NCT06182059

Persistent Post Surgical Pain After Total Knee Arthroplasty

Enhanced Recovery After Surgery and Total Knee Replacement: A Prospective, Randomized Study on the Rule of Peripheral Nerve Blocks on Persistent Postoperative Pain Six Months After Surgery

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 436 (estimated)
• Sponsor: Policlinico di Monza SpA · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

Patients undergone total knee replacement are randomized to receive a "fast track" regional anesthesia protocol or a "traditional" regional anesthesia continuous infusion by both a femoral and sciatic catheter to assess if this latter technique may reduce persistent postoperative pain six months after surgery

Detailed description

Patients undergone to primary total knee replacement with spinal anesthesia are randomized to receive a continuous adductor canal block infusion + an ipack block or a continuous femoral nerve block + a continuous sciatic nerve block just at the end of surgery. Both group will receive a multimodal analgesia with paracetamol, ketorolac, desametasone and morphine as a rescue.

Conditions

• Knee Arthropathy

Interventions

Type	Name	Description
PROCEDURE	continuous peripheral nerve block	continuous regional anesthesia in total knee replacement

Timeline

• Start date: 2024-01-12
• Primary completion: 2027-01-31
• Completion: 2027-07-31
• First posted: 2023-12-26
• Last updated: 2025-06-03

Locations

1 site across 1 country: Italy