| Not Yet Recruiting | Effects of Extracorporeal Circulation Techniques on Cerebral Perfusion in CABG Surgery NCT07420738 | Kartal Kosuyolu High Speciality Training and Research Hospital | — |
| Recruiting | Optic Nerve Ultrasound for Assessing Cerebral Inflammation and Intracranial Hypertension in Cerebral Pathologi NCT07332234 | Spitalul Clinic de Boli Infecțioase și tropicale "Dr. Victor Babeș" | — |
| Not Yet Recruiting | Effectiveness of Surgical Procedures for Acute Cranial Expansion in Traumatic Brain Injury NCT06776614 | Meditech Foundation | — |
| Not Yet Recruiting | Security and Effectiveness Assessment of Locking Systems in Ventriculostomy for Traumatic Brain Injury NCT06772155 | Meditech Foundation | — |
| Recruiting | Ocular Characteristics in Patients With Craniosynostosis NCT06928727 | Centre Hospitalier Universitaire, Amiens | — |
| Recruiting | Study SOLACE SEPSIS NCT06634069 | University Hospital Pilsen | Phase 2 |
| Suspended | Ketamine for Sedation in Severe Traumatic Brain Injury NCT06429657 | Henry M. Jackson Foundation for the Advancement of Military Medicine | Phase 4 |
| Recruiting | External Lumbar Drainage to Reduce ICP in Severe TBI: a Phase 1 Clinical Trial NCT05889650 | Brain Trauma Foundation | N/A |
| Recruiting | Lidocaine, Dexmedetomidine, Esmolol and Magnesium Effect on Optic Nerve Sheath Diameter After Laryngoscopy NCT06254534 | Haseki Training and Research Hospital | N/A |
| Recruiting | Intracranial PrEssure Time dOse (ImPETO) NCT04459806 | University of Milano Bicocca | — |
| Completed | Optic Nerve Sheath Diameter in Low-flow and Normal-flow Rate Anesthesia NCT05946200 | Konya City Hospital | N/A |
| Unknown | Non-invasive ONSD-based Neuromonitoring in a Neurointensive Care Setting NCT05818371 | University Hospital Tuebingen | N/A |
| Completed | Investigating CBF and ICP Using DCS NCT06039098 | Queen Mary University of London | — |
| Completed | Bleeding Intracerebral Hemorrhage With Early Invasive Intracranial Pressure Monitoring Trial NCT05593380 | Xiangya Hospital of Central South University | N/A |
| Recruiting | Non Invasive Measurement With Trans Cranial Doppler Versus Invasive Measurement in Pediatric Age NCT05340062 | Azienda Ospedaliera di Padova | — |
| Completed | The Effect of Caudal Block on Optic Nerve Sheath Diameter in Pediatric Patients NCT05216211 | Ataturk University | N/A |
| Unknown | CSF Biomarkers in Idiopathic Intracranial Hypertension NCT05647837 | Assiut University | N/A |
| Completed | Optic Nerve Sheath Diameter: A Non-Invasive Indicator of Intracranial Pressure in the Intensive Care Unit Moni NCT06367868 | Istanbul University - Cerrahpasa | N/A |
| Unknown | Comparison of the Effects of Deep and Moderate Neuromuscular Blockade on Optic Nerve Sheath Diameter NCT04211064 | Bezmialem Vakif University | N/A |
| Completed | Augmented Reality-Assisted Neurosurgical Drain Placement NCT06571539 | Universitair Ziekenhuis Brussel | N/A |
| Unknown | Timing of Invasive Intracranial Pressure Monitoring Between Neurosurgeons and Intensive Care Physicians NCT05045105 | Università degli Studi di Brescia | — |
| Withdrawn | Coagulation Activation by Hyperosmolar Agents in Intracranial Hypertension NCT03409237 | Neuromed IRCCS | — |
| Completed | Sodium Lactate and Brain Relaxation (LSD) NCT04488874 | Centre Hospitalier Universitaire de Besancon | Phase 3 |
| Completed | Cerebral Compliance Impairment in COVID-19 NCT04429477 | University of Sao Paulo | — |
| Active Not Recruiting | Assessment of Venous Drainage in Idiopathic Intracranial Hypertension NCT04115553 | Centre Hospitalier Universitaire, Amiens | N/A |
| Completed | A Non-invasive Intracranial Pressure (nICP) Monitoring System NCT05632302 | Crainio Ltda | N/A |
| Completed | Optical Nerve Sheath Changes During Head Down Laparoscopy NCT03957837 | ASST Fatebenefratelli Sacco | — |
| Terminated | Safety of Optimal PEEP in NSICU Patients NCT03862027 | University of North Carolina, Chapel Hill | N/A |
| Unknown | Validation of Non-Invasive Intracranial Pressure (ICP) Monitoring Device NCT03865576 | Boston Neurosciences | — |
| Completed | Brain Skull Deformation as a Non-invasive Intracranial Pressure (ICP) Measure NCT05121155 | Federal University of São Paulo | — |
| Completed | Optic Nerve Sonography to Monitor Intracranial Pressure After Ischemic sTrokE - The ONSITE Study NCT06939114 | University of Zurich | — |
| Unknown | Brain Ultrasound in the Weaning of External Ventricular Leads NCT03531723 | University Hospital, Toulouse | — |
| Unknown | Endovascular Stenting Treatment for Patients With Internal Jugular Vein Stenosis NCT03373292 | Capital Medical University | Phase 1 |
| Terminated | Clinical Efficacy of a Non-Invasive Measure of Intracranial Pressure NCT03212976 | University of Miami | N/A |
| Unknown | Invasive Versus Non Invasive Measurement of Intracranial Pressure in Brain Injury Trial (IMPRESSIT) NCT02322970 | Università degli Studi di Brescia | — |
| Unknown | A Novel Non-invasive Technique of Cerebral Compliance and Auto-regulation Assessment NCT03144219 | University of Sao Paulo | — |
| Completed | Optic Nerve Sheath Diameter in Retrobulbar Ultrasound as a Surrogate Measure for Intracranial Pressure Before NCT03634176 | Hospital Dr. Miguel Pérez Carreño | — |
| Completed | Our Anesthesia Experience During MRI Scan NCT03123302 | Akdeniz University | — |
| Completed | Sonography of the Optic Nerve Sheath Diameter for Detection of Elevated Intracranial Pressure (ICP) NCT03529370 | National Heart Institute, Egypt | — |
| Withdrawn | Non-invasive Intracranial Pressure (ICP) Monitoring in Pediatric Patients NCT02695264 | HeadSense Medical | N/A |
| Withdrawn | Optic Nerve Sheath Diameter and Intracranial Pressure (ICP) in Children NCT02507063 | Anna Rominger | — |
| Withdrawn | Dexmedetomidine on Optic Nerve Sheath Diameter NCT02753205 | Gachon University Gil Medical Center | N/A |
| Completed | Intracranial Pressure and Brain Function: Effects of Head Down Tilt Upon Brain Perfusion and Cognitive Perform NCT02976168 | DLR German Aerospace Center | N/A |
| Terminated | Mechanical Ventilation in Severe Brain Injury: The Effect of Positive End Expiratory Pressure on Intracranial NCT02680704 | Beth Israel Deaconess Medical Center | N/A |
| Completed | Optic Nerve Ultrasound in Severe Traumatic Injury NCT02618226 | University of Michigan | — |
| Suspended | An Evaluation of Non-Invasive ICP Monitoring in Patients Undergoing Invasive ICP Monitoring Via an Intraparenc NCT02773888 | HeadSense Medical | N/A |
| Unknown | Comparison of the Non-invasive ICP HeadSense Monitor vs Lumbar CSF Pressure Measurement NCT02773901 | HeadSense Medical | N/A |
| Withdrawn | Optic Nerve Head Quantification While Reducing Elevated Intracranial Pressure NCT02558309 | NYU Langone Health | — |
| Completed | Intracranial Pressure After Decompressive Craniectomy NCT03364634 | Rigshospitalet, Denmark | — |
| Completed | Automated Measurement of Optic Nerve Sheath Diameter NCT02786706 | University of Michigan | — |
| Unknown | Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of NCT02404779 | University Hospital, Clermont-Ferrand | Phase 4 |
| Completed | The Use of Near Infrared Spectroscopy (NIRS) to Estimate Intracranial Pressure (ICP) NCT01850069 | University of Virginia | — |
| Completed | Prospective Evaluation of the Non-invasive ICP HeadSense Monitor in TBI Patients Undergoing Invasive ICP Monit NCT02773862 | HeadSense Medical | N/A |
| Completed | Development and Evaluation of the ICP Waveform Tracing Capabilities and Safety of HS-1000 Device NCT02772471 | HeadSense Medical | N/A |
| Completed | Influencing Factors of Intracranial Hypertension in Patients With Bilateral Transverse Sinus Stenosis NCT04492332 | Capital Medical University | N/A |
| Terminated | Intraventricular Drain Insertion: Comparison of Ultrasound-guided and Landmark-based Puncture of the Ventricul NCT01973764 | Insel Gruppe AG, University Hospital Bern | N/A |
| Unknown | Clinical Value of Noninvasive Intracranial Pressure Measurement NCT02130219 | Lithuanian University of Health Sciences | Phase 2 / Phase 3 |
| Completed | A Continuous, Non-Invasive, Real-time Method for Estimating and Predicting Intracranial Hypertension NCT01448681 | University of Colorado, Denver | — |
| Unknown | Evaluation the Intracranial Volume Pressure Response in Increased Intracranial Pressure NCT01126658 | Chang Gung Memorial Hospital | — |
| Terminated | Comparison of 2 Doses of Mannitol on Post Traumatic Intracranial Hypertension and Cerebral Monitoring NCT00795587 | University Hospital, Grenoble | Phase 4 |
| Completed | Automated Chest Physiotherapy to Improve Outcomes in Neuro NCT00571623 | Duke University | — |
| Completed | The Effect of Prometheus (R) Liver Support Dialysis on Cerebral Metabolism in Acute Liver Failure NCT00655304 | Rigshospitalet, Denmark | N/A |
| Completed | 3-D Transcranial Ultrasound Analysis Study NCT00239525 | Duke University | N/A |
| Unknown | Effect of Ketamine (Ketalar) on Intracranial Pressure NCT00437814 | Rambam Health Care Campus | N/A |
| Terminated | Cerebral Hemodynamic Effects of Hypertonic Solutions in Severely Head-Injured Patients NCT00125229 | The University of Texas Health Science Center at San Antonio | — |
| Completed | Hypothermia to Prevent High Intracranial Pressure in Patients With Acute Liver Failure NCT00670124 | Rigshospitalet, Denmark | N/A |
| Completed | Impact of Ventricular Catheter Used With Antimicrobial Agents on Patients With a Ventricular Catheter NCT00286104 | Chinese University of Hong Kong | Phase 3 |
| Terminated | Sodium-Lactate and Traumatic Brain Injury NCT00319345 | Institut d'Anesthesiologie des Alpes Maritimes | Phase 2 / Phase 3 |
| Completed | Mannitol Versus Hypertonic Saline Solution in the Treatment of Elevated Intracranial Pressure NCT00447018 | University Hospital, Grenoble | Phase 4 |