NCT02753205

Dexmedetomidine on Optic Nerve Sheath Diameter

Effect of Dexmedetomidine on Optic Nerve Sheath Diameter During Laparoscopic Anterior Resection

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Gachon University Gil Medical Center · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Dexmedetomidine, might attenuate the sympathetic activation and contribute to stable hemodynamics. The investigator hypothesized that continuous infusion of dexmedetomidine during laparoscopic lower abdominal surgery, might help to attenuate the increment of intracranial pressure and the investigator would observe the optic nerve sheath diameter using ultrasonography.

Detailed description

Laparoscopic lower abdominal surgery requires the Trendelenburg position with pneumoperitoneum for a prolonged time, but this can cause significant increase in intracranial pressure. Dexmedetomidine, a selective alpha2 receptor agonist might attenuate the sympathetic activation and contribute to stable hemodynamics. The investigator hypothesized that continuous infusion of dexmedetomidine during laparoscopic lower abdominal surgery, might help to attenuate the increment of intracranial pressure and the investigator would observe the optic nerve sheath diameter using ultrasonography.

Conditions

• Intracranial Hypertension

Interventions

Type	Name	Description
DRUG	Dexmedetomidine	infusion of dexmedetomidine 0.5ug/kg/h for 10 min and after that, infusion of dexmedetomidine 0.4ug/kg/h until the end of surgery
DRUG	normal saline	infusion of normal saline

Timeline

• Start date: 2016-04-01
• Primary completion: 2018-04-01
• Completion: 2018-04-01
• First posted: 2016-04-27
• Last updated: 2016-11-10