| Recruiting | An Assessment of Efficacy, Safety, and Pharmacokinetics of NBI-1117568 in Adults With Bipolar I Disorder With NCT07288320 | Neurocrine Biosciences | Phase 2 |
| Recruiting | A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mi NCT07140913 | Bristol-Myers Squibb | Phase 3 |
| Not Yet Recruiting | Effect of Blue Light Blocking on Reducing Manic Symptoms in Bipolar Disorder NCT06748716 | Rayan NASSERDINE | N/A |
| Completed | Clocks in Sync - Circadian Rhythm and Bipolar Mania NCT06504342 | Ottawa Hospital Research Institute | N/A |
| Recruiting | Combining mHealth and Nurse-delivered Care to Improve the Outcomes of People With Serious Mental Illness in We NCT05703711 | University of Washington | N/A |
| Completed | Long-acting Injectable Antipsychotics for Mental Ill-Health in Pregnancy and Postpartum NCT05766007 | University of Liverpool | — |
| Completed | Ottawa Sunglasses at Night for Mania Study NCT05206747 | Ottawa Hospital Research Institute | N/A |
| Unknown | Impact of Closely Grouped, Iterative Exposures to Suxamethonium During ECT on the Sensitization to NMBA and th NCT05210062 | Assistance Publique - Hôpitaux de Paris | — |
| Recruiting | Deep Brain Stimulation-Induced Mania in Parkinson's Disease NCT05444907 | Albino Maia | — |
| Completed | A Cariprazine Study in the Prevention of Relapse in Bipolar I Disorder Patients Whose Current Episode is Manic NCT03573297 | AbbVie | Phase 3 |
| Withdrawn | Open-Label Study of Latuda for the Treatment of Mania in Children and Adolescents 6-17 Years Old NCT01932541 | Massachusetts General Hospital | Phase 4 |
| Completed | Pediatric Bipolar Registry NCT02360267 | The University of Texas Health Science Center, Houston | — |
| Completed | Methylphenidate for the Treatment of Acute Mania NCT01541605 | Michael Kluge | Phase 3 |
| Completed | Virtual Darkness as Additive Treatment in Mania NCT01818622 | Helse Fonna | N/A |
| Unknown | Assessment of Cardiac Autonomic Behavior in Patients With Mood Disorders NCT01272518 | Sao Jose do Rio Preto Medical School | — |
| Completed | Bipolar Intervention Study: Cognitive Interpersonal Therapy NCT01315028 | NHS Greater Glasgow and Clyde | N/A |
| Completed | Peroxisomal Defects and Familial Risk for Bipolar Disorder NCT01237379 | University of Cincinnati | — |
| Completed | Trial of Citicoline Therapy in Patients With Mania or Hypomania and Cocaine Abuse/Dependence NCT00223236 | University of Texas Southwestern Medical Center | Phase 3 |
| Completed | Allopurinol for Mania: A Randomized Trial Administering Allopurinol vs. Placebo as add-on to Mood Stabilizers NCT01092221 | Sheba Medical Center | Phase 3 |
| Completed | Treatment of Alcohol Dependence and Comorbid Bipolar Disorder NCT01015586 | Medical University of South Carolina | Phase 4 |
| Completed | Safety and Efficacy of Cariprazine for Mania NCT01058096 | Forest Laboratories | Phase 3 |
| Completed | Safety and Efficacy of Cariprazine for Bipolar I Disorder NCT01058668 | Forest Laboratories | Phase 3 |
| Completed | Neurochemical Effects of Omega-3 Fatty Acids in Adolescents at Risk for Mania NCT00917501 | University of Cincinnati | Phase 2 |
| Completed | Multimodal Neuroimaging of Treatment Effects in Adolescent Mania NCT00893581 | University of Cincinnati | N/A |
| Terminated | Allopurinol Maintenance Study for Bipolar Disorder NCT00732251 | Cedars-Sinai Medical Center | Phase 4 |
| Completed | Effectiveness of Quetiapine XR on the Control of Symptoms of Manic Phase of Bipolar Disorder. NCT00521365 | AstraZeneca | Phase 4 |
| Completed | Non-interventional Study of Ziprasidone in the Treatment of Bipolar and Schizoaffective Disorders. NCT00454883 | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | — |
| Completed | Effects of Pentazocine Versus Lorazepam on Manic Symptoms NCT00431184 | Mclean Hospital | Phase 2 |
| Unknown | Safety and Efficacy Study of Lithium in Bipolar Disorder NCT00422331 | JDS Pharmaceuticals | Phase 3 |
| Completed | Phase 3 /Seroquel SR Acute Mania Monotherapy - US NCT00422123 | AstraZeneca | Phase 3 |
| Completed | A Comparison Study of the Efficacy and Tolerability of Depakote ER and Depakote DR NCT00334347 | Massachusetts General Hospital | Phase 4 |
| Completed | A Study to Evaluate the Efficacy and Safety of Adjustable Doses of Extended-release (ER) Paliperidone Compared NCT00309686 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Phase 3 |
| Completed | Treatment of Bipolar Mania in Older Adults NCT00254488 | Weill Medical College of Cornell University | Phase 4 |
| Completed | Unraveling the Relation of Patient's Profile and Therapeutical Effects of Atypicals, Including Quetiapine Effe NCT00534222 | AstraZeneca | — |
| Completed | Efficacy and Safety of Seroquel and Lithium as Monotherapy in Acute Mania Treatment in Bipolar Disorder Patien NCT00448578 | AstraZeneca | Phase 3 |
| Completed | Equetro for the Treatment of Mania in Children Ages 6-12 With Bipolar Disorder NCT00181870 | Massachusetts General Hospital | Phase 4 |
| Completed | The Efficacy and Safety of AChE Inhibitor Donepezil As Adjunctive Treatment to Mood Stabilizers in Acute Mania NCT01191918 | Shanghai Mental Health Center | Phase 4 |
| Completed | Taurine as an Anti-Manic Agent: A Double-Blind, Placebo-Controlled Study NCT00217165 | Mclean Hospital | Phase 2 |
| Completed | Quetiapine for Mania In Preschool Children 4 to 6 Years of Age With Bipolar Disorder NCT00181883 | Massachusetts General Hospital | Phase 4 |
| Completed | Lamotrigine for the Treatment of Mania in Youth Ages 6-17 With Bipolar Disorder NCT00181844 | Massachusetts General Hospital | Phase 4 |
| Completed | Valnoctamide in Mania NCT00140179 | Beersheva Mental Health Center | Phase 3 |
| Completed | Aripiprazole Pharmacokinetics (PK) and Tolerability Study in Children and Adolescents NCT00102479 | Otsuka Pharmaceutical Development & Commercialization, Inc. | Phase 2 |
| Completed | Depakote ER Therapy for Mania Comorbid With Substance Abuse NCT00208195 | Creighton University | Phase 4 |
| Completed | Reliability and Validity of the MINI International Neuropsychiatric Interview for Children and Adolescents (MI NCT00579267 | University of South Florida | — |
| Completed | Study of Depakote ER for the Treatment of Mania in Children Ages 6-12 With Bipolar Disorder NCT00181727 | Massachusetts General Hospital | Phase 4 |
| Completed | Anti-Estrogens - A Potential Treatment for Bipolar Affective Disorder in Women? NCT00206544 | The Alfred | Phase 2 |
| Completed | Efficacy of Allopurinol and Dypiridamole in Acute Mania NCT00560079 | Hospital Espirita de Porto Alegre | Phase 4 |
| Completed | A Study of the Efficacy and Safety of Intramuscular Ziprasidone Followed by Oral Ziprasidone for the Treatment NCT00644800 | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | Phase 4 |
| Completed | Aripiprazole for the Treatment of Mania in Children and Adolescents With Bipolar Disorder NCT00181779 | Massachusetts General Hospital | Phase 4 |
| Completed | Ziprasidone for the Treatment of Mania in Children and Adolescents With Bipolar Disorder NCT00181922 | Massachusetts General Hospital | Phase 4 |
| Completed | Risperidone Versus Olanzapine for Mania in Preschool Children 4 to 6 Years of Age With Bipolar Disorder NCT00181935 | Massachusetts General Hospital | Phase 4 |
| Completed | Pharmacotherapy of Treatment-Resistant Mania NCT00518947 | University of Pittsburgh | Phase 3 |