| Not Yet Recruiting | A Phase 1b/2a Study to Evaluate the Safety, Pharmacokinetics, and Objective Response of STAR-001 (LP-184) in C NCT07431216 | Starlight Therapeutics Inc. | Phase 1 / Phase 2 |
| Not Yet Recruiting | Hypofractionated Radiotherapy Plus Temozolamide in Patients Younger Than 70 Years With Glioblastoma NCT07492836 | Hospital do Coracao | N/A |
| Recruiting | Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EG NCT07326566 | Black Diamond Therapeutics, Inc. | Phase 2 |
| Not Yet Recruiting | Impact of Androgen Signaling on the Composition of the Immune Microenvironment in Glioblastomas NCT07472387 | Assistance Publique - Hôpitaux de Paris | N/A |
| Recruiting | A Phase 1/2 Study of the Safety and Tolerability of MT-125 in GBM Patients NCT07185880 | Myosin Therapeutics Inc. | Phase 1 / Phase 2 |
| Not Yet Recruiting | Phase 0/2 PD-Trigger Study of BGB-58067 in Newly Diagnosed Glioblastoma Patients With MTAP-Deleted Tumors NCT07485049 | Nader Sanai | EARLY_Phase 1 |
| Recruiting | Mental Health and Suicidality in Glioblastoma Patients in Germany NCT07409584 | University Hospital, Essen | — |
| Not Yet Recruiting | Study of an AAV Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma NCT07346144 | Trogenix ltd | Phase 1 / Phase 2 |
| Not Yet Recruiting | A Phase I Study of FZ-AD005 in Patients With High-Grade Glioma (HGG) NCT07455045 | Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. | Phase 1 |
| Recruiting | A Phase 0/1 Clinical Trial With an Expansion Phase of GSK5764227, a B7-H3-Targeted Antibody-Drug Conjugate (AD NCT07268053 | Nader Sanai | EARLY_Phase 1 |
| Not Yet Recruiting | Leica Microsystems Sponsored PMCF Study to Collect and Confirm Clinical Data on the Performance of the GLOW400 NCT07366892 | Leica Microsystems (Schweiz) AG | — |
| Recruiting | Prophylactic Regimen With Intrathecal Thiotepa in SVZ-positive or Meningeal-risk Glioblastoma NCT07511725 | Second Affiliated Hospital, School of Medicine, Zhejiang University | Phase 2 |
| Recruiting | Study of Low-Intensity Focused Ultrasound in Combination With Immunotherapy in Newly Diagnosed Unmethylated Gl NCT07343986 | University of Virginia | Phase 1 |
| Not Yet Recruiting | Limited Target Volume Radiotherapy After Glioblastoma Surgery NCT07368283 | Jiangxi Provincial Cancer Hospital | N/A |
| Recruiting | The CCANED-CIPHER Study: Early Cancer Detection and Treatment Response Monitoring Using AI-Based Platelet and NCT06717295 | Javier Toledo | — |
| Enrolling By Invitation | Liquid Biopsy in Glioblastoma Treated With Chemoradiation and an Oxygen Therapeutic NCT07417774 | NuvOx LLC | — |
| Not Yet Recruiting | Prognostic IntraOperative Biomarkers ideNtification in Tumor rElatEd suRgery NCT06617208 | Erasmus Medical Center | N/A |
| Not Yet Recruiting | Safety and Preliminary Efficacy of a Metabolically Armed Chimeric Antigen Receptor T Cell Therapy Targeting EG NCT07244666 | Second Affiliated Hospital, School of Medicine, Zhejiang University | EARLY_Phase 1 |
| Recruiting | Study of TLX101-Tx Plus Standard of Care (SoC) Versus SoC Alone for the Treatment of Patients With Recurrent G NCT07100730 | Telix Pharmaceuticals (Innovations) Pty Limited | Phase 3 |
| Recruiting | A Study to Evaluate the Safety of a Stem Cell-Based Gene and Cell Therapy in Patients With Newly Diagnosed Gli NCT07143812 | CHA University | Phase 1 |
| Recruiting | Local, Targeted Therapy With Alpha Emitter [225Ac]Ac-DOTA-SP (TAT) In Newly Diagnosed Glioma (WHO G3-G4) NCT07488754 | Medical University of Warsaw | N/A |
| Recruiting | UNIty-Based MR-Linac Guided Adaptive RadioThErapy for High GraDe Glioma-4 NCT07459101 | Sunnybrook Health Sciences Centre | N/A |
| Recruiting | FearLess in NeuroOncology NCT06989086 | Virginia Commonwealth University | N/A |
| Enrolling By Invitation | Intrathecal Azacitidine and Nivolumab in Patients With Recurrent High-grade Glioma NCT06896110 | Andrew P. Groves | Phase 1 |
| Active Not Recruiting | A Phase IB 2 Dose Trial of IRS-1 HSV C134 (IND 17296) Administered Intratumorally in Patients With Recurrent M NCT06614855 | James Markert, MD | Phase 1 |
| Recruiting | The Feasibility and Efficacy of Dose Timing (Morning vs Evening) of Temozolomide in the Treatment of Glioblast NCT06850766 | Ottawa Hospital Research Institute | N/A |
| Recruiting | Enhanced Local Intensified Radiation Therapy in Elderly Glioblastoma: A Phase 2 Hybrid Randomized Trial NCT06835803 | Brigham and Women's Hospital | Phase 2 |
| Recruiting | G-CSF After Chemo-radiation in Patients With Glioblastoma NCT06649851 | Massachusetts General Hospital | Phase 2 |
| Recruiting | Stupp Treatment With Intrathecal Injection of Thiotepa for Glioblastoma With Advanced Spread NCT07193654 | Second Affiliated Hospital, School of Medicine, Zhejiang University | Phase 2 |
| Recruiting | Allogeneic γδT Cells in Glioblastoma NCT07144735 | Peking University Third Hospital | N/A |
| Recruiting | DOC1021 Dendritic Cell Immunotherapy for Treatment of Newly Diagnosed Adult Glioblastoma (GBM) NCT06805305 | Diakonos Oncology Corporation | Phase 2 |
| Not Yet Recruiting | CSF Proteomic Characterization of Glioblastomas NCT06845020 | Univeridad Autonoma de Guadalajara | — |
| Completed | Clinical Trial Evaluating Safety of 5-Aminolevulinic Acid (5-ALA) Combined With CV01 Delivery of Ultrasound fo NCT06665724 | Universität Münster | Phase 1 |
| Recruiting | Safety and Efficacy of NRG-103 Injection in the Treatment of Recurrent Glioblastoma Patients NCT06757153 | Zhongnan Hospital | EARLY_Phase 1 |
| Enrolling By Invitation | Sonodynamic-Chemoradiotherapy Integration in Glioblastoma NCT07130149 | Yingjuan Zheng | Phase 2 |
| Recruiting | Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for NCT06607692 | Fundación de investigación HM | Phase 1 / Phase 2 |
| Enrolling By Invitation | Evaluation of [18F]AlF-NOTA-PCP2 PET/CT for PD-L1 Detection in Malignant Tumors NCT06690216 | Man Hu | Phase 1 / Phase 2 |
| Recruiting | Clinical Study of Oncolytic Virus in Glioblastoma NCT07145047 | Mianyang Central Hospital | Phase 1 / Phase 2 |
| Recruiting | Advanced Diffusion MRI to Differentiate Tumor Recurrence From Pseudoprogression in Patients With Glioblastoma NCT05911230 | University Hospital, Basel, Switzerland | N/A |
| Completed | Effect of stRess and exeRcize on the Outcome After Chemo-Radiation NCT05431348 | Maastricht Radiation Oncology | — |
| Completed | A Study to Evaluate the Safety of LAM561 Added to Standard of Care in Newly-diagnosed Glioblastoma Patients NCT03867123 | Laminar Pharmaceuticals | Phase 1 |
| Recruiting | Clinical Significance of Liquid Biopsy in Brain Tumor Patients: a 5-ALA Guided Approach NCT07420543 | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | — |
| Terminated | Prolonged Exposure to Doxorubicin in Patients With Glioblastoma Multiforme and Diffuse Intrinsic Pontine Gliom NCT02758366 | Meyer Children's Hospital IRCCS | Phase 2 |
| Terminated | Ketogenic Diet With Radiation and Chemotherapy for Newly Diagnosed Glioblastoma NCT02046187 | St. Joseph's Hospital and Medical Center, Phoenix | Phase 1 / Phase 2 |