NCT00795587

Comparison of 2 Doses of Mannitol on Post Traumatic Intracranial Hypertension and Cerebral Monitoring

Compared Effects of 2 Doses of Mannitol on Post Traumatic Intracranial Hypertension

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 3 (actual)
• Sponsor: University Hospital, Grenoble · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Will an increase of the dose of mannitol improve the effects on neuromonitoring in patients suffering intracranial hypertension following traumatic brain injury?

Detailed description

traumatic brain injury intracranial hypertension 0,4 g/ kg vs 0,8 g/ kg (randomized) on 20 minutes monitoring: ICP, transcranial doppler, brain pO2, MAP, HR, diuresis, biology duration: 2 hours

Conditions

• Traumatic Brain Injury
• Intracranial Hypertension

Interventions

Type	Name	Description
DRUG	variation of mannitol dose	in case of intracranial hypertension up to 20 mmHg lasting more than 10 minutes and without nociceptive stimulation or systemic instability: injection of either 0.4 g/ kg or 0.8 g/ kg of mannitol 20% (randomized) on 20 minutes, with monitoring of neurologic, systemic and biologic datas during 120 minutes

Timeline

• Start date: 2008-10-01
• Primary completion: 2011-08-01
• Completion: 2011-08-01
• First posted: 2008-11-21
• Last updated: 2012-11-08

Locations

1 site across 1 country: France