
| Unknown | Quantification of Drugs and Their Degradation Products NCT01828372 | University of Cologne | N/A |
| Completed | TCF7L2 Polymorphisms Influence on Glycemic Control in ICU Patients With Organ Failure NCT03055169 | University Hospital, Lille | — |
| Unknown | Autologous Stem Cells in Newborns With Oxygen Deprivation NCT01506258 | Hospital Universitario Dr. Jose E. Gonzalez | N/A |
| Unknown | Severe Sepsis/Septic Shock on Admission to the General Surgical ICU NCT01363635 | Mahidol University | — |
| Unknown | L-citrulline Supplementation During Sepsis NCT00628381 | Maastricht University Medical Center | Phase 3 |
| Completed | The Value of PSP in Predicting Outcome in ICU Surgical Peritonitis Patients NCT01465711 | University of Magdeburg | — |
| Completed | Nadroparin Anticoagulation for Continuous Venovenous Hemofiltration NCT00965328 | Onze Lieve Vrouwe Gasthuis | Phase 4 |
| Unknown | Effect of Rosiglitazone on ADMA in Critical Illness NCT00409097 | Amsterdam UMC, location VUmc | Phase 3 |
| Completed | The Procalcitonin and Survival Study NCT00271752 | Danish Procalcitonin Study Group | N/A |
| Completed | Intrapleural Methylprednisolone Injection for Multiple Organ Failure With Acute Respiratory Distress Syndrome NCT01423864 | National Taiwan University Hospital | Phase 2 |
| Completed | Patient Plasma Response and Outcome in Septic Shock With Thrombocytopenia Associated Multiple Organ Failure in NCT00118664 | Children's Healthcare of Atlanta | — |
| Completed | Trial of Glutamine and Antioxidant Supplementation in Critically Ill Patients NCT00133978 | Daren K. Heyland | N/A |
| Completed | Inflammation and the Host Response to Injury (Burns) NCT00257244 | Massachusetts General Hospital | — |
| Completed | Inflammation and the Host Response to Injury (Trauma) NCT00257231 | Massachusetts General Hospital | — |
| Suspended | Albumindialysis in Acute Pancreatitis NCT00483912 | Tampere University | N/A |