NCT03838510

Repeated-dose Behavioral Intervention to Reduce Opioid Overdose

Repeated-dose Behavioral Intervention to Reduce Opioid Overdose: A Two-Site Randomized-Controlled Efficacy Trial (REBOOT)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 268 (actual)
• Sponsor: San Francisco Department of Public Health · Other Government
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

REBOOT is a randomized trial of a repeated-dose brief intervention to reduce overdose and risk behaviors among naloxone recipients with opioid use disorder. It includes an established overdose education curriculum within an Informational-Motivation-Behavior (IMB) model. This study will test the efficacy of REBOOT vs attention-control.

Conditions

• Opioid-Related Disorders
• Drug Overdose

Interventions

Type	Name	Description
BEHAVIORAL	REBOOT	The brief counseling intervention will utilize Motivational Interviewing and skills-building techniques to modify personal overdose risk behaviors and develop skills as a peer responder for witnessed overdose. The counselor will draw upon themes of safer substance use to address overdose risk behaviors and determine readiness for change in substance use.

Timeline

• Start date: 2019-04-22
• Primary completion: 2023-12-12
• Completion: 2023-12-12
• First posted: 2019-02-12
• Last updated: 2025-06-15
• Results posted: 2025-06-15

Locations

2 sites across 1 country: United States