| Not Yet Recruiting | A Machine Learning-Based Risk Prediction Model for Head and Neck Cancerous Lesions NCT07532538 | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | — |
| Recruiting | Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatme NCT07209189 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Phase 2 |
| Not Yet Recruiting | Validation of End-to-End Difficult Airway Pathway Planning Algorithm (EAP-LC) NCT07324317 | Eye & ENT Hospital of Fudan University | — |
| Recruiting | Thermoradiotherapy for Locally Advanced Head and Neck Cancer Patients NCT06761937 | Erasmus Medical Center | Phase 1 |
| Recruiting | SBRT Followed by Chemoimmunotherapy of Toripalimab Plus Docetaxel and Cisplatin for Larynx Preservation in Pat NCT06611137 | Sun Yat-sen University | Phase 2 |
| Unknown | Oncologic and Functional Outcome and Quality of Life in Patients Treated for Laryngeal Cancer NCT06784401 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | — |
| Not Yet Recruiting | Tislelizumab and Induction Chemotherapy for Larynx Preservation in Resectable Advanced Laryngeal/Hypopharyngea NCT06554028 | Henan Cancer Hospital | Phase 2 |
| Recruiting | European Larynx Organ Preservation Study (ELOS) [MK-3475-C44] NCT06137378 | University of Leipzig | Phase 2 |
| Unknown | Study of the Risk of Pharyngocutaneous Fistula in a Population of Patients Undergoing Total Laryngectomy and C NCT06308016 | Regina Elena Cancer Institute | — |
| Recruiting | Workshops and Exchange Groups for Laryngectomized Patients NCT06077643 | Assistance Publique - Hôpitaux de Paris | — |
| Recruiting | The Voice as a Tool to Detect Recurrence of Laryngeal and Hypopharyngeal Cancer NCT05894070 | Insel Gruppe AG, University Hospital Bern | — |
| Unknown | A Clinical Study on Oncolytic Virus Injection (R130 OV) for the Treatment of Relapsed/Refractory Head and Neck NCT05830240 | Shanghai Yunying Medical Technology | EARLY_Phase 1 |
| Unknown | Using the Subglottic Pressure to Predict the Dysphagia After Partial Laryngectomy NCT06024980 | Guangdong Provincial People's Hospital | N/A |
| Unknown | Oxidative Stress and Inflammation Biomarkers in Surgically Treated Patients With Laryngeal Cancer NCT05857202 | Clinical Centre of Serbia | — |
| Completed | SpeakFree Heat and Moisture Exchanger (HME) NCT05349487 | University of Miami | N/A |
| Recruiting | Immune Biomarker Study for Head and Neck Cancer NCT05375266 | University of Erlangen-Nürnberg Medical School | — |
| Completed | Effects of Oral Aloe Vera Juice on Chemotherapy and Radiation-induced Oral Mucositis and Esophagitis NCT05369234 | Covenant Health Cancer Center | Phase 3 |
| Unknown | Induction Chemotherapy and Toripalimab for Larynx Preservation in Resectable Laryngeal/Hypopharyngeal Carcinom NCT04995120 | Fudan University | Phase 2 |
| Unknown | Induction Chemotherapy and Toripalimab Followed by Radiotherapy in Unresectable Laryngeal/Hypopharyngeal Carci NCT05420597 | Fudan University | Phase 2 |
| Recruiting | Aortic Laryngeal Rehabilitation Graft NCT04650919 | University Hospital, Strasbourg, France | N/A |
| Unknown | Perioperative ERAS Based Nursing Intervention for Laryngeal Cancer Patients NCT04174950 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Completed | Wound Complications in Head and Neck Surgery NCT03134976 | University of Michigan | — |
| Unknown | A Novel Modified Tracheo-Esophageal Voice Prosthesis for Total Laryngectomy Patients NCT03039465 | HealthCare Global Enterprise Ltd. | N/A |
| Terminated | NewBreez for Airway Protection in Head and Neck Cancer Patients With Chronic Aspiration NCT02437513 | ProTiP Medical | — |
| Completed | Pembrolizumab in Combination With CRT for LA-SCCHN NCT02586207 | Sanford Health | Phase 1 |
| Recruiting | Integrated Cancer Repository for Cancer Research NCT02012699 | University of Nebraska | — |
| Completed | Phonosurgical Augmentation After Laser Resection of Early Glottic Carcinoma NCT04525066 | Ayhman Al Afif | Phase 2 |
| Unknown | Nomograms to Precisely Predict Conditional Risk of Survival for Patients With Laryngeal Cancer NCT03747783 | First Affiliated Hospital, Sun Yat-Sen University | — |
| Completed | Chemotherapy AND Bcl-xL Inhibitor (AT-101) For Organ Preservation In Adults With Advanced Laryngeal Cancer NCT01633541 | University of Michigan Rogel Cancer Center | Phase 2 |
| Completed | A Phase II Study In Patients With Advanced Head And Neck Cancer Of Standard Chemoradiation And Add-On Cetuxima NCT01435252 | University of Zurich | Phase 2 |
| Completed | Resistance Training During Radiation Therapy for Pharyngeal or Laryngeal Cancer NCT00827164 | University of Alabama at Birmingham | Phase 2 |
| Completed | Observational Study of Swallowing Function After Treatment of Advanced Laryngeal Cancer NCT01089803 | University of Minnesota | — |
| Completed | Resistance Training and Physical Functioning in Head and Neck Cancer Patients NCT01332682 | University of Alabama at Birmingham | Phase 1 |
| Completed | Radiation Therapy and Bortezomib and Cetuximab With or Without Cisplatin to Treat Head and Neck Cancer NCT01445405 | National Cancer Institute (NCI) | Phase 1 |
| Unknown | The Role of MMPs in the CXCL12-Induced Invasion of Laryngeal and Hypopharyngeal Squamous Cell Carcinoma NCT00302562 | National Taiwan University Hospital | — |
| Unknown | The Role of Stromal Cell-Derived Factor-1 (SDF-1)/CXC Chemokine Receptor 4 (CXCR4) in Metastasis of Laryngeal NCT00174096 | National Taiwan University Hospital | — |
| Unknown | The Role of Lymphangiogenesis in Head and Neck Cancer Metastasis NCT00173381 | National Taiwan University Hospital | — |
| Completed | Comparison of 2 Cefazolin Prophylactic Protocol in Laryngectomy Patients NCT00467948 | Tehran University of Medical Sciences | Phase 3 |
| Terminated | Patient Evaluation for Head and Neck Surgery Branch Studies NCT00011492 | National Institute on Deafness and Other Communication Disorders (NIDCD) | — |
| Completed | Efficacy of Hyperbaric Oxygen Therapy in Laryngectomy Patients NCT00026975 | National Center for Complementary and Integrative Health (NCCIH) | Phase 2 |