| Not Yet Recruiting | Knee-hip Surgery Wait-list Support Program NCT06575621 | Nova Scotia Health Authority | N/A |
| Not Yet Recruiting | Extended Oral Tranexamic Acid After Primary Total Knee Arthroplasty NCT07494032 | NYU Langone Health | N/A |
| Withdrawn | Feasibility of an Analgesic Device Enabling Local Anesthetic Delivery and Neuromodulation After Knee Surgery NCT07336355 | University of California, San Diego | N/A |
| Not Yet Recruiting | Cryoneurolysis in Patients Awaiting Total Hip and Knee Arthroplasty NCT06942078 | University of Calgary | N/A |
| Not Yet Recruiting | Veterans Enhanced Recovery Using Integrative Treatments Around Surgery NCT06333938 | Durham VA Medical Center | Phase 4 |
| Recruiting | Physica TT Tibial Plate Follow up Study NCT06337123 | Limacorporate S.p.a | — |
| Recruiting | Femoral BMD Change Following Cemented or Cementless Total Knee Arthroplasty NCT06733597 | University of Wisconsin, Madison | N/A |
| Completed | Incidence and Microbial Profiles of Periprosthetic Joint Infection After Total Knee Arthroplasty in Obese vs N NCT07398742 | Bispebjerg Hospital | — |
| Not Yet Recruiting | Effect of Bupivacaine Liposomes or Bupivacaine for Femoral Triangle or Adductor Block on Analgesia After Total NCT06653621 | Huazhong University of Science and Technology | Phase 4 |
| Not Yet Recruiting | Influence of Different Prostheses on Postoperative Clinical Function in Total Knee Arthroplasty NCT06617819 | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | N/A |
| Recruiting | Mechanical Alignment vs Kalipered Kinematic Alignment Total Knee Arthroplasty NCT06617871 | Northwestern University | N/A |
| Not Yet Recruiting | Modified TIPS Block for Total Knee Arthroplasty NCT06539910 | Alexandria University | Phase 4 |
| Recruiting | Rate of Return to Sport After Total Knee Prosthesis: Comparison of Three Types of Prostheses NCT05928403 | GCS Ramsay Santé pour l'Enseignement et la Recherche | — |
| Recruiting | Virtual Rehabilitation Platform for Patients With Knee Prothesis NCT06720779 | Trak Health Solutions S.L. | N/A |
| Not Yet Recruiting | Non-Invasive Distractor During Knee Arthroscopy NCT06458816 | The Taylor Collaboration | N/A |
| Recruiting | Evaluation of Outcomes of the Triathlon Hinge Knee (THK) System NCT06379321 | The Cleveland Clinic | — |
| Unknown | ESPB vs iPACK+ACB in Total Knee Arthroplasty NCT06302218 | Poznan University of Medical Sciences | Phase 4 |
| Completed | NLR and PLR Levels Following IPACK Block in Knee Arthroplasty NCT06304298 | Poznan University of Medical Sciences | Phase 4 |
| Recruiting | Improving Total Knee Arthroplasty Dissatisfaction Through a Personalized Approach Focusing on PROMs Phenotypes NCT06298721 | The Cleveland Clinic | N/A |
| Unknown | A Pilot Feasibility Study Comparing Smartphone Home-based Rehabilitation Program Against the Usual Hospital an NCT06248034 | Singapore General Hospital | N/A |
| Completed | Ultrasound Guıded Adductor Canal Block vs Perıcapsular Nerve Group Block in Knee Artroplasty NCT06203483 | Bursa City Hospital | N/A |
| Recruiting | Persistent Post Surgical Pain After Total Knee Arthroplasty NCT06182059 | Policlinico di Monza SpA | N/A |
| Completed | Ultrasound-Guided Adductor Canal Block for Total Knee Arthroplasty Surgery NCT06084403 | Bursa City Hospital | N/A |
| Recruiting | Routine Use of Negative Pressure Wound Therapy THR TKR RCT NCT06181097 | Chinese University of Hong Kong | N/A |
| Completed | Low vs Standard Local Anesthetics Boluses for Continuous Adductor Canal Block in Total Knee Arthroplasty NCT06179628 | Chulalongkorn University | N/A |
| Unknown | TIPS Block vs Dual Subsartorial Block NCT06096584 | Alexandria University | Phase 4 |
| Recruiting | Post-Market Clinical Follow Up for Total Knee Arthroplasty System Madison NCT06120023 | Societe dEtude, de Recherche et de Fabrication | — |
| Active Not Recruiting | Motivational Feedback Following Total or Unicompartmental Knee Arthroplasty NCT06005623 | Odense University Hospital | N/A |
| Recruiting | l Investigation of Robotic-assisted TKA (RA-TKA) With Skywalker and Evolution Medial Pivot Knee (eMP Knee) NCT06969222 | Orthopaedic Department of General University Hospital of Laria | N/A |
| Unknown | Quality of Life, Functional Outcomes and Costs in Knee Arthroplasty NCT05882669 | I.M. Sechenov First Moscow State Medical University | — |
| Completed | Safety of Ibuprofen After Major Orthopaedic Surgeries NCT05575700 | Naestved Hospital | Phase 4 |
| Completed | Comparison Of The Analgesic Efficacy Of IPACK (Interspace Between The Popliteal Artery And Capsule Of The Post NCT06065878 | Cenk Gacemer | N/A |
| Completed | Function and Pain Following Knee Replacement NCT05478005 | University of Haifa | N/A |
| Unknown | Ligament Tension Measurement in Knee Arthroplasty NCT05583630 | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | — |
| Completed | The Effects of Frailty on Opioid Consumption NCT05445700 | Selcuk University | N/A |
| Completed | Preoperative Acupuncture for Total Knee or Hip Arthroplasty NCT06099223 | Hartford Hospital | N/A |
| Active Not Recruiting | Dorsal Root Ganglion Stimulation for the Treatment of Arthritic Knee Pain NCT05103527 | Kenneth B Chapman | N/A |
| Completed | Hemophilic Knee Arthropathy Virtual Reality NCT05802368 | Maged Basha | N/A |
| Completed | Comparison of Accuracy and Functional Outcome Between Robotic and Gyroscopic Assisted Surgery in Primary TKA NCT06321952 | Mahidol University | N/A |
| Completed | Core Stability Via Telerehabitation on TKA NCT06159205 | Burdur Mehmet Akif Ersoy University | N/A |
| Enrolling By Invitation | A Study to Evaluate Virtual Reality As Adjunct to Anesthesia During Orthopedic Surgery NCT05112302 | Mayo Clinic | — |
| Completed | The Impact of COVID-19 Pandemic on Hip and Knee Replacement NCT04883788 | Istituto Ortopedico Rizzoli | — |
| Completed | Iron and Vitamin Supplementation in Hip/Knee Surgery NCT04880499 | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | N/A |
| Active Not Recruiting | Determinants for Return to Work After Primary Knee Arthroplasty NCT04665180 | Universitaire Ziekenhuizen KU Leuven | N/A |
| Completed | Comparison of Early Whole Body Vibration and Progressive Resistance Training in Fast-Track Total Knee Arthropl NCT04831411 | Pamukkale University | N/A |
| Terminated | Virtual Reality for Post Operative Pain Management After Total Knee Arthroplasty NCT03665233 | Clinique Saint-Jean, Bruxelles | N/A |
| Completed | Pain Management After Adductor Canal Block for Total Knee Arthroplasty NCT06086483 | Poznan University of Medical Sciences | Phase 4 |
| Withdrawn | Pain Levels and Opioid Usage in Three Nerve Block Cohorts in Primary TKA NCT04292392 | University of Louisville | N/A |
| Completed | IPACK Block After Total Knee Arthroplasty NCT04295421 | University Tunis El Manar | N/A |
| Unknown | Defining the Optimal Location to Place an Adductor Canal Block NCT04298476 | Drexel University | N/A |
| Unknown | Medico-economic Interest of Single-use Ancillary Efficiency® in Fitting a GMK® Total Knee Arthroplasty (TKA) NCT04300439 | Nantes University Hospital | N/A |
| Unknown | Investigating the Effectiveness of Vibration Therapy on Sarcopenia in Osteoarthritis Knee Patients NCT03880344 | Chinese University of Hong Kong | N/A |
| Completed | SMART Dressing for Hypertrophic Scar Treatment Post-Total Knee/Hip Arthroplasty NCT03849274 | Chinese University of Hong Kong | EARLY_Phase 1 |
| Withdrawn | Ultrasound-Guided Adductor Canal Block for Total Knee Arthroplasty Surgery NCT04189640 | Medipol University | N/A |
| Completed | The Efficacy of Continuous Femoral Nerve Catheter Orifice Configuration for Postoperative Analgesia in Knee Ar NCT04202250 | Gulhane School of Medicine | N/A |
| Unknown | Radiostereometry in Knee Arthroplasty NCT04960111 | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | N/A |
| Unknown | Comparison of Radiological, Clinical, Functional Outcomes Between Anatomically Aligned Total Knee Arthroplasty NCT04183985 | The Catholic University of Korea | N/A |
| Completed | Effects of Virtual Reality in TKA Patients NCT05875324 | Kırklareli University | N/A |
| Withdrawn | ACB + IPACK Block With or Without Local Infiltration in RA-TKA NCT03840122 | University of Louisville | N/A |
| Terminated | Nickel Sensitivity NCT04058743 | Rush University Medical Center | N/A |
| Unknown | Effect of Vitamin D Status and Repletion on Postoperative Total Joint Arthroplasty Complications NCT04229368 | Brigham and Women's Hospital | N/A |
| Completed | Tourniquet vs. Short Time Tourniquet in Primary Robotic Assisted TKA NCT03942939 | University of Louisville | N/A |
| Completed | Improving Quality Based on the Joint Registry NCT04055103 | Leiden University Medical Center | N/A |
| Completed | Concepts for Analgosedation During Placement of Regional Anaesthesia Before Operations. NCT04026074 | Medical University of Graz | Phase 4 |
| Terminated | Hemoglobin Optimization to Prevent Transfusion and Adverse Events in Perioperative Patients With Iron Restrict NCT03528564 | Unity Health Toronto | Phase 2 |
| Completed | The Efficacy Of Ultrasound-Guided Adductor Canal Block for Arthroscopic Knee Surgery NCT04010916 | Medipol University | N/A |
| Completed | Comparison of Three Different Sitting Positions for Performing Combined Spinal-Epidural Anesthesia NCT03541798 | Diskapi Teaching and Research Hospital | N/A |
| Completed | Comparison of Balance and Fall Risk in Unilateral and Bilateral Total Knee Arthroplasty NCT04796519 | Pamukkale University | N/A |
| Completed | Optimization of a Fast-track Concept for Knee Joint Replacement NCT03920930 | Charite University, Berlin, Germany | N/A |
| Completed | Compressive Cryotherapy Versus Conventional Cryotherapy After Total Knee Arthroplasty NCT06037824 | Institut de Formation en Masso-Kinésithérapie Saint Michel | N/A |
| Completed | Iron Supplementation in Hip/Knee Surgery NCT04078880 | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | N/A |
| Completed | Cryoanalgesia to Prevent Acute and Chronic Pain Following Surgery: A Randomized, Double-Masked, Sham-Controlle NCT03578237 | University of California, San Diego | N/A |
| Completed | Comparison Between Two Operational Techniques for Total Knee Replacement NCT03605290 | HaEmek Medical Center, Israel | N/A |
| Unknown | Clinical Outcomes Between Tibial Preservation Bone Cut and Conventional Tibial Bone Cut Following Medial UKA NCT04419116 | Thammasat University | N/A |
| Completed | Laser + Cryo-thermal Therapy Following Total Knee Replacement Surgery NCT04183673 | Istituti Clinici Scientifici Maugeri SpA | N/A |
| Completed | Effect of IV Iron Isomaltoside on Postoperative Anemia in Total Knee Arthroplasty Patients NCT03470649 | Seoul National University Hospital | N/A |
| Unknown | Analysis of Influencing Factors and Construction of Prediction Models of Artificial Joint Replacement in China NCT05170321 | Xiangya Hospital of Central South University | — |
| Completed | Effectiveness of Reduced Frequency Physical Therapy in Total Knee Arthroplasty NCT03302832 | Campbell University, Incorporated | N/A |
| Completed | Effect of Pre-op Patient Education on Functional Outcomes After TKA NCT03230942 | University of the State of Santa Catarina | N/A |
| Completed | Effect of NLR and MPV on Early Postoperative Outcome in Lower Extremity Arthroplasty Operations NCT03148951 | Akdeniz University | — |
| Completed | Comparison of Regional Anesthesia Techniques After Total Knee Arthroplasty NCT03143738 | Medical University of Lublin | N/A |
| Terminated | Analyzing Challenging Clinical Discussions in Orthopaedics NCT03058393 | Duke University | N/A |
| Completed | Evaluation of a Fast-track Knee Arthroplasty Concept NCT03114306 | Charite University, Berlin, Germany | N/A |
| Completed | Adductor Canal Block With Periarticular Injection and IPACK (ACB/PAI/IPACK) Versus Periarticular Injection (PA NCT03094663 | Hospital for Special Surgery, New York | Phase 4 |
| Unknown | Opioid Requirements Post Discharge of Patients Having Total Knee Arthroplasty (TKA) NCT03106129 | Sunnybrook Health Sciences Centre | — |
| Completed | Pain and Impact of Chronic Pain on Function After Total Knee Replacements NCT03032679 | Tata Memorial Centre | — |
| Completed | Virtual Reality Rehabilitation in Patients With Total Knee Replacement NCT03454256 | IRCCS San Raffaele Roma | N/A |
| Active Not Recruiting | Persona Cohort Nordic Multicenter Study NCT03495232 | Zimmer Biomet | — |
| Completed | Patient Blood Management Program in Total Hip or Total Knee Arthroplasty NCT04137484 | University Hospital, Montpellier | — |
| Completed | Post-market Clinical Follow-up on the balanSys UNI Knee Prosthesis Implanted With a Spacer Block Surgical Tech NCT04598568 | Mathys Ltd Bettlach | — |
| Completed | Fibrin Glue or Tranexamic Acid for Total Knee Arthroplasty NCT01306370 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | Phase 3 |
| Completed | Robotic-Assisted Versus Conventional Total Knee Arthroplasty(TKA) NCT03659318 | Ewha Womans University | Phase 4 |