NCT05182723

Evaluation of the Effectiveness of Extracorporeal Methods for Removing Mediators of Systemic Inflammation

Evaluation of the Effectiveness of Extracorporeal Methods for Removing Mediators of Systemic Inflammation in Patient With Multiple Organ Dysfunction Syndrome After Heart and Aortic Surgery

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Petrovsky National Research Centre of Surgery · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to assess the effectiveness and the safety of extracorporeal methods for removing mediators of systemic inflammation in patients with multiple organ dysfunction syndrome after heart and aorta surgery.

Detailed description

After being informed about the study and potential risk, all patients with multiple organ dysfunction syndrome after heart and aorta surgery with indications for extracorporeal removal of inflammatory mediators, giving written informed consent will be included in the study. Patients will be randomized 1:1 ratio to 1. hemoperfusion cartridge for cytokine sorption in combination with an oXiris membrane and 2. oXiris membrane.

Conditions

• Renal Failure Acute
• Multiple Organ Failure
• Cardiovascular Diseases

Interventions

Type	Name	Description
PROCEDURE	renal replacement therapy	Extracorporeal Methods for Removing Mediators of Systemic Inflammation

Timeline

• Start date: 2021-11-25
• Primary completion: 2024-11-30
• Completion: 2025-05-31
• First posted: 2022-01-10
• Last updated: 2022-02-03

Locations

1 site across 1 country: Russia