| Recruiting | Kisspeptin Administration Subcutaneously to Patients With Hypothalamic Amenorrhea NCT07224438 | Stephanie B. Seminara, MD | Phase 2 |
| Completed | Opioid Antagonism in Hypogonadotropic Hypogonadism NCT04975334 | Stephanie B. Seminara, MD | Phase 1 |
| Not Yet Recruiting | Growing up With the Young Endocrine Support System (YESS!) NCT04252001 | dr. Laura C. G. de Graaff-Herder | N/A |
| Recruiting | Assessment of Endometrial Thickness Among Adolescent and Young Adult Patients on Estrogen Replacement Therapy NCT06357442 | University of Colorado, Denver | — |
| Unknown | Low Energy Availability and Pituitary Function (LEAP Study) NCT05808647 | University of Colorado, Denver | N/A |
| Recruiting | Kisspeptin Administration Subcutaneously to Patients With IHH NCT05896293 | Stephanie B. Seminara, MD | Phase 2 |
| Completed | Kisspeptin Administration Subcutaneously to Patients With Reproductive Disorders NCT05633966 | Stephanie B. Seminara, MD | Phase 1 |
| Unknown | Efficacy of Prolonged GnRH Test in Male Adolescents With Postoperative HH NCT05184374 | Huashan Hospital | N/A |
| Terminated | A Randomized, Double-blinded, Clinical, Placebo-controlled Trial on the Effects of Therapy With Letrozole and NCT05205837 | Rigshospitalet, Denmark | Phase 4 |
| Active Not Recruiting | The Molecular Basis of Inherited Reproductive Disorders NCT05971836 | Stephanie B. Seminara, MD | — |
| Completed | A Study of the Effect of Testosterone Replacement Therapy on Blood Pressure in Adult Male Participants With Hy NCT04456296 | Endo Pharmaceuticals | Phase 4 |
| Completed | Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic Hypogonadism NCT04648969 | Stephanie B. Seminara, MD | Phase 2 |
| Completed | Hypothalamic-pituitary Dysfunction in Diabetes NCT05752591 | Istituto Auxologico Italiano | — |
| Completed | Efficacy and Safety of Corifollitropin Alfa (MK-8962) in Combination With Human Chorionic Gonadotropin (hCG) i NCT03019575 | Organon and Co | Phase 3 |
| Completed | A 6 Month Safety Extension Study of MBGS205 NCT02908074 | Mereo BioPharma | Phase 2 |
| Unknown | Human Menopausal Gonadotropin Combining With Human Chorionic Gonadotropin Treat Congenital Hypogonadotropic Hy NCT02880280 | Beijing Children's Hospital | Phase 4 |
| Completed | Safety and Efficacy of BGS649 in Male Obese Subjects With Hypogonadotropic Hypogonadism NCT02730169 | Mereo BioPharma | Phase 2 |
| Unknown | Efficacy of Pulsatile GnRH Therapy on Male Patients With Pituitary Stalk Interruption Syndrome NCT02705014 | Peking Union Medical College Hospital | N/A |
| Terminated | A Phase 2a Pharmacodynamic Study of TAK-448 in Participants With Hypogonadotropic Hypogonadism NCT02369796 | Takeda | Phase 2 |
| Completed | Effect of Intranasal Insulin on LH Concentrations in Man NCT02154477 | Texas Tech University Health Sciences Center | Phase 1 / Phase 2 |
| Completed | Neuropeptides in Human Reproduction NCT01952782 | Massachusetts General Hospital | Phase 1 |
| Completed | Bioequivalence Study of Test and Reference Testosterone Topical Gel, 1.62% Metered Pump in Testosterone Defici NCT02110368 | Amneal Pharmaceuticals, LLC | Phase 3 |
| Completed | Kisspeptin in the Evaluation of Delayed Puberty NCT01438034 | Massachusetts General Hospital | Phase 1 |
| Completed | A Study of the Efficacy and Safety of Corifollitropin Alfa (MK-8962) in Combination With Human Chorionic Gonad NCT01709331 | Organon and Co | Phase 3 |
| Completed | Bone Mineral Markers in Hypogonadism NCT02062307 | Gulhane School of Medicine | — |
| Recruiting | Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and/or Palate NCT01601171 | Centre Hospitalier Universitaire Vaudois | — |
| Completed | Elucidating Kisspeptin Physiology by Blocking Kisspeptin Signaling NCT01438073 | Massachusetts General Hospital | Phase 1 |
| Completed | Clinical Outcomes in WHO Type I Anovulatory Women Using r-hFSH+r-hLH in a 2:1 Ratio or hMG-HP NCT01623570 | Centro Riproduzione e Andrologia | N/A |
| Terminated | Hypogonadism in Young Men With Type 2 Diabetes NCT01155518 | State University of New York at Buffalo | Phase 2 |
| Terminated | Effect of Varying Testosterone Levels on Insulin Sensitivity in Men With Idiopathic Hypogonadotropic Hypogonad NCT03118479 | Massachusetts General Hospital | Phase 1 |
| Completed | Sequential Therapy for Hypogonadotropic Hypogonadism NCT01403532 | Shanghai Jiao Tong University School of Medicine | Phase 4 |
| Completed | Kisspeptin Administration in the Adult NCT00914823 | Massachusetts General Hospital | Phase 1 |
| Terminated | Luveris® (Lutropin Alfa for Injection) in Women With Hypogonadotropic Hypogonadism (Luteinizing Hormone [LH] L NCT00328926 | EMD Serono | Phase 4 |
| Completed | Clomiphene in Males With Prolactinomas and Persistent Hypogonadism NCT00697814 | Federal University of São Paulo | Phase 2 |
| Unknown | Baselines in Reproductive Disorders NCT00456274 | Massachusetts General Hospital | N/A |
| Completed | Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders NCT00494169 | Massachusetts General Hospital | — |
| Completed | Examination of Idiopathic Hypogonadotropic Hypogonadism (IHH)and Kallmann Syndrome (KS) NCT00392756 | Massachusetts General Hospital | Phase 1 |
| Unknown | Pulsatile GnRH in Anovulatory Infertility NCT00383656 | Massachusetts General Hospital | Phase 2 |