NCT00467948

Comparison of 2 Cefazolin Prophylactic Protocol in Laryngectomy Patients

Double Blind Randomised Study of 2 Days and 5 Days Cefazolin Prophylactic Method in Laryngeal Oncologic Surgery

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: Tehran University of Medical Sciences · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Patients who need major head \& neck surgery are at risk of post operative wound infection. In spite of role of antibiotics in prophylaxis of clean contaminated head and neck surgery has been well documented, controversy exists in the optimal antibiotic regimen

Detailed description

Patients undergoing laryngeal oncologic surgery are at relatively high risk of developing complication. Efficacy of cefazolin as a prophylactic antibiotic in head and neck surgery was reviewed in many researches \[6\] but considering the costs and morbidities of prolonged antibiotic regimen we have presented a prospective and randomized study in 90 patients comparing the efficacy of 2 day over 5 day protocols.

Conditions

• Laryngeal Cancer

Interventions

Type	Name	Description
DRUG	cefazolin

Timeline

• Start date: 2004-06-01
• Completion: 2006-03-01
• First posted: 2007-05-01
• Last updated: 2007-05-01

Locations

1 site across 1 country: Iran