| Not Yet Recruiting | Knee Arthroplasty Recovery With Transcranial Direct Current Stimulation NCT07351578 | Women's College Hospital | N/A |
| Not Yet Recruiting | The Impact of Patient Education Delivered Through Virtual Reality NCT07247903 | Ankara Yildirim Beyazıt University | N/A |
| Not Yet Recruiting | Risk of Serious Adverse Events Following Unsupervised vs Supervised Rehabilitation After Knee Arthroplasty NCT07067060 | Copenhagen University Hospital, Hvidovre | — |
| Not Yet Recruiting | Effectiveness, Satisfaction, and Usability of Virtual Reality in the Management of Postoperative Pain in Patie NCT07286084 | Universidad Francisco de Vitoria | N/A |
| Not Yet Recruiting | The Effect of Rehabilitative Nursing Care Practices on Frail Patients Undergoing Knee Arthroplasty and Their C NCT07201454 | Ataturk University | N/A |
| Recruiting | Development of an Outcome Score for Patients With Knee Osteoarthritis and Knee Joint Endoprosthesis Using an A NCT07212699 | Technical University of Munich | N/A |
| Completed | Ketamine Administration for Postoperative Pain Management in Patients Undergoing Knee Arthroplasty NCT07059429 | State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia | N/A |
| Recruiting | Effect of Music Listened During Knee Arthroplasty With Spinal Anesthesia on Anxiety, Pain and Cortisol Levels NCT06729294 | Nuh Naci Yazgan University | N/A |
| Not Yet Recruiting | The Dubousset Functional Test in Total Knee Arthloplasty NCT06634212 | Alanya Alaaddin Keykubat University | — |
| Completed | Postoperative Analgesis in Total Knee Arthroplasty NCT06498557 | Senay Canikli | — |
| Completed | The Impact of Web-Based Education on Self-Care Power, Self-Efficacy, and Quality of Life in Knee Arthroplasty NCT06306027 | KTO Karatay University | N/A |
| Completed | Tactile Incentiviser Improves Partial Weight Bearing After Lower-Limb Surgery NCT06989554 | Università degli Studi dell'Insubria | N/A |
| Completed | Increased Perioperative Communication Program in Knee Arthroplasty NCT06130813 | Hacettepe University | N/A |
| Unknown | the 95% Effective Dose of Ciprofol for Adjunctive Sedation Undergoing Knee Arthroplasty in Elderly People NCT06293144 | Second Hospital of Shanxi Medical University | EARLY_Phase 1 |
| Completed | The Energize! Study for Adults With Knee Replacement NCT06096727 | University of South Carolina | N/A |
| Completed | Efficacy of Proprioceptive Neuromuscular Facilitation Exercise Programme in Patients With Total Knee Arthropla NCT05999864 | Muğla Sıtkı Koçman University | N/A |
| Completed | Effectiveness of Dual Task Training in Total Knee Arthroplasty NCT06009380 | Muğla Sıtkı Koçman University | N/A |
| Completed | Median Effective Dose of Ciprofol-Assisted Sedation for Elderly Patients Undergoing Knee Arthroplasty NCT06293131 | Second Hospital of Shanxi Medical University | EARLY_Phase 1 |
| Completed | Effectiveness of Relaxation Methods in Total Knee Arthroplasty Patients NCT06009341 | Muğla Sıtkı Koçman University | N/A |
| Recruiting | Yale Steroid Enhanced Versus Exparel Nerveblock TKA Part 2 NCT05736549 | Yale University | Phase 2 |
| Completed | First Mobilization Protocol for Total Knee Arthroplasty Patients NCT06268899 | Gazi University | N/A |
| Recruiting | Yale Steroid Enhanced Versus Exparel Nerveblock TKA RCT Study NCT05279092 | Yale University | Phase 2 |
| Completed | The Efficacy of Kinesiotaping on Pain, Edema and Functionality After Total Knee Arthroplasty NCT05457686 | Kirsehir Ahi Evran Universitesi | N/A |
| Completed | PMCF Study to Evaluate Safety of TIPMED TPM08 Total Knee Prosthesis Systems and TPM Revision Knee Prosthesis S NCT05400447 | TIPMED Medical Device Manufacturing Ltd. Co. | — |
| Completed | Investigating the Efficacy of Osteopathic Manipulative Treatment on Gait Dysfunction Following Knee Surgery NCT05580640 | Midwestern University | N/A |
| Completed | Limited Market Release - MotionSense Clinical Use Evaluation NCT05091918 | Orthosensor, Inc. | N/A |
| Unknown | Balance After Knee Arthroplasty NCT04681404 | Johannes Kepler University of Linz | N/A |
| Completed | Unicompartmental Knee Arthroplasty vs High Tibial Osteotomy. NCT04467970 | Assiut University | N/A |
| Completed | Backwards Walking Programme Following Hip and Knee Arthroplasty NCT04247802 | Oxford University Hospitals NHS Trust | N/A |
| Completed | Technology Interventions to Improve Outcomes After Knee Replacement NCT04482400 | University of South Carolina | N/A |
| Withdrawn | Comparing Two Regional Anesthesia Interventions for Knee Arthroplasty. NCT03944005 | Western University, Canada | N/A |
| Unknown | Effect Of Aspirin Preoperative on Postoperative Cognitive Dysfunction In Elderly Patients Undergoing Knee Arth NCT04225702 | Xuzhou Medical University | — |
| Completed | Physiotherapy and Therapeutic Education on Patients With Pain Catastrophism Scheduled for a Total Knee Arthrop NCT03847324 | University of Barcelona | N/A |
| Unknown | Multimodal Modeling of the Knee Joint NCT04179812 | University Hospital, Brest | — |
| Completed | Continuous Monitoring of Physiology and Self-reported Pain Score Amongst Post-surgical Knee Patients NCT03789630 | Biofourmis Singapore Pte Ltd. | — |
| Completed | The PATH Study to Promote Physical Activity After Knee Replacement NCT03768206 | University of South Carolina | N/A |
| Completed | Routine Surgical Procedures During COVID-19 Pandemic: a French Nationwide Cohort Study NCT05197660 | EPI-PHARE | — |
| Terminated | Dexmedetomidine Combined With Ropivacaine for Postoperative Continuous Femoral Nerve Block NCT03629483 | Peking University First Hospital | Phase 4 |
| Completed | Evaluation of Fixation Achievable in Revision Total Knee Arthroplasty Implementing Latest-Generation Implant T NCT03276351 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | N/A |
| Unknown | Intrathecal Morphine and Fentanyl for Knee Arthroplasty NCT03365115 | Keimyung University Dongsan Medical Center | N/A |
| Unknown | Radiostereometric Analysis of Gap Balancing Versus Measured Resection for the Journey II Total Knee Replacemen NCT03290170 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | N/A |
| Completed | Zip Arthroplasty Patient Satisfaction Evaluation NCT03178266 | ZipLine Medical Inc. | — |
| Withdrawn | Effect of Downhill-uphill Walking Exercises on Functional Level and Muscle Strength in Patients With Knee Arth NCT03421938 | Dokuz Eylul University | N/A |
| Completed | Effects of Motor Imagery Intervention on Functional Recovery Following Total Knee Arthroplasty NCT03684148 | Science and Research Centre Koper | N/A |
| Completed | Quadriceps Sparing Versus Standard Total Knee Arthroplasty NCT03081663 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | N/A |
| Unknown | Gonyautoxins Local Periarticular Injection for Pain Management After Total Knee Arthroplasty NCT03025594 | maximiliano barahona vasquez | Phase 3 |
| Unknown | VEGA System® Study in the Total Knee Arthroplasty NCT02944409 | BBraun Medical SAS | — |
| Unknown | Non-Interventional Consecutive and Prospective Study of e.Motion® PS Pro Prosthesis in the Total Knee Artropla NCT02934802 | BBraun Medical SAS | — |
| Unknown | Functional Results With Attune Fixed Bearing Posterior Stabilized Knee Arthroplasty (A-16) NCT02791477 | Vestre Viken Hospital Trust | N/A |
| Completed | Fast-track Rehabilitation After Total Knee or Hip Arthroplasty NCT03035435 | Fondazione Don Carlo Gnocchi Onlus | — |
| Completed | Magnesium Sulfate in Adductor Canal Blocks NCT02581683 | Queen's University | Phase 4 |
| Completed | Postoperative Pain Management After Total Knee Arthroplasty NCT04344990 | University Hospital of Patras | N/A |
| Completed | Community Based Rehabilitation After Knee Arthroplasty NCT04867772 | University of Oxford | N/A |
| Completed | Operative Hemodynamic Optimization Using the Plethysmographic Variability Index During Orthopedic Surgery NCT02207296 | University Hospital, Caen | Phase 3 |
| Completed | The Efficiency of the PNF Method NCT04686071 | Jagiellonian University | N/A |
| Completed | Effect of Adductor Canal Nerve Block Compared to a Simulated Block on Quadriceps Strength Following Knee Arthr NCT02166710 | Centre hospitalier de l'Université de Montréal (CHUM) | N/A |
| Completed | Effects of Virtual Reality Rehabilitation in Patients With Total Knee Arthroplasty NCT02413996 | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | N/A |
| Completed | Cross Iron (Comparative Randomized Oral Versus Systemic IRON) NCT02496377 | University Hospital, Montpellier | N/A |
| Unknown | Evaluation of Motor Sparing Knee Block to Infiltration Analgesia for Pain Following Knee Arthroplasty NCT02540070 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Phase 3 |
| Completed | Performance of Flexible Self-adherent Absorbent Dressing Coated With a Soft Silicone Layer After Hip -,Knee- A NCT02771015 | University of Cologne | N/A |
| Completed | Progression of Health Related Quality of Life of Patients Waiting for Total Knee Arthroplasty NCT03492320 | Dr. Ho Ki Wai | — |
| Unknown | Substitution of the PCL in TKA With UC or PS Design NCT04679857 | Technische Universität Dresden | N/A |
| Completed | Clinical and Economic Comparison of Robot Assisted Versus Manual Knee Replacement NCT01705886 | Northwest Surgical Specialists, Vancouver | — |
| Terminated | Clinical Outcomes of Knee Replacement NCT01705366 | Northwest Surgical Specialists, Vancouver | — |
| Completed | A Comparison of US and Evoked Motor Response-guided Placement of Continuous Femoral Nerve Block Following TKA NCT03121976 | Sunnybrook Health Sciences Centre | N/A |
| Completed | Three Different Approaches for Ultrasound Guided Femoral Nerve Block for Patients Undergoing Total Knee Arthro NCT01763814 | Chicago Anesthesia Pain Specialists | N/A |
| Completed | Biomechanics of Gait Pattern Adaptation in Patients After Total Knee Arthroplasty NCT01412814 | Tel-Aviv Sourasky Medical Center | N/A |
| Completed | Comparison of Kinematics for Subjects Implanted With a PFC Sigma Rotating Platform or Fixed Bearing TC3 Prosth NCT01290640 | The University of Tennessee, Knoxville | — |
| Completed | The Efficacy of Adductor-Canal-Blockade on Pain and Morphine Consumption After Total Knee Arthroplasty NCT01261897 | Rigshospitalet, Denmark | Phase 4 |
| Unknown | Perioperative Analgesia After Knee Arthroplasty NCT01225484 | Landeskrankenhaus Feldbach | Phase 4 |
| Completed | The Efficacy of Adductor-Canal-Blockade on Pain and Morphine Consumption After Revision Knee Arthroplasty NCT01191593 | Rigshospitalet, Denmark | Phase 4 |
| Completed | Unipolar vs. Bipolar Hemostasis in Total Knee Arthroplasty: A Prospective Randomized Trial NCT01003080 | Montefiore Medical Center | N/A |
| Completed | Continuous Femoral Nerve Blockade and Readiness to Discharge Following Total Knee Arthroplasty NCT00803348 | University Health Network, Toronto | N/A |
| Unknown | Continuous Spinal Anesthesia Versus Combined Spinal Epidural Block NCT00616044 | Sao Jose do Rio Preto Medical School | N/A |
| Completed | Patient Understanding and Satisfaction in Informed Consent for Total Knee Arthroplasty NCT01582984 | jasvinder singh | N/A |
| Completed | Effect of Combined Use of Naloxone and Tramacet on Postop Analgesia in Elderly Patients Having Joint Replaceme NCT00679614 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Phase 3 |
| Completed | CT for Diagnosis of Implant Stability in Revision Arthroplasty NCT00367289 | Hadassah Medical Organization | — |
| Completed | Functional Performance of the Journey Deuce Bicompartmental Versus the Genesis II Total Knee System NCT01140815 | Anderson Orthopaedic Research Institute | Phase 4 |
| Active Not Recruiting | Hospital for Special Surgery Knee Arthroplasty Cohort NCT00454467 | Hospital for Special Surgery, New York | — |
| Completed | Active Versus Passive Motion Device Following Knee Replacement Surgery NCT02339831 | Brigham and Women's Hospital | N/A |
| Terminated | Computer-assisted Total Knee Arthroplasty (TKA) With Zimmer LPS Flex Knee System NCT00300326 | Queen's University | Phase 4 |
| Completed | Outcome Analysis of the Oxford Partial Knee Arthroplasty NCT00759616 | Zimmer Biomet | N/A |
| Withdrawn | Rehabilitation After Fast-track Total Knee Arthroplasty NCT01329081 | University of Aarhus | N/A |