| Not Yet Recruiting | Optimization Strategies for Blood Transfusion Protocols in the Emergency Treatment of Hemorrhagic Shock NCT07129031 | Xijing Hospital | Phase 3 |
| Recruiting | REVIVE: Reducing Exsanguination Via In-Vivo Expandable Foam NCT02880163 | Arsenal Medical, Inc. | N/A |
| Active Not Recruiting | Biological and Clinical Relevance of Quantra Viscoelastic Hemostatic Assay in Hemorrhagic Cardiac Surgery NCT07105904 | Pitié-Salpêtrière Hospital | — |
| Recruiting | Massive Transfusion in Children-2: A Trial Examining Life Threatening Hemorrhage in Children NCT06070350 | Philip Spinella | Phase 3 |
| Completed | Low Dose of Norepinephrine Within 24-Hour Mortality in Traumatic Patient With Hemorrhagic Shock NCT07053163 | Tanta University | N/A |
| Recruiting | Evaluation of Endothelial Glycocalyx in the Surgical Resuscitation of Major Burn Patients NCT06670248 | Hospital Universitari Vall d'Hebron Research Institute | — |
| Unknown | Norepinephrine in Preperiod of Hypotensive Resuscitation in Hemorrhagic Shock NCT06311903 | Tanta University | N/A |
| Completed | Prospective Validation of the SHOCKMATRIX Hemorrhage Predictive Model NCT06270615 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | Type O Whole Blood and Assessment of Age During Prehospital Resuscitation Trial NCT04684719 | Jason Sperry | Phase 3 |
| Completed | Low-Titer O Positive Whole Blood Versus Component Therapy for Emergent Transfusion in Trauma Patients NCT05081063 | Loma Linda University | Phase 3 |
| Unknown | Detection of Exhaled Methane Levels in Hemorrhagic Shock NCT04987411 | Szeged University | — |
| Terminated | A 48 Subject Study Using Non-invasive Multi-Technology Measurements for Early Detection of Ongoing Hemorrhage NCT04814810 | Dartmouth-Hitchcock Medical Center | — |
| Unknown | Predictors Of Stroke Outcome In Chidren NCT04331457 | Assiut University | — |
| Withdrawn | Philadelphia Immediate Transport in Penetrating Trauma Trial NCT02821364 | Temple University | N/A |
| Unknown | Blood Transfusion by Boston MedFlight Registry NCT04610814 | Massachusetts General Hospital | — |
| Terminated | Pragmatic Prehospital Group O Whole Blood Early Resuscitation Trial NCT03477006 | Jason Sperry | Phase 3 |
| Completed | Transfusion of Red Blood Cells, Tranexamic Acid and Fibrinogen Concentrate for Severe Trauma Hemorrhage NCT04149171 | Cristina Martinez | Phase 3 |
| Completed | Replacing Protein Via Enteral Nutrition in a Stepwise Approach in Critically Ill Patients NCT03480555 | King Abdullah International Medical Research Center | N/A |
| Completed | Shock, Whole Blood, and Assessment of TBI S.W.A.T. (LITES TO 2) NCT03402035 | University of Pittsburgh | — |
| Unknown | Bedside Visual Analysis of Sublingual Microcirculation in Shock Patients NCT03406598 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | HMGB1 Release From Hemorrhagic Shock Patients NCT03535441 | Xingui Dai | — |
| Completed | Sternal Intraosseous Transfusion of Autologous Whole Blood: A Comparison of Flow Rates and Degree of Hemolysis NCT02924792 | Haukeland University Hospital | — |
| Unknown | Use of Nitroglycerine to Improve Signs of Poor Peripheral Perfusion in Patients With Traumatic Hemorrhagic Sho NCT03235921 | Assiut University | Phase 2 |
| Completed | Use of Blood and Plasma in Norwegian Physician-staffed Helicopter Emergency Medical System NCT02784951 | Haukeland University Hospital | — |
| Completed | Effect of Remote Ischemic Conditioning on Trauma Patients With Hemorrhagic Shock NCT02071290 | Unity Health Toronto | N/A |
| Completed | California Prehospital and In Hospital Antifibrinolytic Therapy Via TXA NCT03469947 | Arrowhead Regional Medical Center | Phase 3 |
| Terminated | Control of Major Bleeding After Trauma Study NCT01838863 | Denver Health and Hospital Authority | Phase 2 |
| Withdrawn | Phase 2c Dose Comparison Study of MP4OX in Trauma NCT01973504 | Sangart | Phase 2 |
| Completed | Prehospital Norepinephrine and Early Mortality in Traumatic Shock NCT04497155 | University of Maryland, Baltimore | — |
| Withdrawn | Study Using Plasma for Patients Requiring Emergency Surgery NCT01221389 | Ottawa Hospital Research Institute | Phase 4 |
| Completed | Field Trial of Hypotensive Versus Standard Resuscitation for Hemorrhagic Shock After Trauma NCT01411852 | University of Washington | Phase 2 |
| Completed | Development of an Algorithm for Prediction of Onset of Hemodynamic Instability in Humans NCT00581204 | University of California, Irvine | — |
| Completed | The Cutoff Point for Caval Index and Its Correlation With Central Venous Pressure and Plasma Lactate Level for NCT01741818 | Isfahan University of Medical Sciences | — |
| Completed | Biological Response of Trauma Patients to Standard Trauma Resuscitation Therapy NCT01239680 | University of Missouri, Kansas City | N/A |
| Completed | Vasopressin in Traumatic Hemorrhagic Shock Study NCT00379522 | Volker Wenzel | Phase 2 / Phase 3 |
| Completed | The Trauma- Formula-Driven Versus Lab-Guided Study (TRFL Study) NCT00945542 | Sunnybrook Health Sciences Centre | Phase 1 / Phase 2 |
| Completed | Efficacy, Safety of Solution Containing Hyperosmolar Sodium Lactate Infusion for Resuscitation of Patients Wit NCT01433276 | Innogene Kalbiotech Pte. Ltd | Phase 3 |
| Completed | Resuscitative Endocrinology: Single-dose Clinical Uses for Estrogen-Traumatic Hemorrhagic Shock (RESCUE - Shoc NCT00973102 | University of Texas Southwestern Medical Center | Phase 2 |
| Terminated | Hypertonic Modulation of Inflammation Following Injury NCT00750997 | University of Washington | — |
| Unknown | A Comparison of Two Target Mean Arterial Pressures in the Resuscitation of Hypotensive Trauma Patients NCT00459160 | Baylor College of Medicine | N/A |
| Completed | The Use of rFVIIa in Trauma Patients: A Multi-Center Case Registry NCT00328133 | University of California, San Francisco | — |
| Terminated | The Use of Tissue Oxygen Monitoring in Critically Injured Patients NCT00328341 | University of California, San Francisco | — |
| Unknown | Safety and Efficacy of PolyHeme(R) in Hemorrhagic Shock Following Traumatic Injuries Beginning in the Pre-Hosp NCT00076648 | Northfield Laboratories | Phase 3 |