NCT07193069

Clinical and Biological Signs of Dapagliflozin Overdose in ICU Patients With Metformin Poisoning

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Centre Hospitalier de Saint-Denis · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

This study looks at patients admitted to intensive care for drug poisoning involving metformin, a common diabetes medication. Researchers will compare two groups: patients who overdosed on metformin alone and those who took both metformin and dapagliflozin, another diabetes drug. The goal is to find clinical or laboratory signs that could help doctors quickly recognize a dapagliflozin overdose in this context, which could improve treatment and patient outcomes.

Conditions

• Drug Overdose
• Metformin
• Dapagliflozin
• Lactic Acidosis
• Diabetic Ketoacidosis
• Intensive Care Units

Timeline

• Start date: 2025-04-11
• Primary completion: 2026-04-11
• Completion: 2026-04-11
• First posted: 2025-09-25
• Last updated: 2025-09-25

Locations

1 site across 1 country: France