NCT01239680

Biological Response of Trauma Patients to Standard Trauma Resuscitation Therapy

Biological Response of Trauma Patients to Standard Trauma Resuscitation Therapy.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 5 (actual)
• Sponsor: University of Missouri, Kansas City · Academic / Other
• Sex: All
• Age: 21 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Overall aim of this work is to evaluate new methods of resuscitation that can be applied by front-line responders on the battlefield, in civilian life, or which can be used during initial resuscitation in the first fixed facility to which the injured patient is brought.

Detailed description

Shock is a leading cause of death among American forces in battle, with many trauma victims dying of early hemorrhagic shock or from late septic shock.1 Shock is defined as circulatory collapse, when the arterial blood pressure is too low to maintain an adequate supply of blood to the body's vital organs and tissues. Specifically, hemorrhagic shock results when blood vessels are physically damaged while septic shock results when microbes or microbial products enter the blood stream. Despite advances in medical science, including the development of improved antibiotics, treatments for hemorrhagic and septic shock have changed little in the past 30-40 years. A wounded soldier bleeding on the battlefield, or a trauma victim in the United States, is treated today largely as he or she would have been treated in 1970. The overall aim of this work is to evaluate new methods of resuscitation that can be applied by front-line responders on the battlefield (medical corpsmen, combat medics), in civilian life (Emergency Medical System), or which can be used during initial resuscitation in the first fixed facility to which the injured patient is brought. This might be a Fire Support Specialist (FIST) team in a combat theater or a trauma center in the civilian health care system.

Conditions

• Hemorrhagic Shock

Interventions

Type	Name	Description
DRUG	Glutamine	Intravenous 25 grams once over 6 hours
DRUG	Ringer's Lactate	Intravenous 1 liter once over 6 hours
DRUG	Placebo (for Glutamine)	Given Intravenously in 1 liter Lactated Ringer's

Timeline

• Start date: 2011-01-01
• Primary completion: 2013-11-01
• Completion: 2013-12-01
• First posted: 2010-11-11
• Last updated: 2014-06-17
• Results posted: 2014-06-17

Locations

2 sites across 1 country: United States