| Not Yet Recruiting | Paclitaxel and Pegylated Liposomal Doxorubicin for Treatment of HIV-related Kaposi Sarcoma NCT05411237 | AIDS Malignancy Consortium | Phase 3 |
| Not Yet Recruiting | A Study of Propranolol to Treat Kaposi Sarcoma NCT05797662 | AIDS Malignancy Consortium | Phase 2 |
| Not Yet Recruiting | Precision Imaging to Evaluate Kaposi Sarcoma NCT06898203 | Washington University School of Medicine | N/A |
| Recruiting | Recombinant Glycosylated Human Interleukin-7 (CYT107) for the Treatment of Kaposi Sarcoma in Participants With NCT07308886 | National Cancer Institute (NCI) | Phase 2 |
| Recruiting | Propranolol for the Treatment of Kaposi Sarcoma in Adults NCT06445166 | Washington University School of Medicine | Phase 2 |
| Recruiting | Precision Imaging to Evaluate Kaposi Sarcoma (PRIME-KS): A Device Feasibility Trial NCT06751355 | Washington University School of Medicine | — |
| Recruiting | Agnostic Therapy in Rare Solid Tumors NCT06638931 | Instituto do Cancer do Estado de São Paulo | Phase 2 |
| Recruiting | Natural History Study of Kaposi Sarcoma NCT06375122 | National Cancer Institute (NCI) | — |
| Recruiting | AYAHIV Role-based Responsibilities for Oncology-focused Workforce (ARROW) NCT06004011 | Implenomics | N/A |
| Withdrawn | Pembrolizumab Plus Lenvatinib in Previously Treated Classic Kaposi Sarcoma NCT05846724 | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | Phase 2 |
| Recruiting | Trial of Ixazomib for Kaposi Sarcoma NCT04305691 | AIDS Malignancy Consortium | Phase 2 |
| Recruiting | Collecting Blood and Tissue Sample Donations for Research for HIV/AIDS-Related Cancers NCT05663502 | AIDS Malignancy Consortium | — |
| Recruiting | A Study of MQ710 With and Without Pembrolizumab in People With Solid Tumor Cancer NCT05859074 | Memorial Sloan Kettering Cancer Center | Phase 1 |
| Active Not Recruiting | Kaposi Sarcoma Chemotherapy and Research (KS-CARE) NCT06480773 | UNC Lineberger Comprehensive Cancer Center | — |
| Unknown | L19IL2/L19TNF in Skin Cancer Patients NCT05329792 | Philogen S.p.A. | Phase 2 |
| Terminated | NT-I7 for Kaposi Sarcoma in Patients With or Without HIV NCT04893018 | Fred Hutchinson Cancer Center | Phase 1 |
| Recruiting | Pomalidomide and Nivolumab in People With Virus-Associated Malignancies With or Without HIV NCT04902443 | National Cancer Institute (NCI) | Phase 1 |
| Recruiting | Abemaciclib in Patients With HIV-associated and HIV-negative Kaposi Sarcoma NCT04941274 | National Cancer Institute (NCI) | Phase 1 / Phase 2 |
| Recruiting | HHV8 and Solid Organ Transplantation NCT05081141 | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | — |
| Active Not Recruiting | Assessment of Bone Mineral Density in People Living With HIV and KSHV Associated Malignancies: A Retrospective NCT04742387 | National Cancer Institute (NCI) | — |
| Unknown | Phase II Multicenter Study of Talimogene Laherparepvec in Classic or Endemic Kaposi Sarcoma NCT04065152 | Assistance Publique - Hôpitaux de Paris | Phase 2 |
| Recruiting | A Study of sEphB4-HSA in Kaposi Sarcoma NCT03993106 | Vasgene Therapeutics, Inc | Phase 2 |
| Recruiting | PDS01ADC Monotherapy and in Combination With M7824 in Advanced Kaposi Sarcoma NCT04303117 | National Cancer Institute (NCI) | Phase 1 / Phase 2 |
| Unknown | Phase II Multicentric Study of Pembrolizumab in Classic or Endemic Kaposi's Sarcoma NCT03469804 | Assistance Publique - Hôpitaux de Paris | Phase 2 |
| Completed | Intra-lesional Nivolumab Therapy for Limited Cutaneous Kaposi Sarcoma NCT03316274 | University of California, San Francisco | EARLY_Phase 1 |
| Completed | Compression Therapy for Leg Ulcers and Kaposi Sarcoma in Western Kenya NCT03404297 | Indiana University | N/A |
| Completed | An Evaluation of Tc 99m Tilmanocept by Intravenous (IV) and Subcutaneous (SC) Injection in Kaposi Sarcoma (KS) NCT03157167 | Navidea Biopharmaceuticals | Phase 1 |
| Completed | Smartphone Confocal Microscopy for Diagnosing Kaposi's Sarcoma NCT03050788 | Massachusetts General Hospital | N/A |
| Completed | Investigating Chemotherapy Treatments, Response and Subsets of HIV-associated Kaposi Sarcoma in Malawi NCT03160183 | UNC Lineberger Comprehensive Cancer Center | — |
| Completed | Testing the Addition of an Experimental Medication MK-3475 (Pembrolizumab) to Usual Anti-Retroviral Medication NCT02595866 | National Cancer Institute (NCI) | Phase 1 |
| Active Not Recruiting | Pomalidomide in Combination With Liposomal Doxorubicin in People With Advanced or Refractory Kaposi Sarcoma NCT02659930 | National Cancer Institute (NCI) | Phase 1 |
| Terminated | Nivolumab and Ipilimumab in Treating Patients With HIV Associated Relapsed or Refractory Classical Hodgkin Lym NCT02408861 | National Cancer Institute (NCI) | Phase 1 |
| Completed | Impact of Valganciclovir on Severe IRIS-Kaposi Sarcoma Mortality: an Open-label, Parallel, Randomized Controll NCT03296553 | National Institute of Cancerología | Phase 2 |
| Terminated | Nelfinavir for the Treatment of Gammaherpesvirus-Related Tumors NCT02080416 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | EARLY_Phase 1 |
| Withdrawn | Early Phase Evaluation of ABC294640 in Patients With Refractory/Relapsed Diffuse Large B-cell Lymphoma or Kapo NCT02229981 | RedHill Biopharma Limited | Phase 1 / Phase 2 |
| Completed | Pomalidomide for Kaposi Sarcoma in People With or Without HIV NCT01495598 | National Cancer Institute (NCI) | Phase 1 / Phase 2 |
| Terminated | A Phase II Study With Tumor Molecular Pharmacodynamic (MPD) Evaluation of Oral mTOR-inhibitor Everolimus (RAD0 NCT01412515 | Institut National de la Santé Et de la Recherche Médicale, France | Phase 2 |
| Completed | Development of Serologic Assays for Human Herpes Virus-8 NCT00395278 | National Institutes of Health Clinical Center (CC) | — |