NCT01465711

The Value of PSP in Predicting Outcome in ICU Surgical Peritonitis Patients

Diagnostic Accuracy of Pancreatic Stone Protein in Predicting Severe Outcome in Patients With Peritonitis at the Intensive Care Unit

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 137 (actual)
• Sponsor: University of Magdeburg · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine the diagnostic accuracy of Pancreatic Stone Protein (PSP) in predicting patient outcomes with suspected peritonitis in the Intensive Care Unit after abdominal surgery and compare PPS with other blood parameters, including C-Reactive Protein (CRP), White Cell Count (WCC), Interleucin-6 (IL-6) and Procalcitonin (PCT).

Detailed description

Peritonitis is a severe complication after abdominal surgery. Patients admitted at the Intensive Care Unit (ICU) following surgery bear the risk of localized infection, sepsis or septic shock. Prevention or early detection of such events is important to intervene with an appropriate therapeutic action and avoid risking a potentially life-threatening situation. White blood cell counts (WCC) and C-Reactive Protein (CRP), Interleucin-6 (IL-6) and Procalcitonin (PCT) have all been promising parameters, however, they are useful only in selective cases and have a limited diagnostic accuracy.

Conditions

• Peritonitis
• Sepsis
• Multiple Organ Failure
• Death

Interventions

Type	Name	Description
PROCEDURE	All abdominal surgical procedures	Laparotomy, Laparoscopy
PROCEDURE	Intubation	Ventilatory support
RADIATION	Imaging	Abdominal ultrasound Computer Tomography Magnetic Resonance Imaging

Timeline

• Start date: 2007-07-01
• Primary completion: 2014-12-01
• Completion: 2014-12-01
• First posted: 2011-11-07
• Last updated: 2014-12-03

Locations

1 site across 1 country: Germany