| Not Yet Recruiting | Justice Community Overdose Innovation Network II TCU Hub NCT07528846 | Texas Christian University | N/A |
| Not Yet Recruiting | Behavioral Safety and Fentanyl Education: BSAFE NCT07219082 | San Francisco Department of Public Health | N/A |
| Recruiting | Clinical and Biological Signs of Dapagliflozin Overdose in ICU Patients With Metformin Poisoning NCT07193069 | Centre Hospitalier de Saint-Denis | — |
| Recruiting | Social Network Overdose Prevention and Education Intervention NCT06327061 | Johns Hopkins Bloomberg School of Public Health | N/A |
| Active Not Recruiting | Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose Risk NCT05657106 | April M Young | N/A |
| Terminated | Evaluation of the Efficacy of Fomepizole in the Treatment of Acetaminophen Overdose NCT05517668 | Richard Dart, MD, PhD | Phase 2 |
| Recruiting | CytOSorb TreatMent Of Critically Ill PatientS Registry NCT05146336 | CytoSorbents, Inc | — |
| Unknown | AI to Improve Data From Danish Cardiac Arrest Registry NCT05308303 | Prehospital Center, Region Zealand | — |
| Recruiting | A Setting Focus Overdose Prevention Intervention NCT05320835 | Johns Hopkins Bloomberg School of Public Health | N/A |
| Completed | Preventing Overdose Using Information and Data From the Environment NCT05096429 | Brown University | N/A |
| Withdrawn | Virtual Overdose Response NCT04391192 | AHS Cancer Control Alberta | N/A |
| Completed | The Rhode Island Prescription and Illicit Drug Study NCT04372238 | Brown University | N/A |
| Completed | Use of Virtual Reality for Overdose Management Educational Trainings NCT04091659 | University of Pennsylvania | N/A |
| Unknown | EEG Monitoring in the Emergency Department NCT04070521 | Massachusetts General Hospital | — |
| Unknown | Development of an Algorithm That Predicts Hypoventilation Due to an Opioid Overdose NCT03845699 | RTM Vital Signs, LLC | — |
| Completed | Repeated-dose Behavioral Intervention to Reduce Opioid Overdose NCT03838510 | San Francisco Department of Public Health | N/A |
| Completed | Feasibility of the Utilization of Buprenorphine in the Emergency Room to Treat Clinical Opioid Withdrawal NCT03489161 | Virginia Commonwealth University | EARLY_Phase 1 |
| Completed | Glucagon's Cardiovascular Effects With and Without Beta-blocker-induced Cardioinhibition NCT03533179 | University Hospital Bispebjerg and Frederiksberg | Phase 4 |
| Completed | Prescribe to Save Lives NCT03175640 | Baystate Medical Center | N/A |
| Completed | Effectiveness of a Postal Intervention to Improve the Use of PPI NCT03840018 | Osakidetza | N/A |
| Completed | Monitored vs Standard Supplementation of Vitamin D in Preterm Infants NCT03087149 | Princess Anna Mazowiecka Hospital, Warsaw, Poland | N/A |
| Completed | A Tailored, Peer-delivered Intervention to Reduce Recurring Opioid Overdoses NCT02922959 | University of Cincinnati | N/A |
| Completed | Effects of Lipid Emulsion on the Pharmacokinetic and Pharmacodynamic Properties of Metoprolol. NCT02924454 | Mikkel Bring Christensen | Phase 4 |
| Completed | Primary Care Intervention to Reduce Prescription Opioid Overdoses NCT02464410 | VA Office of Research and Development | N/A |
| Completed | A Usability Assessment of Naloxone by Community Members NCT03309449 | State University of New York - Upstate Medical University | N/A |
| Unknown | Buccal Versus Injectable Naloxone: a Phase I Healthy Volunteer Study NCT02733822 | King's College London | Phase 1 |
| Completed | Bioavailability of Nasal Naloxone and Injected Naloxone Compared NCT02598856 | Norwegian University of Science and Technology | Phase 1 |
| Completed | Pharmacodynamics and Arteriovenous Differences of Naloxone in Healthy Participants Exposed to an Opioid NCT02405988 | Norwegian University of Science and Technology | N/A |
| Completed | Pharmacokinetics and Pharmacodynamics of a New Formulation of Nasal Naloxone for Prehospital Use NCT02307721 | Norwegian University of Science and Technology | Phase 1 / Phase 2 |
| Completed | Safety and Health Intervention Project NCT02152397 | University of Michigan | N/A |
| Completed | Pharmacokinetic Evaluation of Intranasal and Intramuscular Naloxone in Healthy Volunteers NCT02572089 | National Institute on Drug Abuse (NIDA) | Phase 1 |
| Completed | Phone Interview to Prevent Recurring Opioid Overdoses NCT02282306 | University of Cincinnati | N/A |
| Completed | Repeated-dose Brief Intervention to Reduce Overdose and Risk Behaviors Among Naloxone Recipients NCT02093559 | San Francisco Department of Public Health | N/A |
| Completed | Bioavailability of a New Formulation of Nasal Naloxone for Prehospital Use NCT02158117 | Norwegian University of Science and Technology | Phase 1 |
| Unknown | Nasal Naloxone for Narcotic Overdose NCT01912573 | Judith Feinberg | Phase 4 |
| Completed | A Pilot Study of the Bioavailability of Nasal Naloxone NCT01939444 | Norwegian University of Science and Technology | Phase 2 |
| Completed | Safety & Prevention Outcomes Study NCT01894087 | University of Michigan | N/A |