| Recruiting | KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIST in 1st Line Setting NCT07406633 | Kumquat Biosciences Inc. | Phase 2 |
| Recruiting | Lenvatinib After Progression on Imatinib, Sunitinib, and Regorafenib for GIST Patients NCT07096609 | Asan Medical Center | Phase 1 / Phase 2 |
| Recruiting | Phase I Trial to Determine the Dose and Evaluate the PK and Safety of Lutetium Lu 177 Edotreotide Therapy in P NCT06441331 | ITM Solucin GmbH | Phase 1 |
| Recruiting | RCT of EFTR Versus STER for GIST Treatment NCT07411118 | Chinese University of Hong Kong | N/A |
| Recruiting | A Study of Olverembatinib in SDH-deficient GIST. NCT06640361 | Ascentage Pharma Group Inc. | Phase 3 |
| Active Not Recruiting | SARC044: A Phase II Trial of Bezuclastinib in Combination With Sunitinib in Patients With GIST NCT06208748 | Sarcoma Alliance for Research through Collaboration | Phase 2 |
| Active Not Recruiting | A Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With Specific KIT Exon Mutations Who Were Pr NCT05734105 | Deciphera Pharmaceuticals, LLC | Phase 3 |
| Recruiting | A Study of Inlexisertib (DCC-3116) in Combination With Anticancer Therapies in Participants With Advanced Mali NCT05957367 | Deciphera Pharmaceuticals, LLC | Phase 1 / Phase 2 |
| Recruiting | The Australia and New Zealand Multicentre Upper Gastrointestinal Endoscopic Tissue Resection Study NCT05804331 | Western Sydney Local Health District | — |
| Recruiting | TARGETed Therapy Drug MONITOring in DIGestive Oncology NCT05443087 | UNICANCER | N/A |
| Completed | A Drug-drug Interaction Study of Avapritinib and Midazolam NCT04908176 | Blueprint Medicines Corporation | Phase 1 |
| Unknown | Detective Flow Imaging Endoscopic Ultrasonography in Subepithelial Lesions NCT05474794 | Instituto Ecuatoriano de Enfermedades Digestivas | N/A |
| Unknown | Liver Transplantation for Unresectable GIST Liver Metastases NCT04825470 | Hospital Universitario Virgen de la Arrixaca | N/A |
| Unknown | Exploring the Molecular Mechanism Based on KIT Mutation NCT05895942 | Xijing Hospital | — |
| Unknown | French Long Term Registry With Longitudinal Follow up of PDGFRA D842V-GIST Patients NCT04927260 | Centre Leon Berard | — |
| Unknown | Preoperative Radiotherapy in Patients at High Risk of Postoperative Pancreatic Fistula After Pancreatoduodenec NCT05641233 | Erasmus Medical Center | Phase 1 / Phase 2 |
| Completed | Study in Low Risk Gastrointestinal Stromal Tumor (GISTs) NCT04599660 | Italian Sarcoma Group | — |
| Completed | Clinical Evaluation of Genetron D842V PCR Kit in GIST Patients NCT05400018 | Genetron Health | — |
| Unknown | NIR Fluorescence Imaging With ICG for the Intraoperative Identification of Gastrointestinal Stromal Cell Tumou NCT04761172 | Leiden University Medical Center | Phase 2 / Phase 3 |
| Withdrawn | Long-term Surival of GIST Patients ≥ 10 Years on Imatinib NCT04097093 | European Organisation for Research and Treatment of Cancer - EORTC | — |
| Unknown | Selinexor as Single Agent and With Imatinib in Metastatic and/or Unresectable Gastrointestinal Stromal Tumors NCT04138381 | Grupo Espanol de Investigacion en Sarcomas | Phase 1 / Phase 2 |
| Unknown | The PIONEER Initiative: Precision Insights On N-of-1 Ex Vivo Effectiveness Research Based on Individual Tumor NCT03896958 | SpeciCare | — |
| Active Not Recruiting | Temozolomide (TMZ) in Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor ( NCT03556384 | Adam Burgoyne, MD, PhD | Phase 2 |
| Unknown | A Phase I/II Study of Regorafenib Plus Avelumab in Solid Tumors NCT03475953 | Institut Bergonié | Phase 1 / Phase 2 |
| Completed | (VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIS NCT03465722 | Blueprint Medicines Corporation | Phase 3 |
| Unknown | To Compare the Efficacy of Surgery Followed by Sunitinib With Surgery Followed by Imatinib in GIST Patients Wi NCT03424876 | Peking University | — |
| Unknown | Long Outcome of Endoscopic Submucosal Dissection for Small Gastrointestinal Stromal Tumors (<2cm) NCT03082079 | Nanfang Hospital, Southern Medical University | N/A |
| Recruiting | Familial Investigations of Childhood Cancer Predisposition NCT03050268 | St. Jude Children's Research Hospital | — |
| Completed | Distress, Medication Adherence and Care Needs in Patients With CML and GIST Receiving Oral Targeted Therapy NCT03880617 | National Taiwan University Hospital | — |
| Completed | Phase II Trial of Vandetanib in Children and Adults With Wild-Type Gastrointestinal Stromal Tumors NCT02015065 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Clinical Registry of nCLE in Masses and Cystic Tumors of the Pancreas, Lymph Nodes, Submucosal Lesions of the NCT01770405 | Mauna Kea Technologies | — |
| Unknown | A Clinical Trial With a New Needle Device Comparing Two Needles for EUS_FNA of Solid Lesions. NCT02246322 | Istituto Clinico Humanitas | N/A |
| Completed | A Phase 2 Trial of Ponatinib in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumo NCT01874665 | Ariad Pharmaceuticals | Phase 2 |
| Completed | Evaluation of a New EUS-guided Needle (ProCore) Comparing to EUS-TCB Needle (Quick-Core) NCT01768325 | Indiana University | N/A |
| Completed | Non-Interventional Retrospective Correlation Of Tumor Mutational Status To Clinical Benefit Of GIST Patients T NCT01459757 | Pfizer | — |
| Completed | Vaccine Therapy in Treating Patients With Metastatic Solid Tumors NCT01376505 | Robert Wesolowski | Phase 1 |
| Completed | Efficacy of Pazopanib in Gastrointestinal Stromal Tumors (GIST) NCT01323400 | Centre Leon Berard | Phase 2 |
| Completed | Evaluation of Cognitive Function of Patients With Sunitinib or Sorafenib NCT01246843 | Radboud University Medical Center | — |
| Terminated | Trial of Tasigna (Nilotinib) 400 mg Twice Daily Alone or With Gleevec (Imatinib Mesylate) 400 mg Daily for Pat NCT01089595 | Fox Chase Cancer Center | Phase 2 |
| Completed | Study of the Immunoresponse in Patients Treated With a Tyrosine Kinase Inhibitor NCT00979381 | Radboud University Medical Center | — |
| Completed | Study on the Influence of Sunitinib and Sorafenib on Fatigue, QoL, Depression in Patients With Metastatic RCC NCT00979329 | Radboud University Medical Center | — |
| Unknown | 11C-Acetate PET/CT Non-FDG-Avid Tumors NCT00687778 | Tel-Aviv Sourasky Medical Center | — |
| Completed | An Open-Label, 18FDG-PET Pharmacodynamic Assessment of the Effect of BIIB021 in Subjects With Gastrointestinal NCT00618319 | Biogen | Phase 2 |
| Completed | Perifosine + Sunitinib Malate for Patients With Advanced Cancers NCT00399152 | AEterna Zentaris | Phase 1 |
| Approved For Marketing | Early Access Program (EAP) for Avapritinib in Patients With Locally Advanced Unresectable or Metastatic GIST NCT03862885 | Blueprint Medicines Corporation | — |