| Recruiting | Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE) NCT07322133 | University of California, Davis | Phase 4 |
| Not Yet Recruiting | Inhaled Nitric Oxide in Severe Obesity NCT06675435 | Massachusetts General Hospital | N/A |
| Not Yet Recruiting | Optimisation of High Flow Oxygen Therapy Settings During Hypoxaemic Respiratory Distress Based on Non-contact NCT06819644 | University Hospital, Brest | Phase 3 |
| Recruiting | PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients NCT06716463 | Unity Health Toronto | — |
| Active Not Recruiting | Asymmetrical HFNCO vs Standard HFNCO Post Cardiac Surgery Patients NCT06521489 | National and Kapodistrian University of Athens | N/A |
| Completed | The Role of Lung and Diaphragm Ultrasonography in Predicting Clinical Progression in Hypoxemic Respiratory Fai NCT06706830 | Simge Evren | — |
| Completed | Utility of Defining ARDS and Past and Current Definitions of ARDS NCT06159465 | NMC Specialty Hospital | — |
| Unknown | Optimal Timing and Failure Prediction of High Flow Nasal Cannula Oxygen Therapy in Emergency Department: Prosp NCT06064409 | Yonsei University | — |
| Completed | In Line Aerosol Nebulization With High Flow NCT05880836 | University of California, Los Angeles | N/A |
| Unknown | NIV-FOB, HFNC-FOB- Comparison of Methods NCT05655026 | Medical University of Silesia | N/A |
| Unknown | The Effect of Non-invasive Respiratory Support on Outcome and Its Risks in Severe Acute Respiratory Syndrome C NCT06033560 | Amsterdam UMC, location VUmc | — |
| Terminated | Correlation of Peak Tidal Inspiratory Flow Measured Before and After Extubation in Adult Patients With Hypoxem NCT04971148 | Rush University Medical Center | N/A |
| Recruiting | Helmet NIV vs. CPAP vs. High-flow Nasal Oxygen in Hypoxemic Respiratory Failure NCT05089695 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Active Not Recruiting | Feasibility and Efficacy of Automated Lateral Decubitus Therapy in Hypoxemic Respiratory Failure NCT06698913 | University of Sao Paulo General Hospital | N/A |
| Withdrawn | COVIDNOCHE Trial (HFNO Versus CPAP Helmet) in COVID-19 Pneumonia NCT04381923 | University of Pennsylvania | N/A |
| Unknown | Impact and Sequelae of High Ventilatory Drive in Critically Ill COVID-19 Patients NCT05363332 | Corporacion Parc Tauli | — |
| Unknown | Clinical Relevance of Nicardipine Induced Hypoxemia in the Intensive Care Unit NCT05155202 | University Hospital, Caen | — |
| Completed | Flow Rates of High-flow Nasal Cannula and Extubation Outcome NCT04934163 | National Taiwan University Hospital | N/A |
| Active Not Recruiting | Preductal Oxygen Saturation Target in Term and Late Preterm Neonates With Hypoxemic Respiratory Failure or Pul NCT04938167 | University of California, Davis | N/A |
| Completed | Continuous Flow Ventilation With the Ventijet System in Acute Respiratory Distress Syndrome: a First-in-Human NCT07121257 | Hospital del Mar | N/A |
| Completed | Awake Prone Positioning in COVID-19 Suspects With Hypoxemic Respiratory Failure NCT04853979 | Hamad Medical Corporation | N/A |
| Withdrawn | P-Co-Li (Pulmonary Covid-19 Study) NCT04782700 | Northwell Health | N/A |
| Active Not Recruiting | Identification and Treatment of Hypoxemic Respiratory Failure and ARDS With Protection, Paralysis, and Proning NCT04744298 | University of Calgary | N/A |
| Unknown | Effect on paO2 of Adding an Aerosol Mask Above the Nasal Canulas NCT04715854 | Laboratory of Movement, Condorcet, Tournai, Belgium | N/A |
| Unknown | NHF vs. COT in Hypoxemic Pandemic Viral Illness NCT04750408 | Jens Bräunlich | N/A |
| Completed | Standard Oxygen Versus High Flow Nasal Cannula Oxygen Therapy in Patients With Acute Hypoxemic Respiratory Fai NCT04468126 | Poitiers University Hospital | N/A |
| Withdrawn | iNOPulse for COVID-19 NCT04398290 | Roger Alvarez | Phase 2 |
| Unknown | CORONA (COvid pRONe hypoxemiA): Prone Positioning for Hypoxemic COVID-19 Patients With Do-not-intubate Goals NCT04402879 | University of Calgary | N/A |
| Completed | Efficacy of Intravenous Almitrine in Reducing the Need for Mechanical Ventilation in Patients With Hypoxemic A NCT04357457 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Completed | HFNC and Prone Positioning in Awake Patients With Severe COVID-19 NCT04982341 | Hôpital Universitaire Fattouma Bourguiba | — |
| Completed | Handling Oxygenation Targets in COVID-19 NCT04425031 | Aalborg University Hospital | Phase 4 |
| Terminated | Pemziviptadil (PB1046), a Long-acting, Sustained Release Human VIP Analogue, Intended to Provide Clinical Impr NCT04433546 | PhaseBio Pharmaceuticals Inc. | Phase 2 |
| Completed | Inhaled Iloprost for Suspected COVID-19 Respiratory Failure NCT04445246 | Hamad Medical Corporation | Phase 2 |
| Completed | Use of Combined Prone Positioning and High-Flow Nasal Cannula, and Non-invasive Positive Pressure Ventilation NCT04694638 | Mayo Clinic | N/A |
| Unknown | Endothelial Dysfunction in Covid-19 NCT04830683 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | — |
| Completed | Automatic Oxygen Titration With O2matic® to Patients Admitted With COVID-19 and Hypoxemic Respiratory Failure NCT04565106 | Hvidovre University Hospital | — |
| Completed | Extended Prone Position Duration COVID-19-related ARDS: a Retrospective Study NCT05124197 | Hôpital Louis Mourier | — |
| Completed | Prone Position During ECMO in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Hypoxaemic Patient NCT04995289 | Mohammed VI University Hospital | — |
| Completed | Automated Oxygen Control by O2matic to Patients Admitted With Acute Hypoxemia NCT04079465 | Hvidovre University Hospital | N/A |
| Completed | Treatment of Hypoxemic Respiratory Failure and ARDS With Protection, Paralysis, and Proning (TheraPPP) Pathway NCT04070053 | University of Calgary | N/A |
| Completed | Assessing Lung Inhomogeneity During Ventilation for Acute Hypoxemic Respiratory Failure NCT03589482 | University Health Network, Toronto | N/A |
| Completed | Evaluation of Conventional Non-invasive Mechanical Ventilation (NIV) Versus an Automatic Ventilation Mode. NCT03872167 | Hospital Clinic of Barcelona | N/A |
| Unknown | A Pilot Study Comparing Oxygen Delivery Via Helmet Interface Versus High Flow Nasal Cannula NCT04035460 | Baystate Medical Center | N/A |
| Completed | High Flow Oxygen Therapy Versus Conventional Oxygen Therapy in Cardiac Surgery Patients NCT03282552 | National and Kapodistrian University of Athens | N/A |
| Completed | Milrinone in Congenital Diaphragmatic Hernia NCT02951130 | NICHD Neonatal Research Network | Phase 2 |
| Completed | Impact of High-level Oxygen Therapy on the Reconditioning of Type I Hypoxemic Respiratory Insufficiency Patien NCT04022603 | Dr David DE BELS | N/A |
| Completed | Handling Oxygenation Targets in the Intensive Care Unit NCT03174002 | Aalborg University Hospital | Phase 4 |
| Unknown | PEEP Levels Selected by PEEP Titration and PEEP Levels Routinely Used in Post-operative Cardiac Patients With NCT02056977 | University of Sao Paulo General Hospital | N/A |
| Unknown | Comparison of Central Venous Oxygen Saturation Measurements by Non-invasive Mespere Venous Oximeter and Centra NCT01788956 | Mespere Lifesciences Inc. | — |
| Completed | Bi-PAP vs Sham Bi-PAP on Pulmonary Function in Morbidly Obese Patients After Bariatric Surgery NCT03438383 | Evangelismos Hospital | N/A |