NCT03118479

Effect of Varying Testosterone Levels on Insulin Sensitivity in Men With Idiopathic Hypogonadotropic Hypogonadism (IHH)

Effect of Varying Testosterone Levels on Insulin Sensitivity in Men With Idiopathic Hypogonadotropic Hypogonadism

• Status: Terminated
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 7 (actual)
• Sponsor: Massachusetts General Hospital · Academic / Other
• Sex: Male
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The investigators are doing this research study to look at the relationship between testosterone (the main sex hormone in men) and insulin (the hormone that controls blood sugar levels) in men with Idiopathic Hypogonadotropic Hypogonadism (IHH). The investigators hypothesize that normalizing testosterone levels in men with IHH enhances insulin sensitivity, reduces visceral fat, increases lean body mass, and improves the lipid profile.

Conditions

• Hypogonadotropic Hypogonadism
• Kallmann Syndrome

Interventions

Type	Name	Description
DRUG	Anastrozole Pill	10 mg of Anastrozole to be taken daily for 3 months.
DRUG	Testosterone	Androgel 7.5 g to be applied transdermally daily for 3 months.
DRUG	Placebo Oral Tablet	One tablet to be taken daily for 3 months

Timeline

• Start date: 2010-05-01
• Primary completion: 2010-09-01
• Completion: 2010-09-01
• First posted: 2017-04-18
• Last updated: 2017-04-18

Locations

1 site across 1 country: United States