NCT03535441

HMGB1 Release From Hemorrhagic Shock Patients

Evidence for SIRT1 Mediated HMGB1 Release From Kidney Cells in the Early Stages of Hemorrhagic Shock

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 18 (actual)
• Sponsor: Xingui Dai · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

It is reported that high mobility group box 1 (HMGB1), a non-histone nuclear protein, can serve as an alarmin with damage associated molecular patterns to activate immune responses in the early stages of hemorrhagic shock (HS). However, the origin of HMGB1 and how it is released following HS is poorly understood. In this study, we teased out this mechanism. We try to record the concentration of serum HMGB1 protein following HS in clinical patients.

Detailed description

The study was approved by the First People's Hospital of Chenzhou, Hunan, P.R. China. Consent was obtained from patients in their hospital course. Eighteen patients were enrolled for each group. In addition, Acute Physiological and Chronic Health Evaluation II (APACHE II) score was used to evaluate the severity and morbidity of HS patients Serial blood samples were collected at indicated time points on hospital admission for HS patients (0, 2, 4, 8, 24, and 72 h following HS). Levels of HMGB1 were detected by ELISA according to the kit manufacturer's instructions.

Conditions

• Intensive Care Unit
• Hemorrhagic Shock
• Adult Disease

Timeline

• Start date: 2017-05-17
• Primary completion: 2018-04-11
• Completion: 2018-05-11
• First posted: 2018-05-24
• Last updated: 2018-05-24

Locations

1 site across 1 country: China