| Recruiting | Detecting Systemic Carbon Dioxide Levels With a Novel Biosensor NCT06367686 | The Hospital of Vestfold | — |
| Unknown | Treatment of Acute Hypercapnic Respiratory Failure With OptiflowTM or Optiflow+DuetTM Nasal Cannula in COPD-pa NCT06257667 | Aalborg University Hospital | N/A |
| Unknown | Optimal Timing and Failure Prediction of High Flow Nasal Cannula Oxygen Therapy in Emergency Department: Prosp NCT06064409 | Yonsei University | — |
| Recruiting | NIV for Hypercapnic Respiratory Failure: AVAPS vs S/T BIPAP NCT06047405 | Northwell Health | N/A |
| Unknown | Novel ECCO2R Device for Hypercapnic Respiratory Failure NCT05316532 | University of Zurich | — |
| Unknown | Conventional Low Flow Oxygenation Versus High Flow Nasal Cannula in Hypercapnic Respiratory Failure NCT05497986 | Hôpital de Verdun | N/A |
| Completed | Remote Monitoring to Improve Low Adherence in Non-invasive Ventilation NCT04884165 | Guy's and St Thomas' NHS Foundation Trust | N/A |
| Completed | Information-Motivation-Behavioral Skills Model-based Intervention to Domiciliary Non-invasive Ventilation of P NCT05008211 | The University of Hong Kong | N/A |
| Unknown | NHF vs. COT in Hypoxemic Pandemic Viral Illness NCT04750408 | Jens Bräunlich | N/A |
| Completed | Clinical Stabilization of Hypercapnia: NIPPV v HVNI NCT04709562 | Vapotherm, Inc. | N/A |
| Completed | Low-flow Extracorporeal Carbon Dioxide Removal in COVID-19-associated Acute Respiratory Distress Syndrome NCT04351906 | University of Giessen | N/A |
| Completed | Transcutaneous CO2 Measurement - From Hospital to Home NCT06694870 | University of Oslo | — |
| Unknown | High-flow Air Via Nasal Cannula vs Non-invasive Continuous Positive Airway Pressure for Hypercapnic Respirator NCT03944525 | Medical University of Vienna | N/A |
| Unknown | HFNC vs NPPV After Early Extubation for Patients With COPD NCT04156139 | Chinese PLA General Hospital | N/A |
| Terminated | Efficacy of Volume Ventilation in Patients With Acute Respiratory Failure at Risk of Obstructive Apneas or Obe NCT04131660 | University Hospital, Rouen | N/A |
| Completed | Ketogenic Diet for Obesity Hypoventilation Syndrome NCT04108819 | Johns Hopkins University | N/A |
| Completed | Mathematically Arterialised Testing of Hypercapnic Subjects Study NCT04072848 | Papworth Hospital NHS Foundation Trust | — |
| Unknown | High Flow Oxygen and Non Invasive Ventilation for Hypercapnic Respiratory Failure NCT03627598 | University Hospital, Mahdia | N/A |
| Completed | Evaluation of Conventional Non-invasive Mechanical Ventilation (NIV) Versus an Automatic Ventilation Mode. NCT03872167 | Hospital Clinic of Barcelona | N/A |
| Completed | Use of Nasal High Flow Oxygen During Breaks of Non-invasive Ventilation for Patients With Hypercapnic Respirat NCT03406572 | Assistance Publique - Hôpitaux de Paris | N/A |
| Unknown | High Flow Therapy in ICUs Across Ibero America NCT03364946 | Fundación Santa Fe de Bogota | — |
| Unknown | Clinical Evaluation of COPD Butler in Patient Home Management NCT03471091 | The First Affiliated Hospital of Guangzhou Medical University | N/A |
| Terminated | Telemedicine for Improving Outcome in Inner City Patient Population With Hypercapneic Respiratory Failure NCT03353064 | Albert Einstein Healthcare Network | N/A |
| Unknown | The Clinical Application and Popularization of Portable Home Noninvasive Ventilator NCT03238339 | Mingdong Hu | — |
| Unknown | Efficacy of High-intensity NPPV and Low-intensity NPPV in Patients With Chronic Hypercapnic COPD NCT03238014 | The First Affiliated Hospital of Guangzhou Medical University | N/A |
| Unknown | High Flow Nasal Oxygen Versus VNI in Acute Hypercapnic Cardiogenic Pulmonary Edema NCT02874339 | University Hospital, Montpellier | N/A |
| Completed | Comparison of BPAP ST/T and BPAP ST / T Mode With AVAPS for Hypercapnic Respiratory Failure in ED NCT03398239 | Dokuz Eylul University | N/A |
| Completed | Weaning From Noninvasive Ventilation NCT02845076 | Baskent University | N/A |
| Completed | Cardiac and Respiratory Function With Non-invasive Ventilation NCT02699112 | Guy's and St Thomas' NHS Foundation Trust | — |
| Completed | High Flow Nasal Cannula Therapy for Early Management of Acute Hypercapnic Cardiogenic Pulmonary Edema in the E NCT03883555 | University Hospital, Montpellier | — |
| Unknown | Validation of Chinese SRI Questionnaire NCT02240225 | Guangzhou Institute of Respiratory Disease | — |
| Unknown | Non-invasive Positive Pressure (NPPV ) for Severe Stable Chronic Obstructive Pulmonary Disease NCT02499718 | Guangzhou Institute of Respiratory Disease | N/A |
| Completed | Snow Physical Properties and Human Ventilatory Response NCT03082105 | Institute of Mountain Emergency Medicine | N/A |
| Completed | The Effects of Airtrapping on Sleep and Breathing in Non Invasive Ventilation (NIV) in COPD NCT01987661 | Institut für Pneumologie Hagen Ambrock eV | N/A |
| Unknown | NPPV Added Inspiratory Muscle Training in Severe COPD NCT01926275 | Guangzhou Institute of Respiratory Disease | N/A |
| Completed | Use of TpCO2 (Transcutaneous CO2 Measurement) as PaCO2 Predictor During NIV in Case of Acute Hypercapnic Respi NCT01857635 | University of Lausanne Hospitals | — |
| Completed | Helmet Ventilation in Acute Hypercapnic Respiratory Failure NCT01645358 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | Phase 4 |
| Completed | Use of EtCO2 as a PaCO2 Predictor Under Non Invasive Ventilation (NIV) in Cases of Acute Hypercapnic Respirato NCT01489150 | University of Lausanne Hospitals | — |
| Terminated | Home Non-invasive Ventilation for Chronic Obstructive Pulmonary Disease Patients NCT01526642 | University Hospital, Rouen | N/A |
| Unknown | Home Non Invasive Ventilation for COPD Patients NCT03221101 | University Hospital, Rouen | N/A |
| Completed | Withdrawal of Non-invasive Ventilation in Chronic Obstructive Pulmonary Disease (COPD) Patients With Acute Hyp NCT01523470 | United Christian Hospital | Phase 3 |
| Completed | Non-invasive Ventilation Versus Sham Ventilation in Chronic Obstructive Pulmonary Disease (COPD) NCT00429156 | United Christian Hospital | Phase 3 |
| Completed | Clinical Trial Assessing Two Protocols to Withdraw Non-invasive Ventilation in Hypercapnic Respiratory Failure NCT00775710 | Hospital Clinic of Barcelona | Phase 4 |