NCT04684719

Type O Whole Blood and Assessment of Age During Prehospital Resuscitation Trial

Type O Whole Blood and Assessment of Age During Prehospital Resuscitation (TOWAR) Trial

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 1,020 (actual)
• Sponsor: Jason Sperry · Academic / Other
• Sex: All
• Age: 18 Years – 89 Years
• Healthy volunteers: Not accepted

Summary

Open label, multi-center, pre-hospital randomized trial utilizing 10 level-1 trauma centers designed to determine the efficacy and safety of low titer whole blood resuscitation as compared to standard of care resuscitation in patients at risk of hemorrhagic shock and to appropriately characterize the hemostatic competency of whole blood relative to its age.

Conditions

• Hemorrhagic Shock
• Traumatic Injury

Interventions

Type	Name	Description
BIOLOGICAL	low titer whole blood	low titer whole blood, group O kept to either 21 days or 35 days based upon which preservation process is employed at each respective participating site
BIOLOGICAL	Standard Care	crystalloid infusion or blood component transfusion resuscitation

Timeline

• Start date: 2022-04-19
• Primary completion: 2025-07-28
• Completion: 2025-08-12
• First posted: 2020-12-24
• Last updated: 2026-02-12

Locations

10 sites across 1 country: United States

Regulatory

• FDA-regulated drug study