Trials / Recruiting
RecruitingNCT07272902
Treating Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction: Ablation or Medication
A Randomized Ablation-based Atrial Fibrillation Rhythm Control Versus Rate Control Trial in Patients With Heart Failure and Preserved Ejection Fraction (CABANA-RAFT HF): A Pilot Study
- Status
- Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 84 (estimated)
- Sponsor
- Nova Scotia Health Authority · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
This study is testing two different ways of treating atrial fibrillation (AF) in people who also have heart failure with mildly reduced or preserved heart function. Patients will randomly be assigned to either rhythm control using catheter ablation or rate control using medicines. The pilot phase will determine if a larger study can be successfully carried out to see which approach better improves survival, reduces hospitalizations, and enhances quality of life.
Conditions
- Atrial Fibrillation (AF)
- Heart Failure With Mildly Reduced Ejection Fraction
- Heart Failure With Preserved Ejection Fraction (HFPEF)
- Rate Control
- Rhythm Control
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Catheter Ablation for Atrial Fibrillation | Participants randomized to this arm will undergo catheter ablation within 4 weeks of randomization. Pulmonary vein isolation is required; additional ablation strategies may be applied at investigator discretion. Guideline-directed medical therapy for atrial fibrillation and heart failure will also be provided. |
| DRUG | Rate Control Medications (beta-blockers, calcium channel blockers, digoxin) | Participants randomized to this arm will receive pharmacologic therapy to achieve guideline-recommended heart rate control (resting HR \<80 bpm, \<110 bpm with exercise). Therapy may include beta-blockers, non-dihydropyridine calcium channel blockers, or digoxin. If adequate control is not achieved with medication, AV nodal ablation and pacing may be used. Guideline-directed medical therapy for atrial fibrillation and heart failure will also be provided. |
Timeline
- Start date
- 2026-01-01
- Primary completion
- 2027-10-01
- Completion
- 2027-10-01
- First posted
- 2025-12-09
- Last updated
- 2026-02-17
Locations
1 site across 1 country: Canada
Source: ClinicalTrials.gov record NCT07272902. Inclusion in this directory is not an endorsement.