| Not Yet Recruiting | Data-Driven Phenotyping in Heart Failure With Preserved Ejection Fraction NCT07429396 | Instituto Politécnico de Leiria | — |
| Not Yet Recruiting | PREACTIVE: Preconditioning Exercise Intervention to Improve Symptoms and Quality of Life in Comorbid Atrial Fi NCT07324772 | Northwestern University | N/A |
| Not Yet Recruiting | Pharmacological Optimization in Prevention in Heart Failure: A Sex-gap? NCT07295522 | IRCCS Policlinico S. Donato | Phase 4 |
| Not Yet Recruiting | CAPTURE-HFpEF: National Study of Identification and Phenotyping of Heart Failure With Preserved Ejection Fract NCT07493590 | Herlev and Gentofte Hospital | — |
| Not Yet Recruiting | AI-based Echocardiography for Detection of Cardiac Amyloidosis NCT07529860 | Germans Trias i Pujol Hospital | N/A |
| Not Yet Recruiting | The Effect of Sacubitril and Valsartan on Heart Function in Chronic Hemodialysis Patients With HFpEF NCT07417215 | University Clinical Hospital Mostar | Phase 4 |
| Recruiting | Treating Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction: Ablation or Medication NCT07272902 | Nova Scotia Health Authority | N/A |
| Not Yet Recruiting | Precision Subtyping and Prognostic Study of Heart Failure Based on Multi-Omics Integration and Clinical Indica NCT07355088 | Xinjiang Medical University | — |
| Recruiting | A Safety, Tolerability, and Biomarker Trial of VS-041 in Participants With Heart Failure With Preserved Ejecti NCT07219511 | Vasa Therapeutics | Phase 1 |
| Completed | Intracranial Pressure and a Potential Vicious Circle of Atrial Fibrillation in HFpEF NCT07521293 | Ankara Ataturk Sanatorium Training and Research Hospital | — |
| Recruiting | Determination of the Prevalence of Unrecognized Heart Failure Among Patients at Risk in Urban Areas Across Ger NCT07185100 | German Heart Institute | — |
| Recruiting | The Use of Advanced Imaging in HFpEF NCT06905405 | Sheffield Teaching Hospitals NHS Foundation Trust | — |
| Recruiting | AI-Based Monitoring System for Chronic Heart Failure With Advanced Wearable and Mini-Invasive Devices NCT06909682 | University of Salerno | — |
| Enrolling By Invitation | Chronic Exogenous Ketosis in HFpEF NCT06937320 | Duke University | Phase 2 |
| Recruiting | ELEVATE-HFpEF Clinical Study NCT06678841 | Medtronic Cardiac Rhythm and Heart Failure | N/A |
| Recruiting | Platelet Derived Growth Factor Receptor ß (PDGFRß) Imaging in Cardiac Fibrosis NCT06956560 | Uppsala University | — |
| Recruiting | IRONICA: IRON Repletion In Heart Failure - A Comparison of Oral and IV Approaches NCT07053475 | Syed Hamza Mufarrih | Phase 4 |
| Recruiting | A Study of IBI362 in Subjects With HFpEF or HFmrEF Combined With Obesity NCT06862908 | Innovent Biologics (Suzhou) Co. Ltd. | Phase 2 |
| Recruiting | Study in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF) NCT06560762 | Secretome Therapeutics | Phase 1 |
| Recruiting | Copenhagen Heart Failure With Preserved Ejection Fraction NCT06685237 | Tor Biering-Sørensen | — |
| Recruiting | The Role of Epicardial Adiposity in Heart Failure With Preserved Ejection Fraction NCT06768437 | University of Leicester | — |
| Enrolling By Invitation | Effects of a Multicomponent Training Program on Cardiac Function, Skeletal Muscle Metabolism, Functional Capac NCT07251361 | Universidad Pública de Navarra | N/A |
| Completed | Emulation of the SUMMIT Heart Failure Trial in Healthcare Claims Data NCT06914154 | Brigham and Women's Hospital | — |
| Enrolling By Invitation | The Effect of Adiposity on Muscle and Microvascular Function in HFpEF NCT06930495 | University of Texas Southwestern Medical Center | — |
| Completed | Mangafodipir - an Intracellular Contrast Agent for Magnetic Resonance Imaging (MRI): Measuring Manganese Uptak NCT06731738 | IC TARGETS AS | Phase 2 |
| Recruiting | Association of Heterogeneous Circulating Biomarkers and Anamnestic Factors of Pregnancy Adverse Course and Out NCT06803849 | National Medical Research Center for Therapy and Preventive Medicine | — |
| Not Yet Recruiting | Effects of an Exercise Program in Women Over 60 yr. With HFpEF and Sarcopenia on Functional Capacity and Quali NCT06655532 | Fundación para la Investigación del Hospital Clínico de Valencia | N/A |
| Not Yet Recruiting | Colchicine in Patients With Heart Failure With Preserved Ejection Fraction and Inflammation NCT06604611 | Dongying Zhang | Phase 4 |
| Recruiting | Feasibility and Effectiveness of Eccentric Exercise in Sarcopenic Older Adults with Heart Failure: a Pilot Stu NCT06826963 | Universita di Verona | N/A |
| Completed | Study for the Treatment of Heart Failure With Preserved Ejection Fraction Associated With High Blood Pressure NCT06036186 | BaroPace Inc. | N/A |
| Completed | Role of Cardiopulmonary Exercise Testing in People With Heart Failure With Preserved Ejection Fraction NCT07394010 | University of Ulster | — |
| Active Not Recruiting | Flow Regulation by Opening the SepTum in Patients With Heart Failure; a Prospective, Randomized, Sham-controll NCT05136820 | Occlutech International AB | N/A |
| Unknown | DevElopMent of Clinical PATHwaYs to the Diagnosis of Heart Failure With Preserved Ejection Fraction NCT05792059 | National Medical Research Center for Therapy and Preventive Medicine | — |
| Recruiting | UK Heart Failure With Preserved Ejection Fraction NCT05441839 | Manchester University NHS Foundation Trust | — |
| Enrolling By Invitation | Cardiac and Metabolic Effects of Semaglutide in Heart Failure With Preserved Ejection Fraction NCT05371496 | Mayo Clinic | Phase 2 |
| Recruiting | Characteristics, Phenotypes, and TRAITS of Heart Failure With Preserved Ejection Fraction (TRAITS-HFpEF) NCT05383287 | Manchester University NHS Foundation Trust | — |
| Recruiting | The Epidemiology and Pathophysiology of Kidney Disease in HFpEF With Obesity NCT07052539 | University of Mississippi Medical Center | — |
| Completed | A Study of Tirzepatide (LY3298176) in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF) NCT04847557 | Eli Lilly and Company | Phase 3 |
| Recruiting | Exercise Capacity According to Coronary Microvascular Dysfunction and Body Composition NCT04822649 | Korea University Anam Hospital | N/A |
| Completed | Sodium-Glucose Cotransporter 2 Inhibitor Use in a National Heart Failure Telemonitoring Program NCT07022379 | Satelia | — |
| Recruiting | Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having HFpEF NCT04592445 | Axon Therapies, Inc. | N/A |
| Completed | Study of Verinurad in Heart Failure With Preserved Ejection Fraction NCT04327024 | AstraZeneca | Phase 2 |
| Completed | A Study to Assess the Effect AZD4831 in Japanese and Chinese Healthy Volunteers NCT04232345 | AstraZeneca | Phase 1 |
| Recruiting | Women's Ischemia Syndrome Evaluation (WISE) Pre-HFpEF NCT03876223 | Cedars-Sinai Medical Center | — |
| Completed | Changes in NT-proBNP, Safety, and Tolerability in HFpEF Patients With a WHF Event (HFpEF Decompensation) Who H NCT03988634 | Novartis Pharmaceuticals | Phase 3 |
| Terminated | An Open-label Extension Study Evaluating Safety and Tolerability of LCZ696 in Subjects Who Completed PARAGON-H NCT03909295 | Novartis Pharmaceuticals | Phase 3 |
| Completed | DETERMINE-preserved - Dapagliflozin Effect on Exercise Capacity Using a 6-minute Walk Test in Patients With He NCT03877224 | AstraZeneca | Phase 3 |
| Completed | A Phase 1 Study to Assess the Pharmacokinetics of AZD9977 Administered Alone and in Combination With Itraconaz NCT03843060 | AstraZeneca | Phase 1 |
| Completed | Ventricular Tachyarrhythmia Detection by Implantable Loop Recording in Patients With Heart Failure and Preserv NCT01989299 | University Medical Center Groningen | — |
| Completed | Evaluation of Left Ventricular Filling Pressures During Exercise NCT01714752 | French Cardiology Society | N/A |
| Completed | Predicting Heart Failure Outcomes With Biomarkers and Imaging NCT07332520 | Xinjiang Medical University | — |
| Enrolling By Invitation | Cardiac MRI-Derived Pressure-Volume Loop Analysis in Heart Failure With Preserved Ejection Fraction NCT07326605 | Chinese Academy of Medical Sciences, Fuwai Hospital | — |