NCT01237522

A Pharmacokinetic Evaluation of Metformin in Relation to the Polymorphism A270S in Healthy Caucasian Volunteers

A Pharmacokinetic Evaluation of Metformin in Relation to the Polymorphism A270S in Healthy Caucasian Volunteers.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: University of Southern Denmark · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The aim of the study is to evaluate the pharmacokinetics of metformin in healthy Caucasians volunteers with and without the polymorphism A270S in OCT2,thus the study hypothesis is that renal clearance of metformin is affected in Caucasian with the known single nucleotide polymorphisms A270S in OCT2.

Conditions

• Metformin
• Organic Cation Transporter 2
• Polymorphism,Single Nucleotide

Interventions

Type	Name	Description
DRUG	Metformin	A single dose study with one tablet of metformin 500 mg, time frame 24 hours

Timeline

• Start date: 2010-08-01
• Primary completion: 2010-12-01
• Completion: 2010-12-01
• First posted: 2010-11-09
• Last updated: 2010-12-29

Locations

1 site across 1 country: Denmark