| Not Yet Recruiting | Mitochondrial Redox Modulation in Newly Diagnosed Type 2 Diabetes: A Randomized Controlled Trial Comparing Ime NCT07436182 | Mansoura University | Phase 4 |
| Not Yet Recruiting | Interaction Between Inorganic Nitrate Supplementation and Metformin in Individuals With Prediabetes NCT07131384 | University of Virginia | N/A |
| Recruiting | Clinical and Biological Signs of Dapagliflozin Overdose in ICU Patients With Metformin Poisoning NCT07193069 | Centre Hospitalier de Saint-Denis | — |
| Recruiting | Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity NCT06638671 | University of Virginia | Phase 4 |
| Not Yet Recruiting | Study of Acupuncture to Control Weight and Improve Pregnancy Rates in Overweight/Obese PCOS Patients NCT06717087 | RenJi Hospital | N/A |
| Recruiting | Evaluation of the Efficacy and Safety of Metformin in the Myotonic Dystrophy Type 1 (Steinert's Disease) NCT05532813 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Recruiting | Pilot Study on Evaluating the Geroprotective Effect of Metformin NCT06459310 | Xuanwu Hospital, Beijing | Phase 2 |
| Recruiting | Chemoradiotherapy With or Without Metformin in Locally Advanced Cervical Cancer NCT06353061 | Peking Union Medical College Hospital | Phase 2 |
| Recruiting | PCOS Immune Function Predicts Metformin Efficacy NCT06325956 | Shanghai 10th People's Hospital | N/A |
| Recruiting | Effect of Metformin on Healthy Live Birth in Women With Prediabetes NCT06064669 | Shandong University | N/A |
| Recruiting | Phase 2, Open-label, Single-arm Study on the Use of Metformin as Adjunctive Therapy in High-grade Glioma NCT05929495 | University of Milano Bicocca | Phase 2 |
| Completed | Chiglitazar/Metformin in Non-obese Women With PCOS NCT06125587 | Shengjing Hospital | Phase 2 / Phase 3 |
| Enrolling By Invitation | Safety and Feasibility of Metformin for Sepsis Induced AKI NCT05900284 | Hernando Gomez | Phase 2 |
| Completed | PCOS Patients' Immune Alterations NCT06325969 | Shanghai 10th People's Hospital | — |
| Unknown | Effect of Metformin as Add-on Therapy to Ibuprofen on Disease Activity in Knee Osteoarthritis Patients. NCT06126029 | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | Phase 2 |
| Active Not Recruiting | Metabolic Responses of Metformin and Genetic Polymorphisms of SLC22A1 Gene in PCOS NCT05680805 | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | Phase 4 |
| Recruiting | Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes NCT02915198 | VA Office of Research and Development | Phase 4 |
| Unknown | Effects of GLP-1RA on Body Weight, Metabolism and Fat Distribution in Overweight/Obese Patients With Type 2 Di NCT05779644 | RenJi Hospital | N/A |
| Unknown | Treatment With Metformin in Chinese Children With Alport Syndrome NCT05655728 | Peking University First Hospital | Phase 4 |
| Completed | Ameliorating Metabolic Profiling After Kidney Transplantation (AMPKT) NCT05013112 | West China Hospital | N/A |
| Unknown | Interactions of Medicine and Exercise With Meal Timing NCT04477590 | University of Castilla-La Mancha | N/A |
| Unknown | Metformin to Prevent Preterm Birth in Twin Pregnancy NCT05412056 | The University of Hong Kong | Phase 2 / Phase 3 |
| Recruiting | Metformin in Children With Fragile X Syndrome NCT05120505 | Children's Hospital of Fudan University | Phase 4 |
| Unknown | Comparison of Berberine and Metformin for the Treatment for MS in Schizophrenia Patients NCT03708549 | Tianjin Anding Hospital | Phase 4 |
| Recruiting | Effect of Tofogliflozin on UACR Compared to Metformin Hydrochloride in Diabetic Kidney Disease (TRUTH-DKD) NCT05469659 | Shinshu University | Phase 2 |
| Unknown | The Effect of Exercise and Metformin on Carotid Intima-media Thickness in Patients With Prediabetes NCT05052918 | Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey | N/A |
| Completed | DataBase for Analysis of Rectal Cancer Oncological Results NCT04947020 | Jagiellonian University | — |
| Completed | Effects of Exercise and Metformin on Methylglyoxal Levels in Prediabetic Individuals NCT06603480 | Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey | N/A |
| Recruiting | Extending Time Without Diabetes After Bariatric Surgery: a Trial Comparing the Metformin Addition or Not to St NCT04581447 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Unknown | Metformin for the Prevention of CRA Recurrence NCT04885426 | Jing-yuan Fang, MD, Ph. D | N/A |
| Completed | Metformin in Dengue With Obesity NCT04377451 | Oxford University Clinical Research Unit, Vietnam | Phase 1 / Phase 2 |
| Unknown | Perioperative Continuation of Metformin Therapy in Patients With Typ 2 Diabetes Mellitus Undergoing Non-cardia NCT04284722 | Kepler University Hospital | Phase 4 |
| Unknown | Gut Microbiota and Bile Acids in Type 2 Diabetes Mellitus NCT04194515 | Chang Gung Memorial Hospital | — |
| Completed | The POWERED Study: Prophylaxis With Metformin to Prevent PTDM NCT05240274 | Barts & The London NHS Trust | Phase 2 |
| Unknown | A Clinical Trial of Metformin to Decrease Glucocorticoids Side Effects in Patients With Autoimmune Uveitis NCT03525028 | Tianjin Medical University | N/A |
| Completed | Comparison of the Effectiveness Metformin for Deceasing Proliferative Marker in Endometrial Cancer Cells NCT03618472 | Department of Medical Services Ministry of Public Health of Thailand | N/A |
| Completed | Inter- and Intra-individual Variations in Metformin Pharmacokinetics - The Importance of Genes and Drug Intera NCT03335423 | University of Southern Denmark | Phase 1 |
| Unknown | Effect of Metformin as add-on Therapy on Glycemic Control and Other Outcomes in Type 1 Diabetes NCT03590262 | Shenzhen People's Hospital | Phase 4 |
| Unknown | Metformin Induces a Dietary Restriction-like State in Human NCT02745886 | Xiang Guang-da | Phase 4 |
| Unknown | Effects of Metformin on Metabolic and Reproductive Outcomes in Chinese PCOS Patients NCT05463627 | RenJi Hospital | — |
| Completed | Implication of Metformin Plus Aromatase Inhibitor in Obese Postmenopausal Breast Cancer Women NCT05053841 | Tanta University | Phase 2 |
| Terminated | Efficacy of Metformin in Achieving Glycaemia Goals as Recommended for the Treatment of Gestational Diabetes in NCT01756105 | University Hospital, Strasbourg, France | Phase 2 |
| Completed | A Pharmacokinetic Evaluation of Metformin in Relation to the Polymorphism A270S in Healthy Caucasian Volunteer NCT01237522 | University of Southern Denmark | Phase 4 |
| Completed | Study On the Role of Mitochondrial Dysfunction in the Pathogenesis of Metformin-associated Lactic Acidosis NCT00942123 | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | — |
| Completed | Variation in Serum Levels of Metformin in Patients With Reduced Renal Function NCT00767351 | Skane University Hospital | — |