| Recruiting | Fast TILs to Treat Metastatic Pleural Effusions From Epithelial or Mesothelial Primary Tumors NCT07443020 | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | Phase 1 |
| Recruiting | Fast TILs to Treat Metastatic Cancer Patients With Pleural Disease NCT07192900 | David Bartlett, MD | Phase 1 |
| Not Yet Recruiting | Effectiveness of Intercostal Tube Drainage Vs Pigtail Catheter Drainage Vs Ultrasound-Guided Aspiration in Man NCT06964321 | Assiut University | N/A |
| Recruiting | Impact of Patient Position on Chemical Pleurodesis by Chest Ultrasound NCT07147270 | Ain Shams University | N/A |
| Not Yet Recruiting | Pleural Bleomycin vs Mechanical Abrasion in Malignant Pleural Effusion NCT06691009 | Assiut University | N/A |
| Withdrawn | Defining the Clinical Potential of Mass Response As a Biomarker for Patient Tumor Sensitivity to Drugs NCT04985357 | Travera Inc | — |
| Completed | Cytological Examination of Malignant Pleural Effusion in Breast Cancer NCT06657638 | Mansoura University Hospital | — |
| Recruiting | A Study of MT027 in Patients with Pleural Malignant Tumors NCT06726564 | Suzhou Maximum Bio-tech Co., Ltd. | Phase 1 |
| Recruiting | Tocilizumab Delivered Via Pleural and Peritoneal Catheters in Patients With Advanced Metastatic Cancer NCT06016179 | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | Phase 1 |
| Recruiting | Feasibility of Ambulatory Talc. Pleurodesis NCT06682936 | David Rollins | N/A |
| Recruiting | OPC5: Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) in Patients With Malignant Pleural Effusion. NCT06421610 | Odense University Hospital | Phase 1 |
| Unknown | A Phase I Study of JMKX000197 Injection in the Treatment of Malignant Pleural Effusion NCT05923515 | Jemincare | Phase 1 |
| Unknown | A Prospective Observational Study on the Role of Transthoracic Ultrasound in Differentiating Tuberculous From NCT05935696 | Sarawak General Hospital | — |
| Unknown | Video Assisted Thoracoscopic Surgery (VATS) - Surgical Pleurodesis vs Tube Drainage in Management of Malignant NCT05872126 | Assiut University | N/A |
| Unknown | A Study of Intrapleural Administration of Bevacizumab and Camrelizumab for Malignant Pleural Effusion NCT05330065 | The First Affiliated Hospital of Zhengzhou University | Phase 1 / Phase 2 |
| Completed | Malignant Pleural Effusions: Evaluating the psYchosocial Impact of Indwelling Pleural Catheters on Patients NCT05372055 | Guy's and St Thomas' NHS Foundation Trust | — |
| Unknown | Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/Metastatic Solid Tumors Including NCT05278975 | RS Oncology LLC | Phase 1 / Phase 2 |
| Active Not Recruiting | A Phase Ⅲ Clinical Study of Combined Cisplatin Versus Placebo Combined With Intracavitary Cisplatin Injection NCT04914598 | Jiangsu Simcere Pharmaceutical Co., Ltd. | Phase 3 |
| Unknown | A Multicenter Survey Study Into Patient Experience With Mobile Apps NCT05130697 | National University of Ireland, Galway, Ireland | — |
| Terminated | Randomized Controlled Trial of Talc Instillation In Addition To Daily Drainage Through a Tunneled Pleural Cath NCT04792970 | Duke University | Phase 4 |
| Unknown | Oncodrivers in Malignant Pleural Effusions Associated With Non-small Cell Lung Cancer: A Prospective Study. NCT04806412 | Naestved Hospital | N/A |
| Unknown | Interventions for Malignant Pleural Effusions Impact on Fatigue NCT04793607 | Northumbria Healthcare NHS Foundation Trust | — |
| Unknown | Safety and Efficacy Study of Virus Activated Killer Immune Cells (VAK) for Malignant Pleural and Peritoneal Ef NCT05565014 | Sheng Hu | EARLY_Phase 1 |
| Completed | Value of Additional Upfront Systematic Lung Ultrasound in the Workup of Patients With Unilateral Pleural Effus NCT04235998 | Naestved Hospital | — |
| Completed | Quantitative Diaphragmatic Ultrasound Evaluation in Pleural Effusions : A Feasability Study NCT04264325 | University Hospital, Strasbourg, France | — |
| Completed | A Phase I Study Evaluating SCB-313(Recombinant Human TRAIL-Trimer Fusion Protein) for the Treatment of Maligna NCT04123886 | Sichuan Clover Biopharmaceuticals, Inc. | Phase 1 |
| Terminated | Ultrasound-guided Biopsy of the Pleura as a Supplement to Extraction of Fluid in Patients With One-sided Fluid NCT04236037 | Naestved Hospital | N/A |
| Unknown | Safety and Effectiveness of MPCD Therapy on the Treatment of Malignant Pleural Effusion NCT04131231 | Peking Union Medical College | N/A |
| Unknown | Comparison of the Effectiveness of Povidone-Iodine Alone to Povidone-Iodine-Tetracycline Combination NCT04039126 | University College Hospital, Ibadan | Phase 1 |
| Unknown | Talc Outpatient Pleurodesis With Indwelling Catheter NCT03973957 | The Cooper Health System | N/A |
| Terminated | A Study of Nivolumab and Intrapleural Talimogene Laherparepvec for Malignant Pleural Effusion NCT03597009 | UNC Lineberger Comprehensive Cancer Center | Phase 1 / Phase 2 |
| Unknown | A Study of Syngenon (BSG-001) for Inhalation in Subjects With Malignant Pleural Effusion and/or Malignant Asci NCT03736122 | BioSyngen Pte Ltd | Phase 1 / Phase 2 |
| Unknown | A Randomized Study of Primary Tumor Radiotherapy for Patients With MPE Stage IV NSCLC NCT03987087 | Guizhou Medical University | Phase 2 |
| Completed | Management of Malignant Pleural Effusions Using an Indwelling Tunneled Pleural Catheter and Non-Vacuum Collect NCT03414905 | Washington University School of Medicine | — |
| Withdrawn | Betadine Pleurodesis Via Tunneled Pleural Catheters NCT02975921 | Yale University | Phase 4 |
| Unknown | AMPLE-3: IPC Plus Talc vs VATS in Management of Malignant Pleural Effusion NCT04322136 | The University of Western Australia | N/A |
| Unknown | Rocket® Pleural Catheters: QOL, Feasibility and Satisfaction in Recurrent MPE Patients NCT03403855 | Ottawa Hospital Research Institute | N/A |
| Unknown | Activity Behaviours in Patients With Malignant Pleural Effusion NCT03482570 | The University of Hong Kong | — |
| Unknown | Malignant Pleural Effusion: Pleur-X vs. Chemical Pleurodesis in VATS NCT03518788 | Rolf Inderbitzi | N/A |
| Recruiting | UNC Pleural Fluid Registry NCT05620329 | UNC Lineberger Comprehensive Cancer Center | — |
| Unknown | Bevacizumab in the Treatment of Malignant Pleural Effusions of Non-squamous Non-small Cell Lung Cancer NCT02942043 | Peking University Cancer Hospital & Institute | Phase 2 |
| Completed | The Experiences of Patients Living With Malignant Pleural Effusions NCT03235999 | Gloucestershire Hospitals NHS Foundation Trust | — |
| Completed | Safety and Effectiveness of a New Pleural Catheter for Symptomatic, Recurrent, MPEs Versus Approved Pleural Ca NCT02649894 | C. R. Bard | N/A |
| Unknown | Clinical Trial of Tumor Cell-derived Microparticles Packaging Chemotherapeutic Drugs to Treat Malignant Pleura NCT02657460 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Phase 2 |
| Completed | Efficacy of Iodopovidone Versus Talc in Palliative Malignant Pleural Effusion NCT02674243 | Chiang Mai University | Phase 3 |
| Completed | A Study to Compare the Efficacy and Safety of Intrapleural Doxycycline Versus Iodopovidone for Performing Pleu NCT02583282 | Post Graduate Institute of Medical Education and Research, Chandigarh | N/A |
| Unknown | Recombinant Adenoviral Human p53 Gene in Treatment of Malignant Pleural Effusion NCT02429726 | Shenzhen SiBiono GeneTech Co.,Ltd | Phase 2 |
| Completed | Using Thoracic Ultrasound to Predict Pleurodesis Success in Malignant Pleural Effusions: a Pilot Study NCT02625675 | University of Oxford | — |
| Terminated | Genetic Sequencing-Informed Targeted Therapy in Treating Patients With Stage IIIB-IV Non-small Cell Lung Cance NCT02132884 | Fox Chase Cancer Center | N/A |
| Completed | Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritone NCT02122185 | University of Chicago | Phase 2 |
| Completed | Intrapleural Bevacizumab Injection for Malignant Effusion in Lung Cancer NCT02054052 | Haihong Yang, MD, Pricipal investigator | Phase 2 |
| Completed | Intrapleural AdV-tk Therapy in Patients With Malignant Pleural Effusion NCT01997190 | Candel Therapeutics, Inc. | Phase 1 |
| Unknown | Safety and Effectiveness Study of Tumor Cell-derived Microparticles to Treat Malignant Ascites and Pleural Eff NCT01854866 | Huazhong University of Science and Technology | Phase 2 |
| Unknown | Efficacy and Safety of Bevacizumab Versus Pulvis Talci in Malignant Pleural Effusion NCT02054078 | Tang-Du Hospital | Phase 2 |
| Unknown | Effectiveness of Doxycycline for Treating Pleural Effusions Related to Cancer in an Outpatient Population NCT01411202 | Ottawa Hospital Research Institute | Phase 2 |
| Completed | Endostar and/or Cisplatin for Treatment of Malignant Pleural Effusion or Ascites NCT01327235 | Jiangsu Simcere Pharmaceutical Co., Ltd. | Phase 2 |
| Completed | Efficacy and Safety Study of Abnoba Viscum F 20mg in Malignant Pleural Effusion Patients NCT02191540 | Abnoba Korea | Phase 3 |
| Terminated | Cediranib as Palliative Treatment in Patients With Symptomatic Malignant Ascites or Pleural Effusion NCT01262612 | Radboud University Medical Center | Phase 2 |
| Terminated | Zometa Adjuvant Treatment of Malignant Pleural Effusion Due To Non-Small Cell Lung Cancer NCT01004510 | Peter Bushunow MD | Phase 2 |
| Unknown | Safety and Effectiveness Study for Pleurodesis With Silver Nitrate in Malignant Pleural Effusion NCT01125124 | University of Sao Paulo General Hospital | Phase 2 |
| Completed | Intrapleural Bevacizumab and Cisplatin Therapy for Malignant Pleural Effusion Caused by Non-small Cell Lung Ca NCT01661790 | Chinese PLA General Hospital | Phase 3 |
| Completed | The First Therapeutic Intervention in Malignant Pleural Effusion Trial NCT00896285 | University of California, Davis | N/A |
| Completed | Tunneled Pleural Catheter in Partially Entrapped Lung NCT00637676 | Heidelberg University | Phase 2 |
| Completed | AZD0530 in Treating Patients With Extensive Stage Small Cell Lung Cancer NCT00528645 | National Cancer Institute (NCI) | Phase 2 |
| Completed | FDG-Labeled PET Scan in Planning Chemotherapy in Treating Patients With Stage IIIB or IV Non-Small Cell Lung C NCT00564733 | University of Washington | Phase 2 |
| Completed | Imatinib Mesylate and Paclitaxel in Treating Older Patients With Stage IIIB or Stage IV Non-Small Cell Lung Ca NCT00408460 | University of Washington | Phase 2 |
| Unknown | Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion NCT00313066 | Taichung Veterans General Hospital | — |
| Completed | Erlotinib Hydrochloride With or Without Carboplatin and Paclitaxel in Treating Patients With Stage III-IV Non- NCT00126581 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Docetaxel With Either Cetuximab or Bortezomib as First-Line Therapy in Treating Patients With Stage III or Sta NCT00118183 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Bortezomib Plus Gemcitabine and Carboplatin in Treating Patients With Advanced or Recurrent Non-Small Cell Lun NCT00052338 | National Cancer Institute (NCI) | Phase 1 |
| Completed | Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu NCT00004074 | National Cancer Institute (NCI) | Phase 1 |